Thrombospondin 1

An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.

Also Known As:

Networked: 561 relevant articles (13 outcomes, 90 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lawler, Jack: 26 articles (02/2015 - 01/2002)
2.	Roberts, David D: 8 articles (07/2015 - 12/2007)
3.	Masli, Sharmila: 7 articles (09/2015 - 04/2004)
4.	Gutierrez, Linda S: 7 articles (05/2015 - 02/2003)
5.	Frangogiannis, Nikolaos G: 6 articles (10/2014 - 06/2005)
6.	Tuszynski, George P: 6 articles (01/2010 - 08/2002)
7.	Taraboletti, Giulia: 5 articles (10/2015 - 12/2003)
8.	Martiny, Laurent: 5 articles (01/2015 - 03/2005)
9.	Ryeom, Sandra: 5 articles (04/2014 - 10/2006)
10.	Rak, Janusz: 5 articles (04/2013 - 08/2003)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2001 - "TSP-1 was suggestive for improved survival in patients with advanced disease; high TSP-1 expression was associated with a median survival of 2.4 years compared to 1.5 years for patients with tumors having a lower degree of TSP-1 expression (P = 0.06). " 01/01/2013 - "The assessment of TSP-1 and ITG levels might contribute to earlier metastatic potential of BRAF(V600E)-positive aggressive thyroid cancers, and allow improved patient selection for clinical trials." 07/01/2011 - "Although the contribution of TGF-β signaling to DF or DFSP is still unknown, the expression patterns of TSP-1 in DF cells and DFSP cells may be helpful in differential diagnosis of these tumors." 03/01/2009 - "In univariate analyses CD31 MVD, but not tumor TSP-1, was associated with improved PFS (HR=0.37; 95% CI=0.18-0.76; p=0.007) and OS (HR=0.37; 95% CI=0.17-0.79; p=0.010). " 01/01/2013 - "Transcriptional regulation of TSP-1 in osteogenesis and cancer is poorly understood; this prompted us to study its regulation by the two key regulators of the aforementioned processes: Runx2 and Runx3. "
2.	Fibrosis (Cirrhosis) 12/01/2010 - "TSP-1 in lung fibrosis." 08/01/2009 - "Plasma TSP-1 may be used for an important biomarker of renal interstitial fibrosis." 08/01/2009 - "Plasma TSP-1 expression is positively correlated with renal interstitial fibrosis in protein-overload rats. " 08/01/2009 - "To observe the expression of plasma thrombospondin-1(TSP-1) at different time in protein-overload rats and to analyze the relationship between plasma TSP-1 expression and renal interstitial fibrosis. " 04/14/2008 - "Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (P < 0.05). "
3.	Carcinoma (Carcinomatosis) 02/01/2012 - "In this study we investigated tissue sections from 124 breast carcinomas for the immuno-histochemical expression of TSP-1 protein and its relationship to several clinicopathological parameters. " 01/01/2012 - "Alteration of HGF and TSP-1 expression in ovarian carcinoma associated with clinical features." 12/15/2011 - "Here, we reevaluated the role of the endogenous antiangiogenic thrombospondin 1 (TSP1) in prostate carcinomas in which angiogenesis is an active process. " 01/01/2009 - "Thrombospondin 1 expression and angiogenesis in breast carcinoma and their relation with platelet activity." 09/20/2005 - "TSP-1 was found to be expressed in the stroma of human breast carcinomas where, although its level correlated with decreased vascularization, it was unexpectedly associated with a reduction of relapse-free survival. "
4.	Neoplasm Metastasis (Metastasis) 05/01/2013 - "We also developed a 5-amino acid peptide from prosaposin as a pharmacologic inducer of Tsp-1 in Gr1(+) bone marrow cells, which dramatically suppressed metastasis. " 01/22/2013 - "However, the relationship between TSP-1 levels and lymph node metastasis remained elusive (P = 0.189). " 01/01/2013 - "Our findings also suggest that TSP-1 promotes lymph node metastasis and TSP-1 potentially could be a predictive marker for metastasis." 02/01/2010 - "Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1." 01/01/2010 - "TSP-1 positive expression was significantly lower in patients with cervical lymph node metastasis or relapse at 5 years (p<0.05). "
5.	Thyroid Neoplasms (Thyroid Cancer) 06/08/2010 - "Knockdown of B-Raf(V600E) resulted in TSP-1 down-regulation and a reduction of adhesion and migration/invasion of human thyroid cancer cells. " 01/01/2008 - "Our results show that TSP-1 can have opposite effects on cell invasion depending upon the type of differentiated thyroid carcinoma studied." 03/01/2006 - "We have identified ID3 and TSP-1 as two new downstream targets of PTTG in thyroid cancer. " 03/10/2005 - "Therefore, analyzing differential regulation of TSP-1 by growth factors such as EGF can be helpful in understanding thyroid cancer development." 03/10/2005 - "In the present study, we found that epidermal growth factor (EGF) up-regulated TSP-1 expression in FTC-133 (primary tumor) but not in FTC-238 (lung metastasis) thyroid cancer cells. "

Related Drugs and Biologics

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2.	Transforming Growth Factor beta1 (TGF beta 1)
3.	Endostatins
4.	Epidermal Growth Factor (EGF)
5.	Collagen
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Alkalies
8.	Transforming Growth Factor beta (TGF-beta)
9.	Messenger RNA (mRNA)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Lasers (Laser)
3.	Injections
4.	Refractive Surgical Procedures
5.	Transplants (Transplant)