Thrombospondins

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

Also Known As:

Networked: 651 relevant articles (13 outcomes, 62 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hill, Adrian V S: 12 articles (11/2014 - 04/2003)
2.	Gilbert, Sarah C: 9 articles (11/2014 - 06/2003)
3.	Bejon, Philip: 8 articles (05/2015 - 02/2005)
4.	Edwards, Dylan R: 7 articles (02/2015 - 04/2004)
5.	Nagase, Hideaki: 6 articles (11/2015 - 12/2004)
6.	López-Otín, Carlos: 6 articles (05/2015 - 01/2002)
7.	Wada, Hideo: 6 articles (11/2014 - 10/2004)
8.	Frangogiannis, Nikolaos G: 6 articles (02/2014 - 06/2005)
9.	Zheng, X Long: 6 articles (02/2014 - 06/2004)
10.	Kazura, James W: 6 articles (05/2011 - 09/2004)

Related Diseases

1.	Malaria 11/20/2014 - "In an attempt to improve the efficacy of the candidate malaria vaccine RTS,S/AS02, two studies were conducted in 1999 in healthy volunteers of RTS,S/AS02 in combination with recombinant Plasmodium falciparum thrombospondin-related anonymous protein (TRAP). " 09/01/1999 - "We have investigated whether naturally induced immunity to Plasmodium falciparum thrombospondin related adhesive protein contributes to protection against malaria in humans. " 05/15/2012 - "A vaccine containing tandem repeats, region III, and thrombospondin type-I repeat (TSR) of CS is efficacious in phase III trials but gives only a 35% reduction in severe malaria in the first year postimmunization. " 03/01/2012 - "From 2007 to 2010, we undertook a phase I dose and route finding study of a new malaria vaccine, a replication-incompetent chimpanzee adenovirus 63 (ChAd63) encoding the preerythrocytic insert multiple epitope thrombospondin-related adhesion protein (ME-TRAP; n = 54 vaccinees) administered alone (n = 28) or with a modified vaccinia virus Ankara (MVA) ME-TRAP booster immunization 8 weeks later (n = 26). " 01/01/2008 - "Toward further understanding of how host-parasite and parasite-parasite relationships may impact virulence, this study characterizes within-host diversity of malaria parasite populations based on genetic analysis of the trap (thrombospondin-related anonymous protein) gene in isolates originating from Hawaii, Maui and Kauai Islands. "
2.	Neoplasms (Cancer) 07/15/2008 - "In our study, a disintegrin-like and metalloprotease with thrombospondin type 1 motif 9 (ADAMTS9), a gene mapping to 3p14.2, was identified to be critically associated with tumor suppression in NPC. " 02/15/1998 - "In a recent study, thrombospondin was discovered not only to accelerate platelet aggregation and to promote construction of the extracellular matrix but also to be involved in the progression of malignant tumors. " 05/01/1989 - "Previous studies have shown that thrombospondin (TSP) is an adhesion factor for some human tumor cells. " 05/14/2015 - "Analysis of human blood samples and tumor tissue revealed that a promoted VWF release combined with a local inhibition of proteolytic activity and protein expression of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type I repeats 13) accounts for this procoagulatory milieu. " 01/01/2015 - "We report moderate associations of variant rs4954368 in THSD7B (thrombospondin, type I, domain containing 7B) with tumor size in pooled analysis of AA and EA samples (P = 0.004), and at TNRC6B (trinucleotide repeat containing 6B) variants rs138039 and rs139909 in EA (P = 0.001 and 0.008, respectively). "
3.	Thrombotic Thrombocytopenic Purpura 01/01/2013 - "We also obtained results which showed severely deficient plasma a disintegrin-like and metalloprotease with thrombospondin motifs (ADAMTS) 13 activity and positive ADAMTS13 inhibitor, confirming a diagnosis of thrombotic thrombocytopenic purpura. " 10/01/2012 - "Both children had severe deficiency of ADAMTS13 (A Disintegrin And Metalloprotease with Thrombospondin like domain activity) confirming the diagnosis of congenital thrombotic thrombocytopenic purpura. " 10/01/2011 - "Although a blood marker of hepatic stellate cells is not known, those cells importantly contribute to the regulation of plasma a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) activity, a defect of which causes thrombotic thrombocytopenic purpura. " 06/01/2008 - "Recent advances showed that ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13) is closely related to thrombotic thrombocytopenic purpura, a multiorgan disorder. " 10/01/2015 - "Thrombotic thrombocytopenic purpura (TTP) is a severe disorder affecting the microcirculation of multiple organs due to a systemic endothelial cell injury secondary to a deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity. "
4.	Infection 08/01/2014 - "hominis at the MIC1 locus, which encodes a microneme localized thrombospondin-like domain containing protein previously demonstrated to be critical for host cell infection by C. " 10/01/2008 - "Targeted gene deletion of UOS3, encoding a putative transmembrane protein with a thrombospondin repeat that localizes to the sporozoite secretory organelles, rendered oocyst sporozoites unable to infect the mosquito salivary glands but maintained the parasites' liver infection competence. " 03/15/2013 - "TRAP (thrombospondin-related anonymous protein), localized in the micronemes and on the surface of sporozoites of the notorious malaria parasite Plasmodium, is a key molecule upon infection of mammalian host hepatocytes and invasion of mosquito salivary glands. " 01/01/2012 - "Infective trypomastigotes up-regulate the expression of laminin γ-1 (LAMC1) and thrombospondin (THBS1) to facilitate the recruitment of trypomastigotes to enhance cellular infection. " 04/01/2003 - "Ex vivo interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of Plasmodium falciparum infection."
5.	Membranous Glomerulonephritis (Membranous Nephropathy) 03/12/2015 - "Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy." 03/12/2015 - "Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy." 02/01/2015 - "Glomerular disease: thrombospondin type-1 domain-containing 7A-a new player in membranous nephropathy." 01/01/2015 - "Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy." 12/11/2014 - "Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy."

Related Drugs and Biologics

1.	Peptides
2.	rituximab (Mabthera)
3.	thymidine 5'-triphosphate (TTP)
4.	Matrix Metalloproteinase 2 (Gelatinase A)
5.	Proteins (Proteins, Gene)
6.	Collagen
7.	Endostatins
8.	Antigens
9.	Antineutrophil Cytoplasmic Antibodies (ANCA)
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Plasma Exchange
2.	Angioplasty (Angioplasty, Transluminal)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Traction
5.	Splenectomy