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Technetium Tc 99m Exametazime (Ceretec)

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A gamma-emitting radionuclide imaging agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and myocardial imaging. It has also been used to label leukocytes in the investigation of inflammatory bowel diseases.

Also Known As:

Ceretec; 99m-Tc-HMPAO; 99mTc-HMPAO; Tc-99m-Exametazime; Tc-99m-Hexamethylpropyleneamine Oxime; Technetium Tc 99m Hexamethylpropylene-amine Oxime; Oxime, Tc-99m-Hexamethylpropyleneamine; Tc 99m Exametazime; Tc 99m Hexamethylpropyleneamine Oxime; Technetium Tc 99m Hexamethylpropylene amine Oxime; Tc-99m HMPAO; Technetium Tc 99m Hexamethylpropyleneamine Oxime

Networked: 563 relevant articles (7 outcomes, 95 trials/studies)

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Drug Context: Research Results

Experts

1.	Kao, A: 6 articles (05/2004 - 01/2002)
2.	Sasaki, Masayuki: 4 articles (07/2009 - 05/2002)
3.	Kao, Chia-Hung: 3 articles (09/2012 - 03/2003)
4.	Varoglu, Erhan: 3 articles (04/2007 - 05/2003)
5.	Yildirim, Mustafa: 3 articles (04/2007 - 05/2003)
6.	Uslu, Hatice: 3 articles (04/2007 - 05/2003)
7.	Koga, Hirofumi: 3 articles (06/2004 - 05/2002)
8.	Nakagawa, Makoto: 3 articles (06/2004 - 05/2002)
9.	Hsu, W H: 3 articles (05/2004 - 07/2003)
10.	Bourguet, P: 3 articles (12/2002 - 01/2000)

Related Diseases

1.	Brain Death (Brain Dead) 07/15/2000 - "In this setting, transcranial Doppler is superior to 99mTc-HMPAO in reducing the waiting time for a firm diagnosis of brain death." 01/01/2000 - "We determined how well the clinical examination criteria held up in the diagnosis of brain death against the new gold standard of Tc-99m HMPAO scintigraphy: Clinical examination criteria correctly predicted brain death only 83% of the time compared with HMPAO scintigraphy. " 10/01/1994 - "These differences and the present study suggest that Tc-99m HMPAO is a superior agent for cerebral perfusion studies to determine brain death." 05/01/1993 - "The results of the Tc-99m HMPAO brain death studies correlated well with the patients' clinical conditions. " 12/01/2004 - "Eight patients who fulfilled the clinical criteria of brain death underwent Tc-99m HMPAO SPECT and electroencephalogram (EEG) monitoring. "
2.	Melanoma (Melanoma, Malignant) 06/01/1995 - "The purpose of this study was to evaluate Tc-99m HMPAO as an effective agent for localizing malignant melanomas on the radioisotope imaging. " 12/01/1999 - "Scintigraphic studies carried out in melanoma patients have demonstrated that the 99mTc-HMPAO complex makes it possible to locate the lesion. " 08/01/1999 - "Ocular malignant melanoma detected with Tc-99m MIBI and Tc-99m HMPAO." 06/01/1995 - "Tc-99m HMPAO appears to be a useful agent for the localization of both the primary focus and unexpected metastatic lesion in patients with malignant melanoma." 06/01/1995 - "Detection of malignant melanoma by Tc-99m HMPAO."
3.	Epilepsy (Aura) 08/01/1991 - "Thirteen mentally retarded pediatric patients aged 4 to 13 years with therapy-resistant epilepsy underwent Tc-99m HMPAO brain perfusion SPECT studies. " 06/01/2014 - "To differentiate EEG abnormalities due to a hemodynamic deficit induced by habitual neck compression from an epileptic seizure, Tc-99m HMPAO SPECT was performed immediately after right carotid artery compression. " 06/01/2014 - "Here, we present a case of electroencephalogram (EEG) abnormalities induced by habitual neck compression differentiated from epileptic seizures by Tc-99m HMPAO SPECT. " 06/01/2014 - "A Case of Habitual Neck Compression Induced Electroencephalogram Abnormalities: Differentiating from Epileptic Seizures Using a Tc-99m HMPAO SPECT." 11/01/1995 - "Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children."
4.	Seizures (Seizure) 08/01/2001 - "Tc-99m HMPAO brain SPECT is useful for evaluating focal convulsions associated with H. " 06/01/2001 - "We describe a case of transient seizure activity demonstrated by Tc-99m HMPAO SPECT and DWI. " 06/01/2001 - "Transient seizure activity demonstrated by Tc-99m HMPAO SPECT and diffusion-weighted MR imaging." 04/01/1999 - "Comparison between semiquantitative interictal Tc-99m HMPAO SPECT and clinical parameters in children with partial seizures." 03/01/1999 - "SPECT scans were performed using Tc-99m-hexamethylpropyleneamine oxime (HMPAO) injected within 30 seconds of electrographic seizure onset and were graded on a scale from 1 to 5 (1 weakly perfused, 5 strongly perfused). "
5.	Appendicitis 02/01/2002 - "Therefore, the clinical efficacy of Tc-99m HMPAO labeled leukocyte (TC-WBC) scan for the diagnosis of acute appendicitis in patients presenting with atypical clinical findings is assessed. " 03/01/2003 - "The aim of this study is to assess and compare the value of the Tc-99m HMPAO (technetium-99m hexamethylpropyleneamineoxide) labeled white blood cell abdomen scan and abdominal sonography in the diagnosis of acute appendicitis in children with an atypical clinical presentation. " 03/01/2003 - "The Tc-99m HMPAO white blood cell abdomen scan provides a more sensitive and accurate method for the diagnosis of appendicitis in children with atypical clinical presentation when compared with abdominal sonography." 03/01/2003 - "The overall sensitivity, specificity, and accuracy of Tc-99m HMPAO white blood cell scan to diagnose acute appendicitis in children with atypical findings is 96.7%, 80.0%, and 90.0%, respectively. " 01/01/2003 - "The Tc-99m HMPAO white blood cell scan provides a more sensitive and accurate method for the diagnosis of appendicitis in female patients with equivocal clinical presentation when compared with abdominal sonography."

Related Drugs and Biologics

1.	Benzodiazepines
2.	Barbiturates
3.	Acetazolamide (Diamox)
4.	technetium Tc 99m bicisate (Neurolite)
5.	Inosine Monophosphate (IMP)
6.	gallium citrate
7.	iomazenil
8.	Levodopa (L Dopa)
9.	Tropolone
10.	Niacinamide (Nicotinamide)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Endarterectomy (Thromboendarterectomy)
3.	Gamma Cameras (Gamma Camera)
4.	Transplants (Transplant)
5.	Drug Therapy (Chemotherapy)