High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
Also Known As:
Kininogen, High Molecular Weight; HMWK; Kininogen, High-Molecular-Weight; Fitzgerald Factor; High Molecular Weight Kininogen; High Molecular Weight Kininogens; High-Molecular-Weight Kininogens; Kininogens, High Molecular Weight; Kininogens, High-Molecular-Weight
Networked: 144 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Colman, Robert W: 14 articles (12/2010 - 07/2002)
2. Pixley, Robin A: 8 articles (12/2010 - 07/2002)
3. Isordia-Salas, Irma: 8 articles (11/2005 - 07/2002)
4. Sainz, Irma M: 5 articles (09/2007 - 09/2004)
5. Agelan, Alexis: 3 articles (12/2010 - 09/2004)
6. Liu, Yuchuan: 3 articles (12/2010 - 09/2007)
7. Martínez-Murillo, Carlos: 3 articles (11/2005 - 09/2004)
8. Sartor, R Balfour: 3 articles (08/2005 - 07/2002)
9. Adam, Albert: 3 articles (08/2005 - 07/2002)
10. Renné, Thomas: 2 articles (09/2015 - 09/2008)

Related Diseases

1. Inflammation
2. Thrombosis (Thrombus)
3. Edema
11/01/1984 - "Replacement therapy with C 1-inhibitor preparation for an edema attack revealed that clinical improvement paralleled the increase in blood levels of high molecular weight kininogen. "
03/07/2000 - "LlTI inhibits kinin release from high molecular weight kininogen by human plasma kallikrein in vitro and, administered intravenously, causes a decrease in paw edema induced by carrageenin or heat in male Wistar rats. "
10/01/1989 - "Therefore, we conclude that bradykinin generated by plasma kallikrein-induced cleavage of HMWK is not involved in the pathogenesis of edema due to acute exposure to high altitude."
05/01/2008 - "Several of the key processes that underlie the development of diabetic retinopathy, such as increased vascular permeability, edema, neovascularization, and inflammatory changes, have been associated with the KKS, and recent work has shown that components of the KKS, including plasma kallikrein, factor XIIa, and high-molecular-weight kininogen, are present in the vitreous of people with diabetic retinopathy. "
09/01/2008 - "This review focuses on articles, which report phenotypization of animals deficient in the contact system proteins factor XII, factor XI and high-molecular-weight kininogen, as well as novel links between factor XII and edema formation, discovery of new in-vivo activators of factor XII, and functions of the factor XII downstream protease factor XI. Recent studies improved understanding of the factor XII-driven contact system in hemostasis, thrombosis, and inflammation. "
4. Rheumatoid Arthritis
5. Hereditary Angioedemas

Related Drugs and Biologics

1. Factor XII (Hageman Factor)
2. Factor XI (Plasma Thromboplastin Antecedent)
3. Proteins (Proteins, Gene)
4. High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)
5. Prekallikrein
6. Plasma Kallikrein
7. Keratins (Keratin)
8. Low-Molecular-Weight Kininogen (Kininogen, Low Molecular Weight)
9. Kinins
10. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)

Related Therapies and Procedures

1. Renal Dialysis (Hemodialysis)
2. Catheters
3. Cautery
4. Aftercare (After-Treatment)