High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)

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Networked: 210 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Colman, Robert W: 16 articles (01/2019 - 07/2002)
2.	Pixley, Robin A: 8 articles (12/2010 - 07/2002)
3.	Isordia-Salas, Irma: 8 articles (11/2005 - 07/2002)
4.	Renné, Thomas: 5 articles (02/2022 - 09/2008)
5.	Sainz, Irma M: 5 articles (09/2007 - 09/2004)
6.	Strickland, Sidney: 4 articles (01/2021 - 01/2017)
7.	Wu, Yi: 4 articles (01/2019 - 09/2007)
8.	Schmaier, Alvin H: 4 articles (01/2018 - 06/2003)
9.	Gu, Ja-Yoon: 3 articles (07/2022 - 05/2017)
10.	Kim, Hyun Kyung: 3 articles (07/2022 - 05/2017)

Related Diseases

1.	Inflammation (Inflammations) 04/01/2019 - "Prekallicrein can be activated at the endothelial surface in the presence of high molecular weight kininogen, whose cleavage generates bradykinins and contributes to vessel tonicity and inflammation. " 11/01/2005 - "[High molecular weight kininogen in inflammation and angiogenesis: a review of its properties and therapeutic applications]." 01/01/2005 - "The role of plasma high molecular weight kininogen in experimental intestinal and systemic inflammation." 09/01/2004 - "The role of plasma high molecular weight kininogen in experimental intestinal and systemic inflammation." 10/15/2003 - "The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation."
2.	Thrombosis (Thrombus) 04/01/2016 - "Mice lacking high molecular weight kininogen, a cofactor for PK activation and activity, were also partially resistant to thrombosis at 5% FeCl3. " 06/01/2003 - "A 6-year-old male with vertebral-basilar artery thrombosis was recognized to have high-molecular-weight kininogen (HK) deficiency. " 09/01/1999 - "Brown-Norway Katholiek strain rats with an absence of low- and high-molecular-weight kininogen due to a single point mutation, A163T, were compared in the thrombosis model to the wild-type animals, which were otherwise genetically identical. " 03/27/2014 - "To determine the extent to which catheter thrombosis is triggered by the contact or extrinsic pathway of coagulation, we used antisense oligonucleotides (ASOs) to selectively knock down factor (f)XII, fXI, or high-molecular-weight kininogen (HK), key components of the contact pathway, or fVII, which is essential for the extrinsic pathway. " 07/01/2004 - "gC1q-R/p33 (gC1q-R) is a multifunctional and multicompartmental cellular protein, which is postulated to play a role in inflammation and thrombosis by interacting with C1q and high molecular weight kininogen (HK). "
3.	Edema (Dropsy) 11/01/1984 - "Replacement therapy with C 1-inhibitor preparation for an edema attack revealed that clinical improvement paralleled the increase in blood levels of high molecular weight kininogen. " 01/01/2018 - "Cleavage of high-molecular-weight kininogen liberates bradykinin, the major biologic peptide that promotes the edema. " 10/01/1989 - "Therefore, we conclude that bradykinin generated by plasma kallikrein-induced cleavage of HMWK is not involved in the pathogenesis of edema due to acute exposure to high altitude." 05/01/2008 - "Several of the key processes that underlie the development of diabetic retinopathy, such as increased vascular permeability, edema, neovascularization, and inflammatory changes, have been associated with the KKS, and recent work has shown that components of the KKS, including plasma kallikrein, factor XIIa, and high-molecular-weight kininogen, are present in the vitreous of people with diabetic retinopathy. " 03/07/2000 - "LlTI inhibits kinin release from high molecular weight kininogen by human plasma kallikrein in vitro and, administered intravenously, causes a decrease in paw edema induced by carrageenin or heat in male Wistar rats. "
4.	Rheumatoid Arthritis 01/01/1979 - "The significant reduction of high molecular weight-kininogen in synovial fluid of patients with active rheumatoid arthritis." 03/01/2018 - "Rheumatoid arthritis patients and controls carried the wild type allele of 587C>T; therefore, produced the high molecular weight kininogen. " 01/01/2006 - "High molecular weight kininogen (HK) is a plasma protein that is cleaved by plasma kallikrein in the clinical settings of sepsis and chronic inflammatory diseases such as rheumatoid arthritis and Crohn's disease. "
5.	Margins of Excision 08/01/2011 - "We hypothesized that staining for CK5/6 and HMWK (34bE12) may be helpful in evaluating the cauterized surgical margins, given the 2 antibodies follow the same pattern as described in the preserved foci of the 2 entities. " 08/01/2011 - "Our results strongly suggest that antibodies for CK5/6 and HMWK (34bE12) may be useful in determining the presence of DCIS at surgical margins even in the event of severe cautery artifact."

Related Drugs and Biologics

1.	Factor XII (Hageman Factor)
2.	Proteins (Proteins, Gene)
3.	Factor XI (Plasma Thromboplastin Antecedent)
4.	Peptide Hydrolases (Proteases)
5.	Antibodies
6.	High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)
7.	Prekallikrein
8.	Plasma Kallikrein
9.	Keratins (Keratin)
10.	Kinins

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)
3.	Catheters
4.	Critical Care (Surgical Intensive Care)
5.	Cautery