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Cortical Blindness (Anton Syndrome)

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Total loss of vision in all or part of the visual field due to bilateral OCCIPITAL LOBE (i.e., VISUAL CORTEX) damage or dysfunction. Anton syndrome is characterized by the psychic denial of true, organic cortical blindness. (Adams et al., Principles of Neurology, 6th ed, p460)

Also Known As:

Anton Syndrome; Syndrome, Anton; Blindness, Cortical; Anton's Syndrome; Anton-Babinski Syndrome; Blindness, Cortical, Post-Ictal; Blindness, Cortical, Transient; Reversible Cortical Blindness; Transient Anton's Syndrome; Anton Babinski Syndrome; Anton's Syndrome, Transient; Antons Syndrome; Blindness, Reversible Cortical; Blindnesses, Reversible Cortical; Cortical Blindness, Reversible; Cortical Blindnesses, Reversible; Reversible Cortical Blindnesses; Syndrome, Anton's; Syndrome, Anton-Babinski; Syndrome, Transient Anton's; Transient Anton Syndrome; Transient Antons Syndrome; Psychic Denial of Blindness

Networked: 169 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure)
2.	Pneumonia (Pneumonitis)
3.	Seizures (Seizure)
4.	Coma (Comas)
5.	Neurofibromatoses (Neurofibromatosis)

Experts

1.	Hamilton, Trevor: 2 articles (07/2007 - 10/2004)
2.	Yin, Ruihua: 2 articles (07/2007 - 10/2004)
3.	Magee, Laura A: 2 articles (07/2007 - 10/2004)
4.	Lee, Shoo K: 2 articles (07/2007 - 10/2004)
5.	von Dadelszen, Peter: 2 articles (07/2007 - 10/2004)
6.	Foroozan, Rod: 2 articles (05/2005 - 05/2004)
7.	Celeghin, Alessia: 1 article (11/2015)
8.	Tamietto, Marco: 1 article (11/2015)
9.	de Gelder, Beatrice: 1 article (11/2015)
10.	Büyükcam, Fatih: 1 article (06/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cortical Blindness:

1.	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/01/1988 - "Neurologic abnormalities, including cortical blindness, resolved completely after discontinuation of cyclosporin A. " 05/01/2010 - "Analysis of cyclosporin A-induced reversible cortical blindness by diffusion-weighted magnetic resonance imaging techniques." 02/01/1997 - "We report two cases of encephalopathy with cortical blindness associated with reversible bioccipital lesions in transplanted patients (of the kidney and bone marrow) who were being treated with cyclosporin A. " 02/01/1997 - "[Reversible cortical blindness associated with bilateral occipital lesions caused by cyclosporin A: report of two cases]." 10/08/1994 - "Eighteen cases of cortical blindness during cyclosporin treatment are now known in the literature. "
2.	Carbon MonoxideIBA 01/01/2005 - "The authors found this case of interest because cortical blindness due to CO intoxication is only rarely seen with a relatively good outcome." 01/01/2005 - "Partial recovery from cortical blindness following carbon monoxide intoxication." 02/01/1987 - "We report a case of cortical blindness occurring 7 days after acute CO poisoning with no other neurological or psychic deficits apart from denial of the blindness with visual confabulation and slight loss of retentive memory. " 01/01/2009 - "A 21-year-old woman poisoned with CO (with coma lasting 4 h and carboxyhemoglobin level 46%) developed seizures and cortical blindness 3 days after poisoning. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/2000 - "Several days later, her pneumonia improved on treatment with antibiotics, but she suddenly developed transient cortical blindness and acute renal failure. "
4.	Contrast MediaIBA 01/01/2015 - "Transient cortical blindness after CAG is a rare complication of iodinated contrast agents. " 01/01/2013 - "The prevalence of transient cortical blindness after X-ray contrast media is low and it is usually seen after cerebral angiography. " 06/01/2011 - "Transient cortical blindness is a rare but recognized complication ofintra-arterial injection of iodinated contrast agents." 12/14/2009 - "Cortical blindness is a well described neuro-ophthalmologic complication of angiography due to neurotoxicity following contrast media exposure. " 01/01/1992 - "Low osmolar and non-ionic X-ray contrast media and cortical blindness."
5.	SilverIBA 11/01/1992 - "Golgi-Kopsch silver study of the brain of a patient with untreated phenylketonuria, seizures, and cortical blindness."
6.	iobitridolIBA 01/01/2007 - "Transient cortical blindness after cardiac catheterization with iobitridol." 01/01/2007 - "In this study, we present a case of abrupt cortical blindness after exposure to contrast media during diagnostic coronary angiography; to our knowledge, this is the 1st report in the medical literature that describes transient cortical blindness after iobitridol use."
7.	Retinaldehyde (Retinal)IBA 09/01/2014 - "The most common cause is ischemic optic neuropathy, but it can also be due to central retinal occlusion or cortical blindness. " 04/18/2014 - "Retinal ischemia, cortical blindness, and posterior reversible encephalopathy are also observed, but in a small minority of cases. " 12/01/2013 - "Various pathologies may be responsible for perioperative visual loss (POVL), including ischemic optic neuropathy, retinal vascular occlusion, and cortical blindness. " 11/01/2009 - "Rates of POVL, defined as any discharge with an International Classification of Diseases, Ninth Revision, Clinical Modification code of ischemic optic neuropathy (ION), cortical blindness (CB), or retinal vascular occlusion (RVO), were estimated. " 02/01/2003 - "The differential diagnosis of acute loss of vision in children includes acute loss of vision due to retinal or optic nerve disease, and cortical blindness. "
8.	Cisplatin (Platino)FDA LinkGeneric 01/01/1999 - "Cortical blindness as a manifestation of hypomagnesemia secondary to cisplatin therapy: case report and review of literature." 10/01/1981 - "Cisplatin-associated cortical blindness." 01/01/1993 - "Cortical blindness and seizures following cisplatin treatment: both of epileptic origin?" 02/16/1991 - "Convulsions and transient cortical blindness after cisplatin." 02/15/1980 - "Seizures and transient cortical blindness associated with cis-platinum (II) diamminedichloride (PDD) therapy in a thirty-year-old man."
9.	Tacrolimus (Prograf)FDA LinkGeneric 11/01/1993 - "Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation." 05/01/1999 - "Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation." 05/01/1999 - "A 54-year-old woman with a myelodysplastic syndrome treated with high-dose chemotherapy and an allogenic bone marrow transplant developed acute cortical blindness while receiving tacrolimus (FK506). " 10/01/2004 - "A 46-year-old woman with Hodgkin's disease who underwent nonmyeloablative allogeneic stem cell transplantation developed cortical blindness, seizures, and left hemiparesis on day 100 while receiving tacrolimus (FK506) and prednisone for the treatment of graft-versus-host disease (GVHD). "
10.	Vincristine (Oncovin)FDA LinkGeneric 11/01/2003 - "Transient cortical blindness following vincristine therapy." 08/01/1992 - "The temporal relationship between vincristine treatment and cortical blindness implicates vincristine as the possible causative agent for this catastrophic phenomenon." 08/01/1992 - "Cortical blindness--a catastrophic side effect of vincristine." 01/01/1981 - "Transient cortical blindness has not previously been attributed to vincristine sulfate therapy, but must be considered as a possible complication of treatment with this agent." 01/01/1981 - "Transient cortical blindness secondary to vincristine therapy in childhood malignancies."

Therapies and Procedures

1.	Transplants (Transplant) 10/01/2014 - "Transient cortical blindness: a benign but devastating complication after coronary angiography and graft study." 07/01/2002 - "Transient cortical blindness related to coronary angiography and graft study." 10/01/2014 - "Transient cortical blindness after coronary angiography and bypass graft is a very rare complication. " 07/01/2009 - "Transient cortical blindness is rarely encountered after angiography of native coronary arteries or bypass grafts. " 08/01/2000 - "A 64-year-old man experienced transient cortical blindness after subclavian arteriography for an occluded axillofemoral graft. "
2.	Drug Therapy (Chemotherapy) 03/01/1990 - "Cortical blindness during chemotherapy: clinical, CT, and MR correlations." 01/01/1981 - "Three children with malignancies developed severe neurotoxicity, including transient cortical blindness, following chemotherapy regimens. " 08/01/2006 - "Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor." 07/01/1992 - "VEPs in pediatric patients have the following main purposes: (1) detecting lesions causing dysfunction of the sensory visual pathways (the VEP is a sensitive indicator of subclinical lesions and can be used to differentiate visual impairment from visual inattention in young infants); (2) confirming functional loss when disorders of the visual system are present; (3) quantifying visual impairment in patients with known visual disorders, accomplished either empirically by noting the severity of the VEP abnormality to flash and pattern stimuli or by visual acuity estimation studies (early quantification of vision loss allows referral to early intervention programs, which can ameliorate the long-term consequences of the disability); (4) monitoring patients who are at risk for visual complications either from diseases (such as hydrocephalus or neurofibromatosis) or as a complication of therapeutic intervention (e.g., neurosurgery, chemotherapy) to help detect and avoid long-term sequelae of such therapies on the developing nervous system; (5) establishing prognosis for visual and systemic recovery based on flash VEPs for specific pediatric disorders including perinatal asphyxia in full-term neonates, acute-onset cortical blindness, and, to a fair extent, in comatose children; and (6) in some cases, contributing to the differential diagnosis. " 08/01/1992 - "Cortical blindness was diagnosed in a 67 year old woman with leiomyosarcoma of the large bowel, treated by vincristine-containing chemotherapy. "
3.	Angioplasty (Angioplasty, Transluminal) 10/01/2008 - "We report a case of transient cortical blindness that occurred after coronary angiography and angioplasty performed through the right radial artery. " 10/01/2014 - "In this report we present the case of a 63-year-old man who developed transient cortical blindness within 30 minutes of coronary angioplasty and graft study, but subsequently recovered within 72 hours without any neurological deficit. "
4.	Phototherapy (Light Therapy) 12/01/1996 - "The present study evaluated the effects of bright light therapy on a patient with cortical blindness. "
5.	Catheters 05/01/2005 - "Transient cortical blindness with leptomeningeal enhancement after attempted peripherally inserted central venous catheter placement." 01/01/2005 - "Cortical blindness after catheter angiography." 01/01/2004 - "Transient cortical blindness following intra-arterial catheter angiography is a known rare complication. " 09/01/1988 - "The occurrence of air embolism with neurologic complications during the insertion of central venous catheters is well known, but the development of a cortical blindness has not been stress. " 05/01/1983 - "Most cases of focal brain deficit (other than cortical blindness) are attributed to embolism secondary to the catheter. "