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Hyperlucent Lung (Syndrome, MacLeod)

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A lung with reduced markings on its chest radiograph and increased areas of transradiancy (hyperlucency). A hyperlucent lung is usually associated with pulmonary emphysema or PNEUMOTHORAX.

Also Known As:

Syndrome, MacLeod; Swyer James Syndrome; MacLeod Syndrome; Lung, Hyperlucent; Unilateral Hyperlucent Lung; Hyperlucent Lung, Unilateral; Hyperlucent Lungs; Hyperlucent Lungs, Unilateral; Hyperlucent Thorax; Lung, Unilateral Hyperlucent; Lungs, Hyperlucent; Lungs, Unilateral Hyperlucent; Syndrome, Swyer-James; Unilateral Hyperlucent Lungs; Swyer-James Syndrome; Thorax, Hyperlucent

Networked: 23 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Respiratory Tract Diseases: 445
- Lung Diseases: 12525
  - Pulmonary Emphysema: 1110
    - Hyperlucent Lung: 23

Related Diseases

1.	Atrophy
2.	Pulmonary Tuberculosis
3.	Pneumothorax
4.	Neuroacanthocytosis
5.	Dyskinesias (Dyskinesia)

Experts

1.	Goo, Hyun Woo: 2 articles (01/2011 - 09/2010)
2.	Yang, Dong Hyun: 2 articles (01/2011 - 09/2010)
3.	Burgunder, Jean-Marc: 1 article (07/2014)
4.	Nakajima, Jun: 1 article (01/2014)
5.	Sano, Atsushi: 1 article (01/2014)
6.	Fukami, Takeshi: 1 article (01/2014)
7.	Murakawa, Tomohiro: 1 article (01/2014)
8.	Takeuchi, Muneyuki: 1 article (05/2013)
9.	Metin, Bayram: 1 article (05/2013)
10.	Kinouchi, Keiko: 1 article (05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperlucent Lung:

1.	XenonIBA 01/01/2011 - "Xenon-enhanced dynamic dual-energy CT can help visualize and quantitate various degrees of collateral ventilation to congenital hyperlucent lung lesions in addition to assessing the anatomic details of the lung." 01/01/2011 - "Xenon-enhanced dynamic dual-energy CT was successfully and safely performed in eight children (median age: 5.5 years, 4 boys and 4 girls) with congenital hyperlucent lung lesions. " 01/01/2011 - "We wanted to evaluate the resistance to collateral ventilation in congenital hyperlucent lung lesions and to correlate that with the anatomic findings on xenon-enhanced dynamic dual-energy CT. " 01/01/2011 - "Collateral ventilation to congenital hyperlucent lung lesions assessed on xenon-enhanced dynamic dual-energy CT: an initial experience." 09/01/2010 - "Volume percentages of xenon ventilation defects (35.0 +/- 16.4%) were not significantly different from those of hyperlucent lung regions (38.2 +/- 18.6%). "
2.	Congenital lobar emphysemaIBA 10/01/1990 - "An unusual case of congenital lobar emphysema diagnosed in a young adult following the initial discovery of a hyperexpanded, hyperlucent lung is reported. " 05/01/2011 - "Unilateral hyperlucent hemithorax has a broad differential diagnosis that includes unilateral emphysematous or bullous disease, pneumatocele, foreign body aspiration, Swyer-James syndrome, congenital lobar emphysema, endobronchial mass, unilateral pulmonary agenesis, proximal interruption of the pulmonary artery, scimitar syndrome, diaphragmatic hernia, and Poland syndrome. "
3.	tranilast (N 5')IBA 01/01/1988 - "On the basis of comprehensive clinicopathological evidence 6 patients presenting with unilateral left-sided hyperlucent lungs are evaluated for pathogenesis, function and postoperative (n = 5) course. " 12/01/2000 - "Chest X-ray findings could be divided into four distinct patterns that were hyperinflation (n=5), mixed pattern of atelectasis, hyperlucency and bronchial thickening (n=4), unilateral small hyperlucent lung (n=3) and unilateral collapse of one lung (n=2). "
4.	Proline (L-Proline)FDA Link 07/01/2014 - "Several syndromes with similar presentation have different genetic backgrounds, including the neuroacanthocytoses, mainly choreoacanthocytosis and MacLeod syndrome as a result of mutations in chorein and Kell protein, respectively, but also benign hereditary chorea, owing to mutations in NKX-2-1, and paroxysmal kinesigenic dyskinesia, as a result of recently found mutations in the proline-rich transmembrane protein 2, PRRT2. "
5.	CarcinogensIBA 09/01/1993 - "It is suggested that the bronchial epithelium of the unaffected lung in Swyer-James syndrome is likely to be more exposed to extrinsic carcinogens than that of the affected, underventilated lung, hence resulting in a higher risk of developing bronchogenic carcinoma."
6.	CalciumIBA 01/01/1988 - "Hyperlucent lung due to a calcium-containing bronchogenic cyst."
7.	Adenocarcinoma of lungIBA 09/01/1994 - "Primary lung adenocarcinoma complicated with Swyer-James syndrome was diagnosed, and left pneumonectomy done. "
8.	Lung agenesisIBA 05/01/2011 - "Unilateral hyperlucent hemithorax has a broad differential diagnosis that includes unilateral emphysematous or bullous disease, pneumatocele, foreign body aspiration, Swyer-James syndrome, congenital lobar emphysema, endobronchial mass, unilateral pulmonary agenesis, proximal interruption of the pulmonary artery, scimitar syndrome, diaphragmatic hernia, and Poland syndrome. "
9.	Idiopathic pulmonary hypertensionIBA 01/01/2011 - "Here we report the case of a 53-year-old Caucasian woman with Swyer-James-MacLeod syndrome found in the differential diagnosis workup for a new onset of heart failure, secondary to pulmonary arterial hypertension complicated by a patent ductus arteriosus. "
10.	tebufenozide (Mimic)IBA 02/01/2003 - "Swyer-James-Macleod syndrome has a diverse manifestations in adults and can mimic other pulmonary disorders, which may lead to incorrect diagnosis and inappropriate therapy. "

Therapies and Procedures

1.	Neck Dissection (Radical Neck Dissection) 11/01/1994 - "In the radiographs, eight patients had a hyperlucent thorax on the side of the neck dissection. " 11/01/1994 - "The purpose of this study was to assess the prevalence and mechanisms that may be responsible for unilateral hyperlucency of the thorax after neck dissection and to determine if atrophy of the trapezius due to the transection of the accessory nerve is a cause of hyperlucent thorax. " 11/01/1994 - "Our findings show that atrophy of the denervated trapezius muscle after neck dissection is a cause of unilateral hyperlucent thorax on plain chest radiographs. " 11/01/1994 - "Unilateral hyperlucent thorax on plain chest radiographs after neck dissection: importance of atrophy of the trapezius muscle."
2.	Pneumonectomy (Lung Volume Reduction) 07/01/2005 - "Lung volume reduction surgery for a professional athlete with Swyer-James syndrome." 09/01/1994 - "Morphological features of Swyer-James syndrome were studied in a specimen obtained during left pneumonectomy. " 11/01/2002 - "Clinical, physiologic, and roentgenographic changes after pneumonectomy in a boy with Macleod/Swyer-James syndrome and bronchiectasis." 09/01/1994 - "Primary lung adenocarcinoma complicated with Swyer-James syndrome was diagnosed, and left pneumonectomy done. "
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 08/01/2010 - "Swyer-James syndrome or destroyed lung?/Coronary artery bypass in a patient with Swyer-James syndrome due to pulmonary tuberculosis." 04/01/2010 - "Coronary artery bypass in a patient with Swyer-James syndrome due to pulmonary tuberculosis."
4.	Pleurodesis 01/01/2014 - "To prevent the recurrence of pneumothorax related to Swyer-James syndrome, some kind of procedure, such as extensive pleurodesis, is necessary. "
5.	Chest Tubes (Chest Tube) 05/01/2013 - "Swyer-James-MacLeod syndrome with renal ectopy misdiagnosed as pneumothorax and chest tube drained: Case study."