Alcoholic Pancreatitis

Acute or chronic INFLAMMATION of the PANCREAS due to excessive ALCOHOL DRINKING. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.

Also Known As:

Networked: 213 relevant articles (7 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pancreatitis
2.	Pathologic Constriction (Stenosis)
3.	Chronic Pancreatitis
4.	Abdominal Pain (Pain, Abdominal)
5.	Alcoholism (Alcohol Abuse)

Experts

1.	Apte, Minoti V: 3 articles (05/2014 - 01/2004)
2.	Whitcomb, David C: 3 articles (09/2012 - 07/2002)
3.	Gaisano, Herbert Y: 3 articles (09/2012 - 04/2007)
4.	Nichitaĭlo, M E: 2 articles (02/2013 - 07/2012)
5.	Kravchenko, D A: 2 articles (02/2013 - 07/2012)
6.	Gukovskaya, Anna S: 2 articles (02/2013 - 11/2003)
7.	Savitskaia, I M: 2 articles (02/2013 - 07/2012)
8.	Shpon'ka, I S: 2 articles (02/2013 - 07/2012)
9.	Pandol, Stephen J: 2 articles (02/2013 - 11/2003)
10.	Medvetskiĭ, E B: 2 articles (02/2013 - 07/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alcoholic Pancreatitis:

1.	AmylasesFDA Link 03/01/1988 - "We conclude that there may be a subset of patients with mild exacerbation of recurrent alcoholic pancreatitis, identifiable by a low serum amylase level, who would benefit from a trial of management in an emergency department observation unit." 12/01/2009 - "Based on an elevated serum amylase level and abdominal computed tomography findings, a diagnosis of alcoholic pancreatitis was made. " 07/01/2008 - "In WT mice, in vitro EtOH exposure or EtOH diet reduced Cch-stimulated amylase release by redirecting apical exocytosis to the basolateral membrane, leading to alcoholic pancreatitis. " 12/01/1994 - "A normal serum amylase level is found in up to 32% of patients with acute alcoholic pancreatitis. " 09/01/1993 - "The low turnover rates may be ascribed to continuing pancreatic cell malfunction after recovery from acute alcoholic pancreatitis and suggest that the decreased amylase secretion rates are partly a consequence of impaired amylase synthesis and not simply because of loss of pancreatic tissue."
2.	Cimetidine (Biomet)FDA LinkGeneric 07/01/1984 - "A double-blind prospective controlled study designed to determine the effectiveness of the addition of cimetidine to standard treatment of acute alcoholic pancreatitis and to determine the importance of nasogastric suction in this disorder was undertaken. " 07/01/1984 - "Treatment of acute alcoholic pancreatitis: the roles of cimetidine and nasogastric suction." 10/01/1979 - "A double-blind study was made of the comparative effectiveness of cimetidine in the treatment of acute alcoholic pancreatitis. " 10/01/1979 - "Cimetidine in the treatment of acute alcoholic pancreatitis. " 07/01/1984 - "It was concluded that 1) cimetidine added to more traditional therapy does not hasten improvement in patients with acute alcoholic pancreatitis, 2) cimetidine may delay recovery as measured by both clinical and biochemical measurements, 3) nasogastric suction appears indicated, under most circumstances, only in those patients with ileus and/or nausea and emesis."
3.	Proteins (Proteins, Gene)IBA 03/01/2008 - "Scope remains for further studies examining proteins related to cellular anti-oxidant defenses, minor cystic fibrosis (CF) mutations and trans-heterozygosity involving a combination of mutations of different genes (such as CFTR alterations combined with SPINK1 or PRSS1 variants), as potential triggers of alcoholic pancreatitis." 01/01/1987 - "We measured the renal clearance of three low molecular weight proteins (amylase, beta 2-microglobulin, and lysozyme) and urinary excretion of three lysosomal enzymes that originate from the renal tubule in three groups of patients (alcoholic pancreatitis, pancreatitis without alcoholism, and alcoholism without pancreatitis). "
4.	EnzymesIBA 07/01/2009 - "Abusing of alcohol induces changes in pancreatic digestive enzymes secretion, what contributes to development of chronic alcoholic pancreatitis. " 07/01/2002 - "Because CEL has fatty acid ethyl ester (FAEE)-generating activity and FAEEs play a major role in acute alcoholic pancreatitis, we determined the expression of other genes encoding for FAEE-generating enzymes and showed similar organ-specific expression patterns. " 04/01/1999 - "These data suggest that the risk of chronic alcoholic pancreatitis diagnosed clinically and pathologically seems to be associated with the ADH 2(2) allele in the genotypes of alcohol-metabolizing enzymes." 07/19/1997 - "Postulated mechanisms of alcoholic pancreatitis include (i) zymogen granule fragility facilitating intracellular activation of digestive enzymes and (ii) ductular obstruction by protein plugs. " 10/01/1994 - "It is proposed that zymogen granule fragility may play an early part in the pathogenesis of alcoholic pancreatitis by permitting contact between digestive and lysosomal enzymes."
5.	PancreatinIBA 09/17/1995 - "The authors concluded that this new product is a good pancreatin preparation which is useful and suitable for effective treatment of chronic alcoholic pancreatitis, if the patient keeps abstinence." 09/17/1995 - "They introduce a new product of pancreatin use for treatment of chronic alcoholic pancreatitis. " 09/17/1995 - "[Treatment of chronic alcoholic pancreatitis with a new acid-resistant pancreatin product]."
6.	Muramidase (Lysozyme)IBA 01/01/1987 - "We measured the renal clearance of three low molecular weight proteins (amylase, beta 2-microglobulin, and lysozyme) and urinary excretion of three lysosomal enzymes that originate from the renal tubule in three groups of patients (alcoholic pancreatitis, pancreatitis without alcoholism, and alcoholism without pancreatitis). "
7.	GelatinIBA 05/07/2005 - "This case confirms that superselective transcatheter embolization by PVA and gelatin sponge particles may represent an effective treatment for pseudoaneurysm caused by chronic alcoholic pancreatitis in the absence of other therapeutic alternatives." 05/07/2005 - "To assess the effectiveness of and complications associated with polyvinyl alcohol (PVA) and gelatin sponge particles embolization of splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis. " 05/07/2005 - "Polyvinyl alcohol and gelatin sponge particle embolization of splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis."
8.	beta 2-Microglobulin (beta 2 Microglobulin)IBA 01/01/1987 - "We measured the renal clearance of three low molecular weight proteins (amylase, beta 2-microglobulin, and lysozyme) and urinary excretion of three lysosomal enzymes that originate from the renal tubule in three groups of patients (alcoholic pancreatitis, pancreatitis without alcoholism, and alcoholism without pancreatitis). "
9.	AntioxidantsIBA 09/01/2009 - "Researchers this last year have further characterized clinical aspects of chronic pancreatitis that may lead to improved detection of early chronic pancreatitis and AIP, risk stratification and application of risk-lowering strategies to prevent relapses in AIP or the development of recurrent (and possibly chronic) alcoholic pancreatitis and new evidence that antioxidants may have a modest effect on reducing the dominant symptom in chronic pancreatitis, abdominal pain."
10.	Ethanol (Ethyl Alcohol)IBA 01/01/2010 - "This study shows that alcoholic pancreatitis is induced by the combination of ethanol and individual cofactors. " 08/01/2010 - "To understand the mechanism of alcoholic pancreatitis, we evaluated dose-dependent metabolism of ethanol and related pancreatic injury in ADH(-) and hepatic ADH-normal (ADH(+)) deer mice fed 1%, 2% or 3.5% ethanol via Lieber-DeCarli liquid diet daily for 2months. " 11/01/2007 - "The pancreas is vulnerable to ethanol toxicity, but the pathogenesis of alcoholic pancreatitis is not fully defined. " 11/24/2006 - "Our observations provide a mechanistic understanding of the role of ethanol in the initiation phase of alcoholic pancreatitis." 10/01/2005 - "[Ethanol metabolism in pancreas and its role in alcoholic pancreatitis]."

Therapies and Procedures

1.	Stents 05/01/2000 - "The aim of this study is to analyze the frequency and severity of complications caused by biliary stents in patients with chronic alcoholic pancreatitis. " 05/01/2000 - "High complication rate of bile duct stents in patients with chronic alcoholic pancreatitis due to noncompliance." 05/01/2005 - "For several years, she had chronic alcoholic pancreatitis with ductal stones that were treated with a stent and with shockwave lithotripsy. " 01/01/2008 - "Alcoholic pancreatitis was diagnosed and responded well to pancreatic stricture dilatation with stent insertion. "
2.	Pancreaticoduodenectomy 04/01/1993 - "This report consists of a small group of well-defined patients with recurrent episodes of alcoholic pancreatitis who benefited from pancreaticoduodenectomy. " 04/01/1993 - "Pancreaticoduodenectomy for recurrent alcoholic pancreatitis associated with microabscesses." 08/01/1993 - "Here we report a patient with annular pancreas, chronic alcoholic pancreatitis and gastric carcinoma, who was successfully treated by radical proximal pancreatoduodenectomy."
3.	Pancreatectomy 04/01/2013 - "Should pancreatectomy with islet cell autotransplantation in patients with chronic alcoholic pancreatitis be abandoned?" 05/01/1989 - "The patient had a history of alcoholic pancreatitis for which she underwent a subtotal pancreatectomy. " 04/01/1977 - "The preoperative use of ERCP and individualization of operative procedures with a preference for subtotal or partial pancreatectomy for symptomatic chronic alcoholic pancreatitis are supported." 04/01/1977 - "Of 22 patients treated surgically for intractable pain from chronic alcoholic pancreatitis, eight did not show notable dilation of the main pancreatic duct by endoscopic retrograde cholangiopancreatography (ERCP), operative pancreatography, and/or operative and microscopical studies of the pancreas after subtotal pancreatectomy. " 04/01/2013 - "Outcomes of 100 patients who underwent pancreatectomy with islet isolation between 2005 and 2012 were assessed by etiology (alcoholic pancreatitis [AP] 30%, and nonalcoholic pancreatitis [NAP] 70%). "
4.	Lasers (Laser) 07/01/1999 - "Microcirculation in chronic alcoholic pancreatitis: a laser Doppler flow study." 01/01/2000 - "Effectiveness of dalargin and intravenous laser blood beaming (ILBB) in combined treatment of chronic alcoholic pancreatitis (CAP) was studied in 105 patients (8 females and 97 males) with CAP duration 1 to 25 years. "
5.	Peritoneal Dialysis 05/01/1983 - "In a prospective, randomized trial involving 11 patients, thoracic duct drainage failed to equal the immediate and reliable benefit gained by peritoneal dialysis in the treatment of severe alcoholic pancreatitis. "