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Vasovagal Syncope

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Loss of consciousness due to a reduction in blood pressure that is associated with an increase in vagal tone and peripheral vasodilation.

Also Known As:

Syncope, Vasovagal; Neurally Mediated Faint; Syncope, Cerebral; Syncope, Malignant Neurocardiogenic; Syncope, Supine; Syncope, Vasovagal, Neurally-Mediated; Cerebral Syncope; Cerebral Syncopes; Faint, Neurally Mediated; Faints, Neurally Mediated; Malignant Neurocardiogenic Syncope; Malignant Neurocardiogenic Syncopes; Neurally Mediated Faints; Neurocardiogenic Syncope; Neurocardiogenic Syncope, Malignant; Neurocardiogenic Syncopes; Neurocardiogenic Syncopes, Malignant; Neurogenic Syncope; Neurogenic Syncopes; Supine Syncope; Supine Syncopes; Syncopes, Cerebral; Syncopes, Malignant Neurocardiogenic; Syncopes, Neurocardiogenic; Syncopes, Neurogenic; Syncopes, Supine; Syncopes, Vasodepressor; Syncopes, Vasovagal; Vasodepressor Syncope; Vasodepressor Syncopes; Vasovagal Syncopes; Syncope, Neurocardiogenic; Syncope, Neurogenic; Syncope, Vasodepressor

Networked: 349 relevant articles (57 outcomes, 67 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Syncope (Fainting)
2.	Orthostatic Hypotension (Postural Hypotension)
3.	Atrioventricular Block
4.	Bradycardia
5.	Heart Arrest (Cardiac Arrest)

Experts

1.	Wieling, Wouter: 5 articles (11/2011 - 02/2005)
2.	Jin, Hongfang: 4 articles (04/2015 - 04/2008)
3.	Du, Junbao: 4 articles (04/2015 - 04/2008)
4.	Cárdenas, Manuel: 4 articles (09/2013 - 08/2005)
5.	Márquez, Manlio F: 4 articles (09/2013 - 08/2005)
6.	Ritchie, Debbie: 4 articles (07/2013 - 03/2006)
7.	Sheldon, Robert S: 4 articles (07/2013 - 08/2009)
8.	Mitro, P: 4 articles (01/2009 - 12/2000)
9.	Kenny, R A: 3 articles (09/2015 - 03/2001)
10.	Brignole, Michele: 3 articles (08/2015 - 09/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vasovagal Syncope:

1.	Midodrine (Midon)FDA LinkGeneric 12/01/2012 - "This study will be the first adequately powered trial to determine whether midodrine is effective in preventing vasovagal syncope. " 10/01/2010 - "Midodrine hydrochloride is safe and effective in older people with neurocardiogenic syncope." 05/01/1994 - "Midodrine's ability to vasoconstrict without increasing heart rate suggests that it might be a useful treatment for vasovagal syncope since stimulation of the Bezold-Jarisch reflex would be less likely. " 08/01/2001 - "The efficacy of midodrine for the management of patients with neurocardiogenic syncope was assessed prospectively in a randomized control study. " 07/28/2009 - "To explore the efficacy of midodrine hydrochloride in the treatment of vasovagal syncope (VVS) in children. "
2.	Atenolol (Tenormin)FDA LinkGeneric 12/01/1995 - "In conclusion, atenolol significantly improved symptoms of patients with vasovagal syncope.(ABSTRACT TRUNCATED AT 250 WORDS)" 02/01/2001 - "This study was designed to evaluate the efficacy of atenolol for the long-term management of patients with vasovagal syncope. " 02/01/2001 - "The recurrence of neurocardiogenic syncope in highly symptomatic patients treated with atenolol is similar to that of patients treated with placebo." 02/01/2001 - "The primary hypothesis was that atenolol is not superior to placebo for the treatment of vasovagal syncope. " 12/01/1995 - "The objective of this investigation was the assessment of the response rate of oral atenolol in patients with vasovagal syncope after 1 month of treatment. "
3.	Metoprolol (Lopressor)FDA LinkGeneric 02/01/1994 - "We conclude that metoprolol is safe and effective for the treatment of most cases of neurocardiogenic syncope in children and that this response cannot be predicted accurately by the use of intravenous metoprolol during testing." 12/01/1998 - "Many aspects of this clinical setting are similar to tilttable testing for patients with recurrent vasovagal syncope, in which beta-adrenergic blockade with metoprolol has also been shown to be effective. " 05/15/2007 - "To investigate the value of hemodynamic changes during head-up tilt (HUT) test and predictive value thereof in evaluating the efficacy of metoprolol therapy in children with vasovagal syncope (VSS). " 05/15/2007 - "[Hemodynamic changes during head-up tilt test and predictive value thereof in predicting the efficacy of metoprolol therapy in children with vasovagal syncope]." 03/07/2006 - "Metoprolol was not effective in preventing vasovagal syncope in the study population."
4.	Serotonin (5 Hydroxytryptamine)IBA 12/01/1999 - "Serotonergic mechanisms may play a major role in the pathophysiology of neurocardiogenic syncope, and serotonin re-uptake inhibitors have been recently reported to be effective in preventing episodes. " 01/01/2010 - "To investigate clinical features of childhood vasovagal syncope (VVS) and the possible relationship between changes of plasma and platelet 5-hydroxytryptamine (5-HT) and childhood VVS. " 01/01/2010 - "[Clinical features and changes of 5-hydroxytryptamine in children with vasovagal syncope]." 08/01/1994 - "The serotonin reuptake inhibitor sertraline hydrochloride can be effective in preventing recurrent neurocardiogenic syncope in selected patients unresponsive to or intolerant of other therapeutic modalities." 08/01/1994 - "The serotonin reuptake inhibitor fluoxetine hydrochloride has been reported to be effective in preventing neurocardiogenic syncope in adults. "
5.	Propranolol (Inderal)FDA LinkGeneric 11/01/1995 - "Intravenous propranolol is effective in preventing neurocardiogenic syncope diagnosed during head-up tilt testing and predicts the response to oral beta-blocker therapy. " 08/01/1998 - "Nevertheless, the effects of tilt test on vasovagal syncope have never been compared with those obtained by ethylephrine or propranolol administration. " 08/01/1998 - "Because these patients had negative electrophysiological studies, positive tilt tests, and absent syncope after oral propranolol therapy, they were considered as having neurocardiogenic syncope. " 02/01/1994 - "The syncope associated with hypotension and bradycardia was reproduced by upright posture for 8 min. This neurocardiogenic syncope was prevented by propranolol (30 mg/day). " 03/01/2006 - "To compare the therapeutic efficacy of placebo, propranolol, and fluoxetine in patients with vasovagal syncope (VVS). "
6.	Sertraline (Zoloft)FDA LinkGeneric 08/01/1994 - "Use of sertraline hydrochloride in the treatment of refractory neurocardiogenic syncope in children and adolescents." 10/01/1997 - "Vasovagal syncope: asystole provoked by head-up tilt testing under sertraline therapy." 10/01/1997 - "Sertraline hydrochloride may be useful in preventing recurrent neurocardiogenic syncope resistant to standard pharmacotherapy but careful clinical studies are essential before such a treatment strategy can be recommended since serious asystole could develop." 08/01/1994 - "The serotonin reuptake inhibitor sertraline hydrochloride can be effective in preventing recurrent neurocardiogenic syncope in selected patients unresponsive to or intolerant of other therapeutic modalities." 08/01/1994 - "The purpose of our study was to determine whether the serotonin reuptake inhibitor sertraline hydrochloride could prevent neurocardiogenic syncope in children and adolescents resistant to or intolerant of other therapies. "
7.	Pindolol (LB 46)FDA LinkGeneric 10/01/1995 - "In conclusion, pindolol appears to be safe and effective as initial treatment for vasovagal syncope." 11/01/2004 - "This study evaluated the efficacy of pindolol, a noncardioselective beta blocker with intrinsic sympathetic activity, on neurocardiogenic syncope using a head-up tilt-table test in 66 patients. " 10/01/1995 - "Efficacy of pindolol for treatment of vasovagal syncope." 10/01/1995 - "The purpose of this study was to evaluate the efficacy, safety, and tolerance of pindolol as initial therapy for vasovagal syncope. " 11/01/2004 - "Usefulness of pindolol for treatment of neurocardiogenic syncope."
8.	Adrenergic Antagonists (Antiadrenergic Agents)IBA 01/01/2010 - "Clinical efficacy of beta1 selective adrenergic blockers in the treatment of neurocardiogenic syncope - a meta-analysis." 02/01/1992 - "Use of intravenous esmolol to predict efficacy of oral beta-adrenergic blocker therapy in patients with neurocardiogenic syncope." 11/01/1998 - "We prospectively studied the efficacy of pindolol, a beta-adrenergic blocker with intrinsic sympathomimetic activity (ISA), for the prevention of syncope recurrences in 31 patients with recurrent neurocardiogenic syncope. "
9.	Nitroglycerin (Dynamite)FDA LinkGeneric 01/01/2004 - "The aim of our study was to assess the efficacy of the HUTT with sublingual nitroglycerin (NTG) challenge for the diagnosis of vasovagal syncope. " 01/01/2004 - "Study of the efficiency of the head-up tilt test with nitroglycerin challenge in the diagnosis of vasovagal syncope." 08/01/2003 - "Three hundred and fifteen patients undergoing diagnostic tilt table testing potentiated with nitroglycerin for suspected neurocardiogenic syncope were included in the study. " 08/01/1995 - "This study was undertaken to assess the value of sublingual nitroglycerin administration during upright tilt as a simple practical test for the diagnosis of vasovagal syncope. " 01/01/1994 - "The aim of our present study was to assess the value of nitroglycerin infusion during upright posture as a new provocative test for diagnosis of vasovagal syncope. "
10.	Paroxetine (Paxil)FDA LinkGeneric 12/01/1999 - "Paroxetine significantly improved symptoms of young patients with recurrent vasovagal syncope unresponsive to or intolerant of traditional medications and was well tolerated by patients." 12/01/1999 - "[Effectiveness of paroxetine in the treatment of refractory vasovagal syncope in young patients]." 04/01/1999 - "Paroxetine was found to significantly improve the symptoms of patients with vasovagal syncope unresponsive to or intolerant of traditional medications and was well tolerated by patients." 12/01/1999 - "The aim of the study was to assess whether the well-tolerated serotonin re-uptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in young patients resistant to or intolerant of previous traditional therapies. " 04/01/1999 - "The purpose of the study was to determine whether the well tolerated serotonin reuptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in patients resistant to or intolerant of previous traditional therapies. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 11/01/2003 - "Home orthostatic self-training, up to 30 min once daily following an initial twice daily program, was highly effective in the suppression of recurrent neurocardiogenic syncope in patients intolerant of, or refractory to standard drug therapy." 10/01/2001 - "While drug therapy for vasovagal syncope is still controversial, recently two randomized studies revealed the efficacy of dual-chamber pacemaker implantation in decreasing recurrences in very symptomatic patients. " 11/01/2003 - "STUDY OBJECTIVE AND METHODS: This study examined the effectiveness of orthostatic self-training in 15 patients with head-up tilt testing (HUT)-inducible neurocardiogenic syncope, who were intolerant of, or refractory to standard drug therapy. " 12/01/2000 - "Cardiostimulation in used less frequently than pharmacotherapy in the treatment of vasovagal syncope. " 12/01/2000 - "Provisions regarding the regimen, non-pharmacological treatment and pharmacotherapy are the basic principles of management of patients with vasovagal syncope. "
2.	Fluid Therapy (Oral Rehydration Therapy) 02/01/1998 - "Our data suggest that oral fluid therapy is an effective treatment for vasodepressor syncope in our population. " 04/01/2015 - "Oral rehydration salts: an effective choice for the treatment of children with vasovagal syncope." 04/01/2015 - "To explore whether oral rehydration salts (ORS) is effective in the treatment of children with vasovagal syncope (VVS). "
3.	Lower Body Negative Pressure 01/01/2015 - "Five women developed symptoms of vasovagal syncope (orthostatic intolerant) and were compared with the remaining women, who tolerated LBNP well (orthostatic tolerant). " 03/01/1997 - "Tolerance to lower body negative pressure exposure: comparison between patients with neurocardiogenic syncope and controls." 01/21/1997 - "In patients with vasovagal syncope, during the application of subhypotensive LBNP, there is impaired forearm vasoconstriction or paradoxical forearm vasodilation. " 01/21/1997 - "In patients with vasovagal syncope, during the application of -10 mm Hg LBNP, forearm vascular resistance decreased by 0.7 +/- 11.6 U versus an increase of 8.3 +/- 6.2 U in control subjects (P = .002). " 03/01/1996 - "First, we tested the hypothesis that reflex constriction of the venous capacitance beds in patients with vasovagal syncope is impaired during both subhypotensive lower-body negative pressure. "
4.	Catheters 01/01/2005 - ""Cardioneuroablation"--new treatment for neurocardiogenic syncope, functional AV block and sinus dysfunction using catheter RF-ablation." 09/01/2009 - "[Case of neurocardiogenic syncope with asystole during insertion of epidural catheter]." 04/01/1991 - "With an experimental laboratory stressor (cognitive challenge), we noted a preferential activation of the cardiac sympathetic outflow; however, in fainting reactions ("vasovagal syncope"), which occur infrequently during the course of central venous catheter placement under local anesthesia, the converse was seen--an almost total withdrawal of cardiac sympathetic activity. " 01/01/1989 - "Three male runners developed symptoms of vasovagal syncope after the catheter placement and had high initial B-EN, ACTH, and cortisol concentrations which decreased throughout the run. "
5.	Radiotherapy 01/01/2012 - "We present a rare cause of recurrent vasovagal syncope with predominant cardioinhibitory response due to lymphoma surrounding and compressing the carotid artery treated successfully with radiotherapy."