Integrases

Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.

Also Known As:

Networked: 357 relevant articles (7 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Engelman, Alan: 14 articles (04/2014 - 01/2004)
2.	Hazuda, Daria J: 9 articles (10/2014 - 02/2003)
3.	Calos, Michele P: 8 articles (04/2012 - 06/2003)
4.	Pommier, Yves: 6 articles (01/2016 - 03/2006)
5.	Marchand, Christophe: 6 articles (01/2016 - 03/2006)
6.	Wainberg, Mark A: 5 articles (10/2015 - 01/2010)
7.	Li, Xiang: 5 articles (04/2014 - 12/2008)
8.	Ronfort, Corinne: 5 articles (12/2011 - 11/2003)
9.	Moreau, Karen: 5 articles (12/2011 - 11/2003)
10.	Rowley, Michael: 5 articles (03/2011 - 05/2007)

Related Diseases

1.	Infection 01/01/2015 - "Clinical studies have shown that integrase strand transfer inhibitors (INSTIs) can be used effectively against HIV-1 infection. " 08/01/2015 - "The aim of this multiple-hospital study was to investigate the prevalence of integrons in multidrug-resistant Acinetobacter baumannii (MDRAB) in Eastern China, and characterize the integron-integrase genes, so as to provide evidence for the management and appropriate antibiotic use of MDRAB infections. " 07/07/2015 - "When correlated with outcomes in the iPrEx trial, Vif- and Integrase-specific T-cell responses were associated with reduced HIV-1 infection risk [hazard ratio (HR) = 0.36, 95% confidence interval (95% CI) = 0.19-0.66 and HR = 0.52, 95% CI = 0.28-0.96, respectively]. " 01/01/2015 - "Although our sample size was small, this study does not support the need at this time to evaluate integrase mutations as part of routine consensus sequencing among persons newly diagnosed with HIV-1 infection. " 01/01/2013 - "Clinical studies have shown that integrase strand transfer inhibitors can be used to treat HIV-1 infection. "
2.	HIV Infections (HIV Infection) 02/01/2009 - "Integrase (IN) inhibitors have proven to be highly beneficial in the treatment of HIV infection. " 01/01/2016 - "Genotypic drug resistance testing for HIV-1 has been integrated into voluntary counselling and testing (VCT) programmes to investigate the trends of transmitted drug resistance (TDR), including integrase mutations, among individuals with recent or chronic HIV infections in Taiwan. " 02/01/2015 - "Three integrase (IN) inhibitors have been approved by FDA for clinical treatment of Human Immunodeficiency Virus (HIV) infection. " 01/01/2015 - "To compare central nervous system (CNS) outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART) vs. cART plus integrase inhibitor and CCR5 antagonist (cART+). " 01/01/2015 - "Dolutegravir is the newest integrase strand transfer inhibitor to be approved for the treatment of human immunodeficiency virus (HIV) infection. "
3.	Urticaria (Hives) 12/01/2011 - "In this review, the author presents a case of autoimmune CIU (chronic idiopathic urticaria) in stable remission after therapy with a retroviral integrase inhibitor, raltegravir (Isentress). "
4.	Rheumatoid Arthritis 08/01/2006 - "The ability of phiC31 integrase to facilitate genomic integration in synovial cells and increase transgene expression in the rabbit synovium suggests that, in combination with more efficient DNA delivery methods, this integrase system could be beneficial for treatment of rheumatoid arthritis and other joint disorders."
5.	Neoplasms (Cancer) 01/01/2010 - "To study whether hydrodynamic delivery alone, or in conjunction with delivery of phiC31 integrase for long-term transgene expression, could facilitate tumor formation, we used a transgenic mouse model in which sustained induction of the human C-MYC oncogene in the liver was followed by hydrodynamic injection. " 09/01/2013 - "The rhabdoid component also demonstrated the loss of immunostaining for integrase interactor 1 (INI1), which stained the other components of the tumor. " 04/01/2013 - "Wingless/integrase-1 (WNT) signaling is a key pathway regulating various aspects of embryonic development; however it also underlies several pathological conditions in man, including various cancers and fibroproliferative diseases in several organs. " 01/01/2012 - "In order to alleviate this bottleneck, we characterized the potential utility of a novel PhiC31 integrase-mediated site-specific insertion system (PhiC31-IMSI) for introduction of transgenes into a pre-inserted docking site in the genome of cancer cells. " 01/01/2010 - "Our data suggest that phiC31 integrase does not facilitate tumor formation in this C-MYC transgenic mouse model. "

Related Drugs and Biologics

1.	MK 0518
2.	DNA (Deoxyribonucleic Acid)
3.	Human immunodeficiency virus 1 reverse transcriptase
4.	triphosphoric acid (triphosphate)
5.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
6.	Glycoproteins (Glycoprotein)
7.	Proteins (Proteins, Gene)
8.	Viral DNA
9.	Protease Inhibitors (Protease Inhibitor)
10.	Enzymes

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
2.	Therapeutics
3.	Immunotherapy
4.	Intramuscular Injections
5.	Drug Therapy (Chemotherapy)