Integrases

Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.

Also Known As:

Networked: 601 relevant articles (20 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Engelman, Alan: 14 articles (04/2014 - 01/2004)
2.	Calos, Michele P: 9 articles (04/2016 - 06/2003)
3.	Cara, Andrea: 8 articles (01/2021 - 01/2005)
4.	Castagna, Antonella: 7 articles (03/2022 - 02/2011)
5.	Burke, Terrence R: 7 articles (11/2021 - 02/2014)
6.	Cherepanov, Peter: 7 articles (11/2021 - 06/2006)
7.	Hughes, Stephen H: 7 articles (11/2021 - 02/2014)
8.	Zhao, Xue Zhi: 7 articles (11/2021 - 02/2014)
9.	Koethe, John R: 7 articles (10/2021 - 12/2017)
10.	Lake, Jordan E: 7 articles (10/2021 - 01/2014)

Related Diseases

1.	Infections 01/01/2024 - "Thus, HTLV-1 integrase is considered an attractive therapeutic target; however, no clinically effective inhibitors are available to treat HTLV-1 infection. " 01/01/2021 - "Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1) infection. " 01/01/2015 - "Clinical studies have shown that integrase strand transfer inhibitors (INSTIs) can be used effectively against HIV-1 infection. " 01/01/2019 - ": Although integrase strand transfer inhibitors (INSTIs) are widely used in HIV-1 group M (HIV-1/M) infections, little is known about their efficacy against genetically divergent HIV-1 group O (HIV-1/O) strains. " 07/07/2015 - "When correlated with outcomes in the iPrEx trial, Vif- and Integrase-specific T-cell responses were associated with reduced HIV-1 infection risk [hazard ratio (HR) = 0.36, 95% confidence interval (95% CI) = 0.19-0.66 and HR = 0.52, 95% CI = 0.28-0.96, respectively]. "
2.	HIV Infections (HIV Infection) 01/01/2016 - "Integrase strand transfer inhibitors (INSTIs) are highly effective against HIV infections. " 02/01/2009 - "Integrase (IN) inhibitors have proven to be highly beneficial in the treatment of HIV infection. " 01/01/2021 - "The integrase strand transfer inhibitor (INSTI)-containing regimens are currently considered as the first-line treatment of human immunodeficiency virus (HIV) infection. " 01/01/2020 - "The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for an improved understanding of viral genetic variability in the occurrence of drug resistance (DR). " 01/01/2023 - "Of 19 HIV infections among those randomized to CAB-LA with results available, seven had integrase strand transfer inhibitor (INSTI) resistance. "
3.	Weight Gain 01/01/2023 - "Many studies have reported weight gain in ART-naive people living with HIV (PWH) initiating an integrase strand-transfer inhibitor-based regimen. " 12/15/2022 - "Several recent studies have linked integrase strand transfer inhibitors (INSTI) with increased weight gain. " 11/24/2023 - "Integrase strand transfer inhibitors (INSTIs) are associated with excessive weight gain among a subset of persons with HIV (PWH), due to unclear mechanisms. " 09/20/2023 - "People living with HIV (PLWH) starting or switching to an integrase strand transfer inhibitor-based regimen are more likely to experience weight gain than other classes of antiretroviral regimens. " 06/20/2023 - "Integrase strand-transfer inhibitors (INSTIs) are associated with weight gain in women living with HIV (WLH). "
4.	Neoplasms (Cancer) 01/01/2016 - "In the present study we developed a new cancer specific binary expression system activated by the Integrase (Int) of the lambdoid phage HK022. " 06/29/2010 - "To study whether hydrodynamic delivery alone, or in conjunction with delivery of phiC31 integrase for long-term transgene expression, could facilitate tumor formation, we used a transgenic mouse model in which sustained induction of the human C-MYC oncogene in the liver was followed by hydrodynamic injection. " 12/01/2022 - "CD34 was positive in a few tumor cells, and integrase interactor 1 (INI1) retained nuclear expression. " 09/02/2022 - "The age of disease onset was 30.5 (12.0, 75.0) months, the tumor diameter was (80±29) mm, and no integrase interactor 1 (INI-1) expression was detected by immunohistochemistry. " 03/01/2022 - "Integrase Strand Transfer Inhibitor Use and Cancer Incidence in a Large Cohort Setting."
5.	Inflammation (Inflammations) 05/01/2020 - ": The present study investigated the potential protective effects of schisandrin B (Sch B) on the Wingless/Integrase-1 (Wnt) signaling pathway in attenuating inflammation and oxidative stress in ICR mice.Methods" 01/01/2017 - "Impact of CCR5, integrase and protease inhibitors on human endothelial cell function, stress, inflammation and senescence." 01/01/2023 - "Integrase strand transfer inhibitors (INSTIs), therapy of choice in the treatment of naive HIV-patients, are able to reverse the impact of HIV infection on systemic inflammation, gut permeability, and gut bacterial diversity/richness. " 05/01/2017 - "The Wingless/integrase-1 (Wnt) family of protein ligands and their functional antagonists, secreted frizzled-related proteins (sFRPs), regulate various biological processes ranging from embryonic development to immunity and inflammation. " 01/01/2020 - "The aim of this work was to explore the impact of elvitegravir, dolutegravir, raltegravir (integrase strand transfer inhibitors, INSTIs) and atazanavir (protease inhibitor, PI) on several soluble markers of immune activation and inflammation during the first year of effective combination anti-retroviral therapy (cART). "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Protease Inhibitors (Protease Inhibitor)
3.	bictegravir
4.	Integrases
5.	Peptide Hydrolases (Proteases)
6.	Proteins (Proteins, Gene)
7.	Antiviral Agents (Antivirals)
8.	schizandrin B
9.	Reverse Transcriptase Inhibitors
10.	imidazole mustard (BIC)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Liver Transplantation
4.	Art Therapy
5.	Ambulatory Care (Outpatient Care)