Interleukin-15 (Interleukin 15)

12/15/1998 - "Overall, the data suggest that the interaction of NK cells with tumor-specific alphabeta or gammadelta T lymphocytes is necessary for successful therapy, while B cells appear to suppress the antitumor effects of CY + IL-15 therapy."
07/01/2011 - "In vivo IL-15 transfected CD4(+) T cells were more effective in suppressing tumor growth than control retroviral vector transfected ones. "
02/15/2015 - "Furthermore, CD8+ T effector cell-mediated ADCC was enhanced in the presence of IL-15 and strongly improved after glycosylation of anti-EGFR mAb indicating the potential of glycoengineered therapeutic mAb as efficient biologicals in cancer therapy."
06/01/2014 - "The endogenous availability of IL-15 was effective in inducing the dentritic cells maturation and IL-15 also shows tumor-specific antitumor activities. "
06/15/2012 - "We demonstrated greater CD8 T cell-mediated therapeutic efficacy using a combination regimen of murine IL-15 administered with an agonistic anti-CD40 Ab (FGK4.5) that led to increased IL-15Rα expression on dendritic cells (DCs), as well as other cell types, in a syngeneic established TRAMP-C2 tumor model. "

04/01/2005 - "Furthermore, we showed that IL-15 is important for CpG oligodeoxynucleotide (ODN)-induced innate protection against genital HSV-2 infection. "
04/01/2005 - "For this study, we examined whether IL-15 has any direct antiviral activity, independent of NK/NKT cells, in innate protection against HSV-2 infection. "
03/01/2015 - "Adoptive transfer of IL-15 activated CXCR3(+) innate CD8(+) T cells conferred increased protection against Listeria monocytogenes infection in susceptible IFN-γ(-/-) mice compared with similarly activated CXCR3(-) subset. "
01/01/2009 - "Interleukin-15 and NK1.1+ cells provide innate protection against acute Salmonella enterica serovar Typhimurium infection in the gut and in systemic tissues."
09/01/2007 - "Adaptive immune responses fail to provide protection against genital HSV-2 infection in the absence of IL-15."

12/15/2014 - "This study reveals that whereas IL-15 effects on NK cells are important, it also has effects on other immune cells that contribute to metastasis. "
01/01/2002 - "In the adoptive cellular immunotherapy study, the IL-15-NK plus IL-15 plus rhPRL group showed significantly lower numbers of lung metastases and longer survival than the IL-15-NK plus IL-15 group; the mean survival interval was prolonged from 31.5 to 53.7 days. "
12/15/1998 - "In the present study, we investigated the immune response against the 76-9 experimental lung metastases after CY + IL-15 therapy. "
12/15/2014 - "The lack of IL-15 in IL-15(-/-) mice, and possibly the Th2-polarized CD4 T cells, was found to promote the formation of M2 macrophages that are thought to contribute to metastasis formation. "
12/15/2014 - "When NK cells were depleted from control C57BL/6 mice, these mice did not form as many metastatic foci as IL-15(-/-) mice, suggesting that other cell types may be contributing to metastasis in the absence of IL-15. "

06/20/2006 - "IL-15 targeting is effective in treating experimental and clinical rheumatoid arthritis (RA). "
10/01/2012 - "Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study."
05/01/2007 - "Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis."
09/01/2005 - "Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study."
11/01/2015 - "Therapeutic potential of IL-15 in rheumatoid arthritis."

05/01/2014 - "Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults."
06/01/2014 - "These results indicate the ability of IL-15, a cytokine produced by renal epithelial during inflammation, to provoke CD28(-) memory CD8 T cell proliferation and to confer memory CD8 T cell resistance to CTLA-4Ig-mediated costimulation blockade. "
05/01/2014 - "IL-15 is involved in regulating host defense and inflammation. "
02/04/2014 - "Finally, IL-15 expression in blood and LECs of peripheral lymphoid organs significantly increased in LPS-induced inflammation. "
06/01/2013 - "This suggests that IL-15 may mediate the inflammation responsible for LPS-induced resorption. "