Platelet Endothelial Cell Adhesion Molecule-1

A cell adhesion molecule, composed of a series of Ig-like domains, and expressed on virtually all MONOCYTES; PLATELETS; and GRANULOCYTES. PECAM-1 is highly expressed on endothelial cells and concentrated at the junctions between them. It is essential for TRANSENDOTHELIAL MIGRATION of leukocytes and removal of apoptotic cells by PHAGOCYTES.

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Networked: 575 relevant articles (12 outcomes, 67 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Newman, Peter J: 10 articles (11/2018 - 07/2003)
2.	Jackson, Denise E: 9 articles (01/2022 - 06/2002)
3.	Newman, Debra K: 9 articles (11/2018 - 07/2003)
4.	Albelda, Steven M: 6 articles (08/2011 - 03/2002)
5.	Sheibani, Nader: 6 articles (02/2011 - 02/2004)
6.	Muzykantov, Vladimir R: 5 articles (07/2015 - 03/2002)
7.	Hwang, In Koo: 5 articles (03/2010 - 06/2005)
8.	Yoo, Ki-Yeon: 5 articles (03/2010 - 06/2005)
9.	Wong, Mae-Xhum: 5 articles (01/2005 - 06/2002)
10.	Eshaq, Randa S: 4 articles (10/2021 - 01/2019)

Related Diseases

1.	Inflammation (Inflammations) 02/15/1996 - "These studies demonstrate that PECAM-1 could play an important role in the extravasation of NK cells into tissues for constitutive surveillance and into sites of inflammation." 01/01/2022 - "Interestingly, endothelial cell neuroimmune activity was differentially associated with levels of PECAM-1 expression, suggesting that subsets of cerebrovascular endothelial cells were transitioning to resolution of inflammation following the 20-day exposure. " 01/01/2021 - "Aortic VECs exposed to pulsatile WSS similar to that in vivo at the tip of aortic side of the valve leaflet upregulated pro-EndMT (ACTA2, Snail, TGFβ1) and inflammation (ICAM-1, VCAM-1) genes, whereas expression of endothelial markers like PECAM-1 was decreased. " 01/01/2020 - "Furthermore, we demonstrated that compared with pulsatile shear stress (PS), oscillatory shear stress decreased the expression of Cdh1 and the ubiquitination of PECAM-1, therefore stabilizing PECAM-1 to promote inflammation in ECs. " 01/01/2016 - "Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes during inflammation and in the maintenance of vascular endothelial integrity. "
2.	Multiple Sclerosis 06/04/2022 - "PECAM-1 Is Down-Regulated in γδT Cells during Remission, but Up-Regulated in Relapse of Multiple Sclerosis." 05/01/2000 - "Association study of a new polymorphism in the PECAM-1 gene in multiple sclerosis." 12/01/2006 - "It has been shown that serum and CSF levels of PECAM-1 and sPECAM-1 are increased in patients in active stages of multiple sclerosis. " 02/01/2006 - "PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions." 08/15/2002 - "Polymorphic microsatellite markers in the genes for gelatinase B, PECAM-1 and MCP-3 have previously been analysed in Swedish and Sardinian individuals to test for association with multiple sclerosis (MS). "
3.	Thrombosis (Thrombus) 07/01/2000 - "These studies are consistent with a role for PECAM-1 in modulating thrombosis in the vasculature, which is potentially mediated by endothelial cell PECAM-1 expression." 07/01/2000 - "Antibody inhibition studies suggest that PECAM-1 plays a role in modulating thrombosis; however, recent in vitro aggregation studies performed on platelets harvested from PECAM-1-deficient mice revealed no abnormalities. " 08/26/2023 - "Previously, we introduced a new parameter called the PECAM-1/thrombus ratio, which indicates the proportion of PECAM-1 in the thrombus and provides a precise description of human platelet activity (in vitro). " 09/04/2021 - "Because PECAM-1 is an antithrombotic molecule, the higher the PECAM-1/thrombus ratio, the less activated the platelets. " 01/01/2020 - "The ratio of the area of PECAM-1 to the area of the thrombus was used as a marker to assess the activity of PS-negative platelets. "
4.	Atherosclerosis 11/01/2008 - "The aim of this study was to determine the in vivo role of PECAM-1 in atherosclerosis. " 05/01/2003 - "A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies." 04/01/2021 - "Here we tested the hypothesis that activation of Syk played an important in LSS-induced atherosclerosis via PECAM-1 signaling pathway. " 07/01/2016 - "The platelet endothelial cell adhesion molecule 1 (PECAM-1) plays an important role in many inflammatory processes, including the development of atherosclerosis. " 01/01/2015 - "Low shear stress (LSS) plays a critical role in the site predilection of atherosclerosis through activation of cellular mechanosensors, such as platelet endothelial cell adhesion molecule 1 (PECAM-1). "
5.	Pancreatitis 08/01/2003 - "To study the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in rats with acute edematous pancreatitis (AEP). " 05/01/2004 - "Effects of TCMP-1 on the changes of platelet endothelial cell adhesion molecule-1 expression in acute edematous pancreatitis." 08/01/2003 - "Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis." 05/01/2004 - "We investigated the effects of a compound of traditional Chinese medicine pancreatitis-1 (TCMP-1) on the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in acute edematous pancreatitis (AEP). " 05/01/2004 - "Numerous experimental and clinical studies have shown that platelet endothelial cell adhesion molecule-1 (PECAM-1) is pivotal to leukocyte recruitment, which results in microcirculatory injury during inflammation, but its role in acute pancreatitis is poorly understood. "

Related Drugs and Biologics

1.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2.	Proteins (Proteins, Gene)
3.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
4.	Monoclonal Antibodies
5.	Plasminogen Activators (Plasminogen Activator)
6.	Cell Adhesion Molecule-1
7.	Glucose (Dextrose)
8.	Peroxidase (Myeloperoxidase)
9.	Lipopolysaccharides
10.	Interleukin-1 (Interleukin 1)

Related Therapies and Procedures

1.	Catheters
2.	Compression Stockings
3.	Lasers (Laser)
4.	Thrombolytic Therapy
5.	Transplantation