CD31 Antigens

Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.

Also Known As:

Networked: 405 relevant articles (7 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jackson, Denise E: 8 articles (06/2013 - 06/2002)
2.	Newman, Peter J: 7 articles (01/2012 - 12/2003)
3.	Newman, Debra K: 6 articles (01/2012 - 12/2003)
4.	Sheibani, Nader: 6 articles (02/2011 - 02/2004)
5.	Muzykantov, Vladimir R: 5 articles (07/2015 - 03/2002)
6.	Albelda, Steven M: 5 articles (08/2011 - 03/2002)
7.	Yoo, Ki-Yeon: 5 articles (03/2010 - 06/2005)
8.	Hwang, In Koo: 5 articles (03/2010 - 06/2005)
9.	Wong, Mae-Xhum: 5 articles (01/2005 - 06/2002)
10.	Gibbins, Jonathan M: 4 articles (09/2014 - 07/2004)

Related Diseases

1.	Inflammation 08/01/2008 - "In this study, we used PECAM-1(-/-) mice and relevant cells derived from them to assess the role of PECAM-1 in an experimental model of acute colonic inflammation with a predominant innate immune response, i.e., 2,4,6-trinitrobenzine sulfonic acid (TNBS). " 09/15/1996 - "This study, using a new monoclonal antibody (mAb) TLD-3A12, describes the distribution of PECAM-1 (CD31), an Ig supergene family adhesion molecule thought to be important in leukocyte transmigration during inflammation, in rat lymphoid organs and spinal cord. " 02/15/1996 - "These studies demonstrate that PECAM-1 could play an important role in the extravasation of NK cells into tissues for constitutive surveillance and into sites of inflammation." 10/01/2015 - "It suggests that reduction/lack in PECAM-1 may lead to greater and prolonged inflammation which can be prevented by anti-TNFα." 10/01/2015 - "Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is known to play an important role in hepatic inflammation. "
2.	Thrombosis (Thrombus) 07/01/2000 - "These studies are consistent with a role for PECAM-1 in modulating thrombosis in the vasculature, which is potentially mediated by endothelial cell PECAM-1 expression." 07/01/2000 - "Antibody inhibition studies suggest that PECAM-1 plays a role in modulating thrombosis; however, recent in vitro aggregation studies performed on platelets harvested from PECAM-1-deficient mice revealed no abnormalities. " 09/01/2014 - "These findings expand our understanding of how PECAM-1 regulates nonimmunoreceptor signaling pathways and helps to explains how PECAM-1 regulates thrombosis." 11/07/2013 - "Platelet endothelial cell adhesion molecule 1 (PECAM-1) is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution. " 11/07/2013 - "Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution."
3.	Atherosclerosis 11/01/2008 - "The aim of this study was to determine the in vivo role of PECAM-1 in atherosclerosis. " 05/01/2003 - "A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies." 01/01/2015 - "Low shear stress (LSS) plays a critical role in the site predilection of atherosclerosis through activation of cellular mechanosensors, such as platelet endothelial cell adhesion molecule 1 (PECAM-1). " 01/01/2015 - "CD31, also called platelet endothelial cell adhesion molecule-1 (PECAM-1), is thought to play a role in the pathological mechanisms of atherosclerosis. " 04/01/2013 - "Because PECAM-1 has been demonstrated to form a mechanosensory complex that can modulate inflammatory responses in murine arterial endothelial cells, we hypothesized that PECAM-1 contributes to atherogenesis in a shear-dependent and site-specific manner. "
4.	Pancreatitis 08/01/2003 - "To study the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microcirculation in rats with acute edematous pancreatitis (AEP). " 05/01/2004 - "Effects of TCMP-1 on the changes of platelet endothelial cell adhesion molecule-1 expression in acute edematous pancreatitis." 08/01/2003 - "Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis." 05/01/2004 - "We investigated the effects of a compound of traditional Chinese medicine pancreatitis-1 (TCMP-1) on the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in acute edematous pancreatitis (AEP). " 05/01/2004 - "Numerous experimental and clinical studies have shown that platelet endothelial cell adhesion molecule-1 (PECAM-1) is pivotal to leukocyte recruitment, which results in microcirculatory injury during inflammation, but its role in acute pancreatitis is poorly understood. "
5.	Multiple Sclerosis 05/01/2000 - "Association study of a new polymorphism in the PECAM-1 gene in multiple sclerosis." 12/01/2006 - "It has been shown that serum and CSF levels of PECAM-1 and sPECAM-1 are increased in patients in active stages of multiple sclerosis. " 02/01/2006 - "PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions." 08/15/2002 - "Polymorphic microsatellite markers in the genes for gelatinase B, PECAM-1 and MCP-3 have previously been analysed in Swedish and Sardinian individuals to test for association with multiple sclerosis (MS). " 08/15/2002 - "Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis."

Related Drugs and Biologics

1.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2.	Plasminogen Activators (Plasminogen Activator)
3.	Monoclonal Antibodies
4.	Interleukin-1 (Interleukin 1)
5.	Apolipoproteins E (ApoE)
6.	lexipafant
7.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	E-Selectin
10.	P-Selectin

Related Therapies and Procedures

1.	Catheters
2.	Compression Stockings
3.	Transplants (Transplant)
4.	Thrombolytic Therapy
5.	Homologous Transplantation (Allograft)