Macrophage Inflammatory Proteins

Heparin-binding proteins that exhibit a number of inflammatory and immunoregulatory activities. Originally identified as secretory products of MACROPHAGES, these chemokines are produced by a variety of cell types including NEUTROPHILS; FIBROBLASTS; and EPITHELIAL CELLS. They likely play a significant role in respiratory tract defenses.

Also Known As:

Networked: 145 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Terpos, Evangelos: 3 articles (12/2005 - 10/2003)
2.	Nguyen, Mia T: 2 articles (01/2015 - 01/2014)
3.	Thames, April D: 2 articles (01/2015 - 01/2014)
4.	Du, Angela M: 2 articles (01/2015 - 01/2014)
5.	Nahcivan, Melissa: 2 articles (01/2015 - 01/2014)
6.	Chiappelli, Francesco: 2 articles (01/2015 - 01/2014)
7.	Sama, Nateli: 2 articles (01/2015 - 01/2014)
8.	Jan, Allison L: 2 articles (01/2015 - 01/2014)
9.	Guo, Liang: 2 articles (12/2010 - 01/2009)
10.	Kaneko, Shuichi: 2 articles (06/2007 - 04/2006)

Related Diseases

1.	Infection 01/01/2014 - "During Listeria monocytogenes infection, we observed markedly reduced secretion of macrophage inflammatory protein-1 alpha (MIP-1α) in livers of GrzM-deficient mice, which resulted in significantly impaired NK cell recruitment. " 02/01/2003 - "Macrophage inflammatory protein-1 alpha (MIP-1 alpha) has an important role in the development of inflammatory responses during infection by regulating leukocyte trafficking and function. " 12/01/2000 - "The role of macrophage inflammatory protein-1 alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection." 05/01/1999 - "To investigate the pertinent sources of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in vivo, we used MIP-1 alpha-deficient (MIP-1 alpha-/-) mice as donors and as recipients in adoptive transfer experiments after a lethal infection with Listeria monocytogenes (LM). " 01/01/1993 - "Macrophage inflammatory protein-1 (MIP-1), a novel cytokine composed of alpha/beta subunits, is released from macrophages during infection. "
2.	Neoplasms (Cancer) 02/01/2008 - "OBJECTIVE To explore the effects of human macrophage inflammatory protein-1 beta (hMIP-1beta) modification on the in vivo tumorigenicity and vaccine efficacy of tumor cells. " 03/01/1998 - "We investigated expression of macrophage inflammatory protein-1 (MIP-1) alpha and beta in human astrocytoma cell lines and surgical specimens of astrocytic tumors. " 06/01/1998 - "Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1 alpha (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010." 01/01/2015 - "Macrophage inflammatory protein-1 alpha (MIP-1α) is a member of a family of chemoattractant cytokines that can induce the migration of monocytes, which in turn can play a role in fighting tumors. " 05/01/1997 - "Tumor necrosis factor and macrophage inflammatory protein-1 alpha and -1 beta were immediately synthesized, in the absence of T lymphocytes, at the local tumor site in the lung. "
3.	Inflammation 01/01/1995 - "Since macrophage inflammatory protein-1 alpha (MIP-1 alpha) has previously been found to be chemotactic for eosinophils, in vitro, we postulated that MIP-1 alpha was involved in the airway inflammation and more specifically in eosinophil recruitment into the airway. " 03/01/1994 - "The production of macrophage inflammatory protein-1 alpha (MIP-1 alpha), a chemotactic cytokine which has an important role in vivo for the recruitment of leukocytes to a site of inflammation, was also significantly inhibited during peak production on Days 4 and 5 of the MLR assay. " 01/01/2014 - "The macrophage inflammatory proteins MIP1α (CCL3) and MIP2α (CXCL2) in implant-associated osteomyelitis: linking inflammation to bone degradation." 08/01/2004 - "The expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in granulomatous inflammation of lymph nodes was determined in 1-day-old piglets inoculated intranasally with porcine circovirus 2 (PCV2). " 08/01/2004 - "Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 in porcine circovirus 2-induced granulomatous inflammation."
4.	Wounds and Injuries (Trauma) 03/01/1990 - "This study examines the appearance of messenger RNA (mRNA) for cachectin/tumor necrosis factor (TNF), IL 1, and macrophage inflammatory proteins 1 and 2 (MIP-1 and MIP-2), as well as the mature peptides, in a model of wound healing using wound chambers. " 03/01/2012 - "Using quantitative real time polymerase chain reaction (RT-qPCR), the expression of interleukins (IL-1β and IL-6), tumor necrosis factor (TNF)-α, macrophage inflammatory proteins (MIP)-2α (also called Cxcl2) and MIP-1αR (also called Ccr1), matrix metalloproteases (MMP-9 and MMP-2), laminin γ2 monomer (Lamc2) and keratin (K)1 was determined up to 21 days after HD challenge in order to allow enough time for wound repair to begin. " 10/01/2008 - "Talactoferrin also enhanced the production of key repair inflammatory mediators IL-8, IL-6, macrophage inflammatory protein-1 alpha, and tumor necrosis factor alpha in d 3 wounds, and IL-8, IL-6, and monocyte chemotactic protein-1 in cultured dermal fibroblasts. "
5.	Chronic Hepatitis C 06/18/2007 - "The current study was designed to investigate the contribution of chemokines to the pathogenesis of chronic hepatitis C and hepatocellular carcinoma (HCC) by measuring the production of IL-8, monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 alpha (MIP-1alpha). " 06/15/2002 - "The surface expression of CC chemokine receptor (CCR) 1, CCR4, and CCR5 on peripheral blood T lymphocytes and their responsiveness to the chemokines macrophage inflammatory proteins (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation, normally T cell-expressed and secreted) was analyzed in patients with chronic hepatitis C and hepatitis B infection and compared with healthy subjects. "

Related Drugs and Biologics

1.	Chemokine CCL5
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	CC Chemokines
4.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
5.	Interleukin-8 (Interleukin 8)
6.	Chemokines
7.	Messenger RNA (mRNA)
8.	Interleukin-10 (Interleukin 10)
9.	Interferon-gamma (Interferon, gamma)
10.	Transforming Growth Factor beta (TGF-beta)

Related Therapies and Procedures

1.	Resuscitation
2.	Continuous Ambulatory Peritoneal Dialysis (CAPD)