Arrestin

A 48-Kd protein of the outer segment of the retinal rods and a component of the phototransduction cascade. Arrestin quenches G-protein activation by binding to phosphorylated photolyzed rhodopsin. Arrestin causes experimental autoimmune uveitis when injected into laboratory animals.

Also Known As:

Networked: 559 relevant articles (21 outcomes, 59 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bagnato, Anna: 9 articles (01/2019 - 03/2014)
2.	Rosanò, Laura: 9 articles (01/2019 - 03/2014)
3.	Luttrell, Louis M: 7 articles (01/2017 - 08/2006)
4.	Lefkowitz, Robert J: 6 articles (12/2021 - 03/2011)
5.	Rockman, Howard A: 5 articles (12/2021 - 10/2011)
6.	Chung, Jun: 5 articles (08/2020 - 01/2014)
7.	Soung, Young Hwa: 5 articles (08/2020 - 01/2014)
8.	Lee, Richard T: 5 articles (01/2020 - 06/2010)
9.	Urs, Nikhil M: 4 articles (01/2022 - 01/2019)
10.	Wess, Jürgen: 4 articles (01/2021 - 05/2010)

Related Diseases

1.	Dyskinesias (Dyskinesia) 01/01/2022 - "Studies in primates and rodents have shown that shifting the balance of dopamine receptor signaling toward the arrestin pathway can be beneficial for inducing normal movement, while reducing motor side effects such as dyskinesias, and can be efficacious at enhancing cognitive function compared to balanced agonists. " 03/12/2020 - "Studies have shown that shifting the balance of dopamine receptor signaling toward the arrestin pathway can be beneficial for inducing normal movement, while reducing dyskinesias. " 01/01/2022 - "Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via β-arrestin signaling." 01/01/2023 - "Previous studies have suggested that therapeutic effects can be realized by targeting the β-arrestin signaling pathway of dopamine receptors, while overactivation of the G protein-dependent pathways leads to side effects, such as dyskinesias. " 01/01/2017 - "Furthermore the discovery of this novel ACh-dopamine interaction and the participation of β-arrestin in regulation of cholinergic interneurons is likely important for other basal ganglia disorders characterized by perturbation of ACh-dopamine balance, including Parkinson and Huntington diseases, l-DOPA-induced dyskinesia and schizophrenia."
2.	Asthma (Bronchial Asthma) 12/06/2022 - "However, the therapeutic efficacy of β-agonists is limited by agonist-induced β2AR desensitization and noncanonical β2AR signaling involving β-arrestin that is shown to promote asthma pathophysiology. " 12/01/2018 - "Thus, β-arrestin-biased PAR2 antagonists represent novel therapeutic targets for treating aeroallergen-induced asthma." 06/01/2014 - "This review explores the evidence supporting the hypothesis that β-arrestin-dependent signaling downstream of β2AR and PAR2 is detrimental in asthma and examines the therapeutic opportunities for selectively targeting this pathway. " 06/01/2014 - "Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma." 01/01/2015 - "As β-arrestins are known to modulate β2AR function, our analysis of βAR subtype expression in β-arrestin knockout mice airways sets a reference point for future studies exploiting these knockout mice in various disease models including asthma. "
3.	Pain (Aches) 06/01/2019 - "Arrestin-g pain." 01/01/2023 - "C781, a β-Arrestin Biased Antagonist at Protease-Activated Receptor-2 (PAR2), Displays in vivo Efficacy Against Protease-Induced Pain in Mice." 01/01/2017 - "Circumventing arrestin-dependent GPCR desensitization may alleviate the problem of tachyphylaxis to drugs that target GPCRs, and find application in the management of chronic pain, asthma, and psychiatric illness. " 01/01/2022 - "Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors." 01/01/2020 - "Biased ligands to μOR that induce G protein signaling without inducing β-arrestin signaling can alleviate pain while reducing side effects. "
4.	Photophobia (Light Sensitivity) 01/01/2010 - "Arrestin reduction in the mutant modestly increased the light sensitivity and decreased the photoreceptor dynamic range. " 01/01/2014 - "The results showed that even in this extremely demanding situation of rods that have no ability to phosphorylate rhodopsin, enhanced arrestin improved rod morphology, light sensitivity, survival, and accelerated photoresponse recovery. " 01/01/2014 - "In vivo this approach was so far tested only in rod photoreceptors deficient in rhodopsin phosphorylation, where enhanced arrestin improved the morphology and light sensitivity of rods, prolonged their survival, and accelerated photoresponse recovery. " 11/06/2023 - "Animals with enhanced dim-light sensitivity are at higher risk of light-induced retinal degeneration when exposed to bright light conditions.1,2,3,4 This trade-off is mediated by the rod photoreceptor sensory protein, rhodopsin (RHO), and its toxic vitamin A chromophore by-product, all-trans retinal.5,6,7,8 Rod arrestin (Arr-1) binds to RHO and promotes sequestration of excess all-trans retinal,9,10 which has recently been suggested as a protective mechanism against photoreceptor cell death.2,11 We investigated Arr-1 evolution in animals at high risk of retinal damage due to periodic bright-light exposure of rod-dominated retinas. "
5.	Osteoporosis 01/01/2013 - "Exploitation of β-arrestin-biased agonism may offer therapeutic benefit for the treatment of metabolic bone diseases such as osteoporosis with an improved side effect profile." 06/01/2011 - "Exploitation of β-arrestin biased agonism may offer therapeutic benefit for the treatment of metabolic bone diseases such as osteoporosis." 09/01/2011 - "Recent work with the type I parathyroid hormone receptor (PTH(1) R) suggests that biased ligands that selectively activate G-protein-independent arrestin-mediated signalling pathways may hold promise in the treatment of osteoporosis. "

Related Drugs and Biologics

1.	Ligands
2.	GTP-Binding Proteins (G-Protein)
3.	Dopamine Receptors (Dopamine Receptor)
4.	Opioid Analgesics (Opioids)
5.	Rhodopsin (Visual Purple)
6.	Antigens
7.	Peptides (Polypeptides)
8.	Opioid Receptors (Opioid Receptor)
9.	beta-Arrestin 1
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Analgesia
2.	Pain Management
3.	Therapeutics
4.	Oral Administration
5.	Drug Therapy (Chemotherapy)