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Cytochrome P-450 CYP2E1 (CYP2E1)

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An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include alcohol; NITROSAMINES; BENZENE; URETHANE; and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.

Also Known As:

CYP2E1; CYP 2E1; CYP IIE1; CYPIIE1; Cytochrome P-450 (ALC); Cytochrome P-450 IIE1; Cytochrome P-450-J; Cytochrome P450 2E1; N-Nitrosodimethylamine Demethylase; 4 Nitrophenol 2 Hydroxylase; Cytochrome P 450 CYP2E1; Cytochrome P 450 IIE1; Cytochrome P 450 J; Dimethylnitrosamine N Demethylase; N Nitrosodimethylamine Demethylase; 4-Nitrophenol-2-Hydroxylase; Dimethylnitrosamine N-Demethylase

Networked: 870 relevant articles (16 outcomes, 194 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Cederbaum, Arthur I: 21 articles (01/2014 - 04/2002)
2.	Lee, Myung Gull: 9 articles (08/2008 - 06/2002)
3.	Wang, Xiaodong: 8 articles (01/2014 - 08/2005)
4.	French, Samuel W: 8 articles (01/2013 - 07/2002)
5.	Wu, Defeng: 7 articles (01/2014 - 02/2008)
6.	Albano, Emanuele: 7 articles (01/2014 - 01/2002)
7.	Gonzalez, Frank J: 7 articles (12/2013 - 01/2005)
8.	Ingelman-Sundberg, Magnus: 7 articles (11/2010 - 07/2002)
9.	Lee, Inchul: 7 articles (07/2008 - 01/2002)
10.	Abdelmegeed, Mohamed A: 6 articles (01/2015 - 01/2009)

Related Diseases

1.	Obesity 01/01/2012 - "In this report, we review our studies on whether induction of CYP2E1 can potentiate liver injury in obesity. " 03/28/2015 - "The top ten up- or down-regulated genes include Acsm3, mt-Nd6, Fam13a, Cyp2e1, Rgs1 and Gpnmb, whose roles in the deterioration of obesity-associated adipose tissue are poorly understood. " 11/15/2014 - "We found a total of 15 genes that were consistently upregulated with obesity (MIS18A, CTRB1, FAM151B, FOLR2, PXMP4, OAS1B, SREBF2, KLRA17, SLC25A44, SNX10, SLFN3, MEF2BNB, IRF7, RAD23A, LGALS3BP) and five genes that were consistently downregulated with obesity (C2, GOLGA7, RIN3, PCP4, CYP2E1). " 01/01/2014 - "The enhanced levels of CYP2E1 and increased oxidative stress in obesity play a significant role in this process. " 11/01/2011 - "Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity."
2.	Insulin Resistance 06/01/2014 - "CYP2E1 knockout mice are protected against high fat diet-induced insulin resistance and obesity; however the molecular mechanisms are still unclear. " 10/01/2012 - "These data suggest that CYP2E1 is critically important in NASH development by promoting oxidative/nitrosative stress, protein modifications, inflammation, and insulin resistance." 03/01/2012 - "Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance." 10/01/2005 - "In conclusion, forced overfeeding with a high-fat diet in mice induces obesity, insulin resistance, and SH in the absence of TNF signaling or Cyp2e1 induction." 03/01/2012 - "Taken together, these data demonstrate that the CYP2E1 deletion protects mice against high-fat diet-induced insulin resistance with improved glucose homeostasis in vivo."
3.	Hyperglycemia 10/01/2013 - "The study demonstrates the role of CYP2E1 mediated oxidative stress in aggravating hyperglycemic insult and suggests that CYP2E1 may be a vital component of hyperglycemia mediated oxidative injury in liver." 08/01/2011 - "Thus, changes in regulation of CYP2E1 are associated with the injurious effects of hyperglycemia in liver." 08/01/2011 - "Some of the hepatic abnormalities associated with hyperglycemia-mediated induction of CYP2E1 include increased oxidative stress, changes in mitochondrial structure and function, apoptosis, nitrosative stress, and increased ketone body accumulation. " 08/01/2011 - "Cytochrome P450 2E1 and hyperglycemia-induced liver injury." 08/01/2002 - "This aberrant expression of metabolic genes in the knockout mice was associated with hyperglycemia, increased hepatic CYP2E1 and UCP2 expression and triglyceride levels, and reduced hepatic glutathione content. "
4.	Adenoma (Adenomas) 02/01/2007 - "Significant reduction in the incidence of adenomas and the number of adenomas/lung were observed in Cyp2e1-/- compared to Cyp2e1+/+ mice. " 01/01/2005 - "However, in normal tissue of patients with adenomas, protein levels of CYP2C8, CYP3A4 and CYP3A5, but not that of CYP2E1, were significantly lower than in biopsies obtained from disease-free controls. " 07/01/2008 - "Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study." 07/01/2008 - "CYP2E1 96-bp insertion allele was associated with an increased risk of large (> or = 5 mm) adenomas; adjusted odds ratios (95% confidence interval) of large and small adenomas for having at least one insertion allele were 1.41 (1.03-1.94) and 0.94 (0.71-1.25), respectively. " 02/01/2007 - "In the Harderian gland, the incidences of hyperplasia and adenomas were significantly lower in Cyp2e1-/- compared to Cyp2e+/+ mice at the 10 mg/kg dose, with no significant differences observed at the high or low doses. "
5.	Poisoning 02/01/2015 - "The carriers of at least one minor allele in the CYP2E1 gene had less severe clinical symptoms and better short-term outcome after acute poisoning. " 07/01/2015 - "Response to 'CYP2E1 polymorphism and better outcome after methanol poisoning'." 07/01/2015 - "CYP2E1 polymorphism and better outcome after methanol poisoning." 08/01/2015 - "Mutations at CYP2E1 RsaI/PstI can enhance the expression of CYP2E1 and this suggests individuals with the mutated gene have increased susceptibility to chronic benzene poisoning." 02/01/2015 - "Variants within the CYP2E1 gene are likely not significant genetic determinants of acute methanol poisoning (if survivors are analysed), but they may influence the severity of methanol poisoning and its visual/central nervous system (CNS) outcome. "

Related Drugs and Biologics

1.	Methanol (Carbinol)
2.	Cytochrome P-450 CYP1A1 (CYP1A1)
3.	Ethanol (Ethyl Alcohol)
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Cytochrome P-450 CYP1A2 (CYP1A2)
6.	Acetaminophen (Paracetamol)
7.	Insulin (Novolin)
8.	Carcinogens
9.	Chlorzoxazone
10.	S-mephenytoin N-demethylase (CYP2B6)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Drug Therapy (Chemotherapy)
3.	Ketogenic Diet
4.	Bariatric Surgery
5.	Heart Transplantation (Grafting, Heart)