Cytochrome P-450 CYP1A1 (CYP1A1)

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

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Networked: 1575 relevant articles (14 outcomes, 362 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	El-Kadi, Ayman O S: 21 articles (04/2014 - 09/2004)
2.	Nebert, Daniel W: 14 articles (09/2014 - 11/2002)
3.	Moorthy, Bhagavatula: 13 articles (11/2015 - 03/2002)
4.	Jiang, Weiwu: 11 articles (05/2015 - 08/2004)
5.	Taioli, Emanuela: 11 articles (01/2010 - 05/2003)
6.	Wang, Lihua: 10 articles (05/2015 - 07/2007)
7.	Couroucli, Xanthi I: 10 articles (05/2015 - 03/2002)
8.	Rannug, Agneta: 10 articles (09/2012 - 05/2003)
9.	Korashy, Hesham M: 9 articles (03/2014 - 09/2004)
10.	Uno, Shigeyuki: 9 articles (02/2014 - 11/2002)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/01/2015 - "Women with the CYP1A1 4889AG+GG genotype and earlier first full-term pregnancies had a 1.87-fold (95% CI: 1.32-2.67) increased risk of sporadic breast cancer compared to the other study participants. " 03/01/2014 - "Our results suggest that the CYP1A1 polymorphism may be useful for predicting breast cancer risk in our study population." 03/01/2014 - "The present study evaluates the existence of CYP1A1 polymorphism in a number of breast cancer samples. " 03/01/2014 - "In summary, CYP1A1 may be associated with breast cancer and its down regulation may serve as an important tool in the field of biomarker study. " 03/01/2014 - "Mutation and protein expression analysis of CYP1A1 gene-a study on female breast cancer cases from India."
2.	Hyperoxia 06/01/2006 - "The improved alveolarization in animals given RA + hyperoxia, in conjunction with the attenuation of CYP1A1 and 1A2 expression in these animals, suggests that this phenomenon may play a role in the beneficial effects of RA." 09/01/2014 - "On the other hand, Cyp1a1(-/-) mice showed higher levels after 48-72 h of hyperoxia exposure compared to WT mice. " 09/01/2014 - "Eight- to ten-week-old male WT (C57BL/6J) or Cyp1a1(-/-) mice were exposed to hyperoxia (>95% O2) or room air for 24-72 h. " 12/01/2008 - "Our results strongly suggest that hyperoxia transcriptionally activates CYP1A1 expression in human lung cell lines by AHR-dependent mechanisms, and that CYP1A1 induction is associated with decreased toxicity. " 12/01/2008 - "Here we investigated the molecular mechanisms of induction of CYP1A1 by hyperoxia in human lung cell lines. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China. " 09/01/2013 - "The aim of the present study was to investigate the association between PCB exposure levels, CYP1A1 polymorphisms and the risk of lung cancer. " 02/01/2013 - "Our results indicate that the CYP1A1*2B allele (rs4646903 and rs1048943) is associated with an increased lung cancer risk and CYP2A6*4 is associated with a decreased lung cancer risk in the study population." 02/01/2013 - "We conducted this study to determine the prevalence and role of CYP1A1, CYP2A6 and CHRNA5 polymorphisms together with tobacco smoking in the development of lung cancer in Bangladesh. " 02/01/2013 - "CYP1A1, CYP2A6 and CHRNA5 are biologically plausible genes as risk factors for lung cancer but no studies have been reported in the Bangladeshi population. "
4.	Neoplasms (Cancer) 08/01/2014 - "Our genetic study suggests that the CYP1A1 Ile462Val SNP may be a risk factor for cervical cancer among patients with a positive history of tobacco smoking and parity." 08/01/2014 - "Polymerase chain reaction-restriction fragment length polymorphism was used to study the prevalence of the CYP1A1 Ile462Val SNP in women with cervical cancer (n = 456) and controls (n = 495). " 01/01/2014 - "In this study, a meta-analysis of this literature aimed to clarify associations of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese populations. " 01/01/2014 - "Meta-analysis of association studies of CYP1A1 genetic polymorphisms with digestive tract cancer susceptibility in Chinese." 02/01/2013 - "Meta-analysis of the ten studies on cervical cancer suggested a significant association between the CYP1A1 T3801C polymorphism and cervical cancer risk (C vs. T, OR 1.38, 95 % CI 1.05-1.82, P = 0.02; CC vs. TT, OR 2.06, 95 % CI 1.15-3.70, P = 0.02; CC/CT vs. TT, OR 1.45, 95 % CI 1.03-2.02, P = 0.03; CC vs. TT/CT, OR 1.56, 95 % CI 1.20-2.03, P < 0.01). "
5.	Prostatic Neoplasms (Prostate Cancer) 05/01/2013 - "The genetic polymorphism of CYP1A1 at the site of MspI (CYP1A1 MspI) has been implicated in prostate cancer risk, but the results of individual studies remain conflicting and inconclusive. " 01/01/2009 - "We reviewed studies on CYP1A1 polymorphisms in patients with prostate cancer. " 05/01/2006 - "Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes." 05/01/2006 - "Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study." 02/01/2003 - "To study the possible relationship between CYP1A1, NAT2 genetic polymorphisms and the susceptibility of prostate cancer. "

Related Drugs and Biologics

1.	cytochrome P-450 CYP1B1 (CYP1B1)
2.	Cytochrome P-450 CYP1A1 (CYP1A1)
3.	Cytochrome P-450 CYP2E1 (CYP2E1)
4.	Messenger RNA (mRNA)
5.	Cytochrome P-450 CYP1A2 (CYP1A2)
6.	Tetrachlorodibenzodioxin (TCDD)
7.	Estrogens (Estrogen)
8.	DNA (Deoxyribonucleic Acid)
9.	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
10.	glutathione S-transferase M1

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Therapeutics
4.	Aftercare (After-Treatment)
5.	Oral Administration