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Cytochrome P-450 CYP2B1 (PROD)

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A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.

Also Known As:

PROD; BROD; 7-Benzyloxyresorufin O-Dealkylase; 7-Pentylresorufin O-Depentylase; CYP 2B1; Cytochrome P450 2B1; 7 Benzyloxyresorufin O Dealkylase; 7 Pentylresorufin O Depentylase; Benzyloxyresorufin O Dealkylase; Cytochrome P 450 CYP2B1; O-Dealkylase, Pentoxyresorufin; Pentoxyresorufin O Dealkylase; Benzyloxyresorufin O-Dealkylase; CYP2B1; Pentoxyresorufin O-Dealkylase

Networked: 198 relevant articles (5 outcomes, 21 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Cvitković, Ante: 6 articles (09/2014 - 04/2007)
2.	Salmons, Brian: 4 articles (01/2009 - 05/2002)
3.	Kolovrat, Ana: 3 articles (09/2014 - 10/2010)
4.	Waxman, David J: 3 articles (12/2010 - 09/2005)
5.	Baliga, Radhakrishna: 3 articles (12/2010 - 09/2002)
6.	Danić, Davorin: 3 articles (06/2008 - 09/2006)
7.	Pandak, Nenad: 3 articles (07/2006 - 05/2003)
8.	Wolf, Douglas C: 3 articles (01/2006 - 02/2005)
9.	Nesnow, Stephen: 3 articles (01/2006 - 02/2005)
10.	Thai, Sheau-Fung: 3 articles (01/2006 - 02/2005)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2001 - "In conclusion, a successful therapy with CPA, helped by forced expression of CYP2B1 in tumor cells (as recently proposed) will, in addition, be profoundly modified by its phosphorylation status." 06/30/1999 - "We have previously demonstrated the therapeutic effect and efficacy of implantation of cells genetically modified to express cytochrome P450 2B1 in a nude mouse tumor model. " 06/01/2000 - "These studies support a role for impaired EGFr function in PhB liver tumor promotion due to effects on existing EGFr protein and suggest that EGFr down-regulation by PhB in culture is independent of CYP2B1/2 activity but shares mechanistic components involved in its transcriptional activation by PhB." 09/01/2014 - "In the first cycle, the response rate in Brod-Posavina County was 53.2%, with 71 cancers detected at a mean age of 61.3 years. " 01/01/2008 - "It is anticipated to be used for the generation of encapsulated viral vector producing cells which, when placed inside or close to a tumor, will act as suppliers of the therapeutic CYP2B1 protein as well as of the therapeutic vector itself. "
2.	Proteinuria 09/01/2002 - "CYP2B1 inhibitors also provided significant protection against PAN induced proteinuria. " 09/01/1983 - "Subjects living in the endemic area of Posavina round Slavonski Brod have a significantly greater incidence of proteinuria (13.6%) than those living under the same conditions in the area where endemic nephropathy has not been observed (5.5%). "
3.	Shock 01/01/1999 - "Two weeks later, the preshocked group showed a significantly greater colonic spike burst response to a novel shock-prod stressor in the home cage than controls. " 12/01/1998 - "The aim of this study was to investigate differences in shock-prod induced defensive burying and vulnerability to stress gastric ulcerations in two lines of rats selectively bred for alcohol-preference (AA) and alcohol-avoidance (ANA). " 01/01/2015 - "In particular, this was evidenced by (a) all being willing to administer shocks greater than 150 volts, (b) near-universal refusal to continue after being told by the Experimenter that "you have no other choice, you must continue" (Milgram's fourth prod and the one most resembling an order), and (c) a strong correlation between the maximum level of shock that participants administered and the mean maximum shock delivered in the corresponding variant in Milgram's own research. " 06/09/2008 - "Rats are well known to bury dangerous objects; the shock-prod burying test of anxiety is based on this response. " 01/01/2007 - "The duration of burying, digging into bedding material, stretch-attend postures, and crouch/freezing were measured in a shock-prod test. "
4.	Infection 01/01/2015 - "Although indicated for the treatment of HCV genotype 1 infection, PrOD is also recommended for the treatment of HCV in patients coinfected with HIV. " 10/01/2010 - "ProD was associated with Cryptosporidium and Shigella infections. " 05/01/2003 - "We report two patients with Streptococcus suis type 1 infection, treated in "Dr Josip Bencević" General Hospital, Slavonski Brod. " 01/01/1994 - "The results obtained have place the Community of Slavonski Brod among areas with an intermediate endemicity of HBV infection." 01/01/1994 - "Prevalence of markers of hepatitis B virus infection among the general population of the municipality of Slavonski Brod."
5.	Carcinoma (Carcinomatosis) 09/01/2013 - "The aim of the study was to determine and compare specific mortality and morbidity of renal pelvis and ureter (upper urothelium) carcinoma (UUC) among Croatia as a whole, Brod-Posavina County, and Croatian endemic area. " 12/01/2013 - "During five years of the National Program performance, 28 CRC cases were detected in Brod-Posavina County, with the 3.3% rate of carcinoma detection. " 04/15/1997 - "Although PROD is more sensitive than PLAT, both parameters appear to be useful as prognostic tools for predicting early recurrence after resection of lung carcinoma. " 01/01/1979 - "[10 years of treatment of carcinoma of the lower lip at the otorhinolaryngology unit in Slavonski Brod (1965--1974)]." 04/01/1999 - "Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced-stage pancreatic carcinoma: a phase I/II study."

Related Drugs and Biologics

1.	Cytochrome P-450 CYP1A1 (CYP1A1)
2.	Cyclophosphamide (Cytoxan)
3.	Cytochromes
4.	Cytochrome P-450 CYP2B1 (PROD)
5.	Phenobarbital (Luminal)
6.	Cytochrome P-450 CYP1A2 (CYP1A2)
7.	Messenger RNA (mRNA)
8.	Cytochrome P-450 CYP2E1 (CYP2E1)
9.	Ifosfamide
10.	Glucuronosyltransferase (UDP Glucuronosyltransferase)

Related Therapies and Procedures

1.	Tissue Therapy (Cell Therapy)
2.	Oral Administration
3.	Thyroidectomy
4.	Drug Therapy (Chemotherapy)
5.	Decompression