Lactic Acid

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)

Also Known As:

Networked: 13571 relevant articles (439 outcomes, 1266 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sotgia, Federica: 28 articles (04/2014 - 12/2009)
2.	Lisanti, Michael P: 28 articles (04/2014 - 12/2009)
3.	Vigneron, Daniel B: 27 articles (09/2015 - 05/2004)
4.	Martinez-Outschoorn, Ubaldo E: 26 articles (04/2014 - 12/2009)
5.	Shapiro, Nathan I: 25 articles (01/2015 - 05/2005)
6.	Lin, Mao-Tsun: 23 articles (08/2013 - 05/2002)
7.	Kurhanewicz, John: 22 articles (10/2015 - 06/2006)
8.	Jones, Alan E: 22 articles (10/2015 - 08/2007)
9.	Howell, Anthony: 21 articles (08/2013 - 06/2010)
10.	Pestell, Richard G: 21 articles (08/2013 - 12/2009)

Related Diseases

1.	Ischemia 05/01/2003 - "Thus enhanced glycolysis resulted in increased energy efficiency under aerobic conditions but significantly enhanced lactate production with no further improvement in function during demand-induced ischemia. " 07/01/1989 - "Intrarenal lactate content increased significantly from the 5 min ischemia group to the 180 min. These results suggest that no improvement in intrarenal energy metabolism with increasing duration of renal ischemia is showed and ischemic renal injury develops progressively. " 10/01/1984 - "The drug was well tolerated by the patients, virtually did not affect the parameters of myocardial contractility, decreased the work of the heart at the expense of a significant reduction of the after-load and lowered manifestations of the ischemia of the intact myocardium (the coefficient of lactate extraction by the myocardium was found to elevate)." 11/01/1989 - "When compared with hippocampus, lactate was higher in the cerebral cortex after ischemia, and DCA was more effective in reducing those levels. " 07/01/1998 - "AR inhibition improved functional recovery in both control and diabetic hearts, coupled with a lower cytosolic redox state and greater effluent lactate concentrations during ischemia. "
2.	Acidosis 10/01/2000 - "Over the time scale of 24 hours, lactate derived from continuous dialysis circuits is efficiently cleared from the blood of most patients with multi-organ failure, but with less effect on systemic acidosis than is produced by equivalent amounts of bicarbonate." 06/01/1995 - "Response to daily training was most clearly reflected in altered lactate levels and heart rate; recovery improved with increased training which enhanced aerobic capacity and decreased metabolic acidosis." 10/01/2010 - "Comparing the two indicators of acidosis using method of "Gold standard" confirmed the higher sensitivity of lactate values above 6.7 mmol/l compared to pH < 7.00 in relation to very low values of Apgar at 5 minutes. " 01/01/2004 - "Thus, avoiding cerebral anaerobic metabolism and acidosis is beneficial to control lactate and H(+), but no compound inhibiting mediators/mediator channels showed beneficial results in conducted clinical trials, despite successful experimental studies. " 01/01/2011 - "Bicarbonate fluids led to a more rapid fall in lactate and greater improvement in base excess during CRRT, but not overall control of acidosis."
3.	Neoplasms (Cancer) 10/01/2012 - "This suggests that the rate of glycolysis is significantly greater than the PPP flux in these tumors, and that the PPP flux into the lactate pool is similar in both tumors. " 10/01/2009 - "The results of this research indicate that: 1) cardiopulmonary exercise testing with lactate threshold determination was safe and effective in the evaluation and exercise prescription phase for a group of cancer survivors and 2) a training program based on 2 higher intensity workouts per week can elicit significant changes in aerobic capacity of a diverse group of cancer survivors." 09/01/2015 - "Thus, the ability to not only measure the production of hyperpolarized (13) C lactate but also understand its compartmentalization using diffusion-weighted MR will provide unique information for improved tumor characterization. " 04/01/2013 - "Metabolite ratios of lactate to bicarbonate were calculated to provide improved metrics for characterizing tumor metabolism. " 09/01/2015 - "Other studies have shown that aggressive and highly metastatic tumors rapidly transport lactate out of cells. "
4.	Anoxia (Hypoxia) 03/01/1990 - "These data suggest that, with time, neurons in vitro adapt to severe hypoxia and that alterations in pH, lactate, and bicarbonate by themselves are probably not neurotoxic since the most acidotic cultures exhibited improved survival." 05/01/2009 - "The finding that visual stimulation leads to significantly greater visual cortex lactate responses in panic patients is not predicted by the hypoxia model. " 03/01/1996 - "Whether this would be beneficial in patients with elevated lactate levels, indicating tissue hypoxia, remains to be determined. " 01/01/2010 - "Respiratory quotient and lactate at the anaerobic threshold as well as body composition improved more in the hypoxia group. " 04/01/2013 - "To identify the presence of a hypercoagulable state in sick newborns, the behavior of SFMC with special reference to those of other coagulation tests, and the relationships with other parameters of blood coagulation as well as lactate, which is considered to be the gold standard for assessing tissue hypoxia, were studied. "
5.	Sepsis (Septicemia) 01/01/2010 - "The proportion of ED patients who had lactate tested and the number of admitted patients identified with a lactate level ≥4.0 mmol/L improved significantly after the implementation of a computer alert identifying sepsis patients with >2 SIRS criteria while mortality among admitted sepsis patients remained unchanged." 04/01/2009 - "These results demonstrate the efficacy of the abbreviated MEDS score, the MEW score and NPT venous lactate levels in predicting 28-day mortality in ED patients with sepsis. " 04/01/2009 - "To determine the efficacy of the abbreviated Mortality in Emergency Department Sepsis (MEDS) score, the Modified Early Warning (MEW) score and near-patient-test (NPT) lactate levels in predicting 28-day mortality in adult emergency department (ED) patients with sepsis. " 07/01/1995 - "Combined determinations of blood lactate concentrations and intramucosal pH or intramural PCO2 may help to predict outcome from severe sepsis." 10/01/2015 - "Early lactate clearance-guided therapy in patients with sepsis: a meta-analysis with trial sequential analysis of randomized controlled trials."

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Related Therapies and Procedures

1.	Resuscitation
2.	Oral Administration
3.	Drug Therapy (Chemotherapy)
4.	Ketogenic Diet
5.	Cardiopulmonary Resuscitation (CPR)