Citric Acid (Citrate)

A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.

Also Known As:

Networked: 3247 relevant articles (157 outcomes, 369 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Tatar, M: 15 articles (12/2013 - 01/2004)
2.	Brozmanova, M: 14 articles (12/2013 - 01/2004)
3.	Plevkova, J: 11 articles (09/2015 - 09/2004)
4.	Fiaccadori, Enrico: 11 articles (04/2015 - 12/2006)
5.	Ebihara, Satoru: 9 articles (08/2014 - 09/2003)
6.	Kurhanewicz, John: 9 articles (12/2011 - 11/2003)
7.	Mariano, Filippo: 8 articles (11/2015 - 01/2004)
8.	Morabito, Santo: 8 articles (04/2015 - 01/2012)
9.	Ray, Bimalendu: 8 articles (04/2015 - 03/2011)
10.	Oudemans-van Straaten, Heleen M: 8 articles (01/2015 - 12/2007)

Related Diseases

1.	Infection 06/01/2006 - "Both (67)Ga citrate and [(18)F]FDG are highly sensitive tracers, but their specificity for detecting infection is lower than that of in vitro labeled leukocytes, which is the radionuclide gold standard for imaging most infections. " 10/01/2015 - "In a previous study, UBiT-100 mg, (Otsuka, Spain), a commercial (13)C-urea breath test omitting citric acid pre-treatment, had a high rate of false-positive results; however, it is possible that UBiT detected low-density 'occult' infection missed by other routine reference tests. " 01/01/1994 - "Citrate therapy significantly improved the stone clearance rate in the sterile (at 6 and 12 months 65% and 74% were stone-free, respectively) and infection (71% and 86%, respectively) stone patients, and prevented residual fragment growth or reaggregation in subjects in whom clearance was not achieved. " 06/01/2010 - "Citric acid gel was found effective in the control of foot infections; especially in Wagner grades I and II, the success rate was found to be more than 94%. " 10/01/2013 - "Citric acid ointment was found effective in controlling infections. "
2.	Smear Layer 10/01/2010 - "The results of the present study clearly indicate the superior efficacy of 6% citric acid than the other tested irrigants on removing the smear layer in primary teeth root canals." 09/01/1990 - "3. Conditioning with citric acid is more effective than the application of LIV CENERA Liquid in removing the smear layer, but LIV CENERA Liquid in contrast to citric acid application, did not enlarge the dentinal tubules." 09/01/2003 - "The efficacy of various concentrations of citric acid at different pH values for the removal of the superficial smear layer from dentinal surfaces was examined through the use of scanning electron microscopy. " 09/01/2003 - "Efficacy of various concentrations of citric acid at different pH values for smear layer removal." 03/01/2013 - "According to the present study, TTC-HCL could remove debris and smear layer but citric acid and MTAD had better debris and smear layer removal efficacy and demineralization effect in comparison with TTC-HCL."
3.	Cough 12/01/1981 - "2. Efficacy of airway anaesthesia was tested by the cough response to citric acid inhalation. " 07/01/2015 - "All patients were administered a citric acid cough test and underwent a videofluoroscopic swallowing study (VFSS). " 01/01/2014 - "In the present study, we demonstrate in vitro direct functional activation of TRPA1 receptor by citric acid which is routinely used to evoke cough in preclinical and clinical studies. " 04/01/2013 - "This study investigated the inter-rater and intra-rater reliability of subjective judgements of cough in patients following inhalation of citric acid. " 10/01/2011 - "Citric acid cough challenge and laryngoscopic examination were performed at baseline and the end of the study. "
4.	Acidosis 05/01/2006 - "The present model of low-grade metabolic acidosis indicates that CP may be effective in alkalinising urine, enhancing citrate excretion and ameliorating Ca and Mg balance." 09/01/2012 - "Translational studies in patients show that NaHCO(3) ameliorates kidney injury in patients with CKD and reduced GFR, with and without metabolic acidosis; NaHCO(3) and base-inducing food types each ameliorate kidney injury in patients with reduced GFR without metabolic acidosis; and NaHCO(3) and Na(+) citrate each slow GFR decline in CKD patients with reduced GFR, with and without metabolic acidosis. " 10/01/2012 - "Acidosis induces EMT and secretion of TGF-β1 in tubular proximal cells in culture and citrate improves cellular performance and ameliorates acidosis induced EMT." 02/01/2000 - "The purpose of the present study was to examine whether metabolic acidosis affects the expression of rat renal Na(+)/citrate cotransporter. " 11/01/2015 - "An autopsy case of death due to metabolic acidosis after citric acid ingestion."
5.	Overactive Urinary Bladder (Overactive Bladder) 07/01/2009 - "The therapeutic potential of cizolirtine citrate 400mg bid in overactive bladder has been evidenced." 07/01/2009 - "Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study." 07/01/2009 - "Editorial comment on: Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study." 07/01/2009 - "Editorial comment on: Cizolirtine citrate, an effective treatment for symptomatic patients with urinary incontinence secondary to overactive bladder: a pilot dose-finding study." 01/01/2010 - "Cizolirtine citrate is safe and effective for treating urinary incontinence secondary to overactive bladder: a phase 2 proof-of-concept study."

Related Drugs and Biologics

1.	Edetic Acid (EDTA)
2.	Zinc
3.	Calcium
4.	Tetracycline (Achromycin)
5.	E 4018 (cizolirtine)
6.	Heparin (Liquaemin)
7.	Dentifrices (Dentifrice)
8.	Glucose (Dextrose)
9.	tandospirone
10.	Calcium Oxalate

Related Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy)
2.	Renal Dialysis (Hemodialysis)
3.	Catheters
4.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
5.	Renal Replacement Therapy (Therapies, Renal Replacement)