Nitroarginine (NG Nitro L Arginine)

An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)

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Networked: 409 relevant articles (6 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Guimarães, F S: 4 articles (03/2010 - 01/2000)
2.	Del Bel, E A: 4 articles (11/2005 - 01/2000)
3.	Tarrade, A: 2 articles (10/2012 - 07/2012)
4.	Morel, O: 2 articles (10/2012 - 07/2012)
5.	Tsatsaris, V: 2 articles (10/2012 - 07/2012)
6.	Gayat, E: 2 articles (10/2012 - 07/2012)
7.	Lecarpentier, E: 2 articles (10/2012 - 07/2012)
8.	Łuszczki, Jarogniew J: 2 articles (01/2011 - 07/2007)
9.	Del-Bel, E A: 2 articles (03/2010 - 03/2009)
10.	Echeverry, M B: 2 articles (03/2010 - 03/2009)

Related Diseases

1.	Anoxia (Hypoxia) 08/01/2003 - "Effect of maternal NG-nitro-l-arginine administration on fetal growth and hypoxia-induced changes in newborn rats." 12/01/1999 - "The rectal temperature of awake, unrestrained rats was measured before and after injection of LPS, with or without concomitant exposure to hypoxia, in an experimental group treated with N(omega)-nitro-L-arginine (L-NNA) for 4 consecutive days before the experiment and in a saline-treated group (control). " 03/01/1999 - "Postnatal day 6 animals were treated 0.5 hour before preconditioning hypoxia with the nonselective NOS inhibitor L-nitroarginine (2 mg/kg intraperitoneally). " 07/01/1998 - "Blockade of NO synthesis by NG-nitro-L-arginine (L-NNA, 0.3 mmol/l) administered to the ventral surface of the medulla oblongata (VLM) significantly enhanced RSNA increases induced by hypoxia and abolished the RSNA response to reoxygenation. " 09/01/1995 - "In anesthetized, paralyzed, vagotomized and artificially ventilated cats with intact carotid sinus nerves (n = 8), administration of N omega-nitro-L-arginine (30-100 mg/kg) attenuated the response to hypoxia, and caused the hypoxia induced roll-off of phrenic nerve activity to occur significantly earlier than when NOS activity was not inhibited. "
2.	Hypertension (High Blood Pressure) 10/01/2001 - "Effects of NG-nitro-L-arginine on the blood pressure of spontaneously hypertensive rats with different degrees of hypertension." 07/01/1999 - "Strain differences of hypertension induced by dietary NG-nitro-L-arginine in normotensive rats." 12/01/1997 - "N omega-nitro-L-arginine (15 mg/kg per day) in SHRSP-S (n=6) abrogated the increase in cortical NO but further augmented the hypertension and accelerated lesion development. " 07/01/1997 - "Chronic treatment of normotensive SD rats with the NO synthesis inhibitor, N omega-nitro-L-arginine (L-NNA; 0.5 g.L-1 in drinking water for 2 weeks), resulted in sustained hypertension. " 11/01/1994 - "Fish protein-rich diet attenuates hypertension induced by dietary NG-nitro-L-arginine in normotensive Wistar-Kyoto rats."
3.	Brain Ischemia (Cerebral Ischemia) 03/01/2003 - "Post-ischemic administration [correction of administeration] but not pre-ischemic administration [correction of administeration] of NG-nitro-L-arginine prevents spatial memory impairments and apoptosis by an inhibition of a delayed increase in NOx- in the hippocampus following repeated cerebral ischemia." 08/07/1998 - "This increase in [3H]L-N(G)-nitroarginine binding may play a pivotal role not only in the pathogenesis of ischemic brain damage, but also in the restoration of injury areas after cerebral ischemia." 04/01/1997 - "N omega-nitro-L-arginine attenuates early ischemic neuronal damage of prolonged focal cerebral ischemia and recirculation in rats." 05/02/1994 - "Neuroprotective efficacy of N omega-nitro-L-arginine after focal cerebral ischemia in the mouse and inhibition of cortical nitric oxide synthase." 07/01/1999 - "In the present study NOS activities were evaluated in cerebellum and cerebral cortex of ischemic and post-ischemic reperfused rats using an experimental model of partial cerebral ischemia; moreover, the effects of L-N(G)Nitroarginine (NA, nonselective NOS inhibitor) or 7-Nitroindazole (7-NI, selective neuronal NOS inhibitor) administration were assayed on percentage survival of ischemic rats. "
4.	Hypotension (Low Blood Pressure) 12/01/1996 - "Similar experiments performed with the nonspecific NOS inhibitor N omega-nitro-L-arginine (NNA) also demonstrated an increased pressor sensitivity of the cirrhotic rats, but the arterial hypotension was completely corrected. " 09/01/1994 - "Injection of nitroarginine during hypotension, without control of pressor effects, increased aortic and pial artery pressure approximately twofold. " 09/01/1994 - "Intravenous nitroarginine reduced blood flow to normal cerebrum by approximately 40% (p < 0.05) during normotension and hypotension, with aortic pressure maintained constant after nitroarginine administration. " 01/01/1993 - "Pretreatment with N omega-nitro-L-arginine (50 mg/kg, i.v.) produced an increase in mean arterial blood pressure and completely abolished the LPS-induced hypotension. " 04/01/1994 - "In contrast, both the hypotension and bleeding were attenuated by the selective antagonist of EDRF synthesis, NG-nitro-L-arginine. "
5.	Pulmonary Hypertension (Ayerza Syndrome) 11/01/1995 - "6. In conclusion, the onset of pulmonary hypertension in sheep following air embolization, is associated with the development of resistance of endothelium-dependent relaxations to block by L-NOARG. " 11/01/1995 - "Endothelium-dependent relaxations in sheep pulmonary arteries and veins: resistance to block by NG-nitro-L-arginine in pulmonary hypertension." 11/01/1991 - "In addition, L-arginine partially reversed the pulmonary hypertension induced by N omega-nitro-L-arginine, a competitive EDRF synthesis inhibitor, but D-arginine had no hemodynamic effects. " 05/01/1995 - "In this model of porcine endotoxin shock, the combination of NG-nitro-L-arginine infusion and nitric oxide inhalation attenuated pulmonary hypertension and improved gas exchange; it also prevented development of further systemic hypotension, but impaired cardiac output and increased systemic and renal vascular resistances to supranormal levels. " 04/01/1993 - "During pulmonary hypertension induced by N omega-nitro-L-arginine, the decreases in pulmonary arterial pressure and pulmonary vascular resistance produced by acetylcholine (9.6 +/- 6.4% and 23.9 +/- 14.1%, respectively) were significantly attenuated (p < 0.05), but the decreases produced by hyperoxia or alkalosis were unchanged. "

Related Drugs and Biologics

1.	Nitric Oxide Synthase (NO Synthase)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	NG-Nitroarginine Methyl Ester (L-NAME)
4.	Acetylcholine (Acetylcholine Chloride)
5.	Arginine (L-Arginine)
6.	Nitroarginine (NG Nitro L Arginine)
7.	Indomethacin (Indometacin)
8.	Carrageenan
9.	7-nitroindazole
10.	Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1.	Solid-State Lasers
2.	Intravenous Injections
3.	Oral Administration
4.	Surgical Instruments (Clip)
5.	Aftercare (After-Treatment)