Endothelin-2

A 21-amino acid peptide produced predominantly within the kidney and intestine, with smaller amounts produced in the myocardium, placenta, and uterus, but the cells of origin are not clear. Endothelin-2 has no unique physiologic functions, as compared with endothelin-1. (N Eng J Med 1995;333(6):356-63)

Also Known As:

Networked: 57 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Meidan, Rina: 3 articles (01/2015 - 04/2010)
2.	Balkwill, Frances R: 3 articles (04/2004 - 09/2002)
3.	Grimshaw, Matthew J: 3 articles (04/2004 - 09/2002)
4.	Emoto, Noriaki: 2 articles (08/2022 - 11/2021)
5.	Hirata, Ken-Ichi: 2 articles (08/2022 - 11/2021)
6.	Suzuki, Yoko: 2 articles (08/2022 - 11/2021)
7.	Cacioppo, Joseph A: 2 articles (11/2017 - 02/2015)
8.	Gal, Arnon: 2 articles (11/2017 - 02/2015)
9.	Ko, CheMyong: 2 articles (11/2017 - 02/2015)
10.	Lin, Po-Ching Patrick: 2 articles (11/2017 - 02/2015)

Related Diseases

1.	Pulmonary Fibrosis (Fibrosing Alveolitis) 11/02/2021 - "Protective Effects of Endothelin-2 Expressed in Epithelial Cells on Bleomycin-Induced Pulmonary Fibrosis in Mice."
2.	Ischemia 01/01/1999 - "Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo." 04/01/1995 - "This study was designed to investigate the changes in plasma and tissue endothelin-1/endothelin-2 (ET) after liver ischemia and to assess the protective effect of anti-ET 1/ET 2 monoclonal antibody (ET antibody) against ischemia-reperfusion injury. "
3.	Reperfusion Injury 04/01/1995 - "This study was designed to investigate the changes in plasma and tissue endothelin-1/endothelin-2 (ET) after liver ischemia and to assess the protective effect of anti-ET 1/ET 2 monoclonal antibody (ET antibody) against ischemia-reperfusion injury. "
4.	Multiple Sclerosis 04/01/2013 - "In studies to identify the receptor responsible for this regenerative effect of endothelin 2, analysis of both remyelination following experimental demyelination and of different stages of multiple sclerosis lesions in human post-mortem tissue revealed high levels of endothelin receptor type B in oligodendrocyte lineage cells. "
5.	Demyelinating Diseases (Demyelinating Disease) 04/01/2013 - "In studies to identify the receptor responsible for this regenerative effect of endothelin 2, analysis of both remyelination following experimental demyelination and of different stages of multiple sclerosis lesions in human post-mortem tissue revealed high levels of endothelin receptor type B in oligodendrocyte lineage cells. "

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Endothelin-1 (Endothelin 1)
3.	Endothelin Receptors (Endothelin Receptor)
4.	Monoclonal Antibodies
5.	Endothelin-3 (Endothelin 3)
6.	Endothelins (Endothelin)
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Complementary DNA (cDNA)
9.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Nephrectomy