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Endothelin-1 (Endothelin 1)

A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Also Known As:
Endothelin 1; Big Endothelin; Big Endothelin-1; Endothelin Type 1; Endothelin, Big; Preproendothelin; Preproendothelin-1; Proendothelin (1-38); Proendothelin-1 Precursor; Big Endothelin 1; Endothelin-1, Big; Precursor, Proendothelin-1; Preproendothelin 1; Proendothelin 1 Precursor
Networked: 6382 relevant articles (127 outcomes, 873 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bagnato, Anna: 51 articles (04/2022 - 03/2002)
2. Rosanò, Laura: 46 articles (01/2021 - 03/2002)
3. Di Castro, Valeriana: 35 articles (04/2022 - 03/2002)
4. Spinella, Francesca: 32 articles (11/2014 - 03/2002)
5. Pollock, David M: 26 articles (01/2022 - 05/2002)
6. Schiffrin, Ernesto L: 24 articles (01/2021 - 02/2002)
7. Natali, Pier Giorgio: 24 articles (04/2014 - 08/2002)
8. Matsumura, Yasuo: 24 articles (09/2013 - 08/2002)
9. Yanagisawa, Masashi: 23 articles (01/2016 - 08/2002)
10. Barton, Matthias: 20 articles (01/2020 - 05/2000)

Related Diseases

1. Pulmonary Hypertension
2. Heart Failure
3. Hypertension (High Blood Pressure)
4. Fibrosis (Cirrhosis)
5. Ischemia

Related Drugs and Biologics

1. Nitric Oxide (Nitrogen Monoxide)
2. Vasoconstrictor Agents
3. Angiotensin II
4. Bosentan (Tracleer)
5. Peptides (Polypeptides)
6. Endothelin-1 (Endothelin 1)
7. Biomarkers (Surrogate Marker)
8. Endothelin Receptors (Endothelin Receptor)
9. Endothelin Receptor Antagonists
10. Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1. Therapeutics
2. Pneumonectomy (Lung Volume Reduction)
3. Liver Transplantation
4. Glycemic Control
5. Gastrectomy