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3-O-Methylglucose (3 O Methylglucose)

A non-metabolizable glucose analogue that is not phosphorylated by hexokinase. 3-O-Methylglucose is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems. (J Neurochem 1993;60(4):1498-504)
Also Known As:
3 O Methylglucose; 3 O Methyl D Glucose; 3-O-Methyl-D-Glucose; D-glucose, 3-O-methyl-
Networked: 98 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Navon, Gil: 3 articles (10/2018 - 11/2014)
2. Rivlin, Michal: 3 articles (10/2018 - 11/2014)
3. Wu, Tongzhi: 2 articles (01/2022 - 01/2017)
4. Cheng, Zhiqiang: 1 article (01/2022)
5. Dong, Shuohui: 1 article (01/2022)
6. Hu, Sanyuan: 1 article (01/2022)
7. Rayner, Christopher: 1 article (01/2022)
8. Wang, Kexin: 1 article (01/2022)
9. Zhang, Guangyong: 1 article (01/2022)
10. Zhang, Xiang: 1 article (01/2022)

Related Diseases

1. Insulin Resistance
09/01/1990 - "Mechanism of insulin resistance in the post receptor events in sheep: 3-O-methylglucose transport in ovine adipocytes."
10/01/1985 - "Starvation-induced insulin resistance: influence on 3-O-methylglucose transport."
02/01/2002 - "With brief time-matched CR, reduced visceral fat mass precedes increased insulin sensitivity; transient reduction in fructose 6-phosphate may trigger more persistent changes but does not coincide with enhanced insulin action; and PI3K is essential for insulin-stimulated 3-O-methylglucose transport in CR as well as AL rats, although insulin-stimulated PI3K is not significantly greater in CR compared with AL animals."
02/01/1994 - "We found that, although rat epitrochlearis muscles stimulated to contract in vitro after 15 min of incubation in Krebs-Henseleit buffer did not develop increased insulin sensitivity, muscles stimulated to contract immediately after being dissected showed a small but significant enhancement of the stimulation of 3-O-methyl-D-glucose transport by 30 microU/ml insulin. "
10/01/1985 - "After electrical stimulation of diabetic hindquarters in the presence of insulin antiserum, insulin sensitivity of 3-O-methylglucose transport was increased to the same extent as in muscle from healthy rats stimulated in the presence of insulin at 50 microU/ml. Furthermore, in muscle depleted of glycogen by contractions, transport of 3-O-methylglucose was increased in the presence of insulin antiserum and in the absence of increased regional perfusate flow. "
2. Poisoning
3. Sarcoma (Soft Tissue Sarcoma)
4. Neuroblastoma
5. Dehydration (Water Stress)

Related Drugs and Biologics

1. Glucose (Dextrose)
2. Insulin (Novolin)
3. Fructose
4. Alloxan
5. Hexoses
6. Sugars
7. Lactase
8. Hydroxyl Radical
9. Tretinoin (Retinoic Acid)
10. Tetradecanoylphorbol Acetate

Related Therapies and Procedures

1. Catheters
2. Ketogenic Diet
3. Injections
4. Ileostomy
5. Enteral Nutrition (Feeding, Tube)