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Rolandic Epilepsy (Centrotemporal Epilepsy)

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An autosomal dominant inherited partial epilepsy syndrome with onset between age 3 and 13 years. Seizures are characterized by PARESTHESIA and tonic or clonic activity of the lower face associated with drooling and dysarthria. In most cases, affected children are neurologically and developmentally normal. (From Epilepsia 1998 39;Suppl 4:S32-S41)

Also Known As:

Centrotemporal Epilepsy; Epilepsy, Rolandic; BCECTS; BECTS; Benign Rolandic Epilepsy; Centralopathic Epilepsy; Benign Childhood Epilepsy With Centro Temporal Spikes; Centralopathic Epilepsies; Centrotemporal Epilepsies; Epilepsies, Centralopathic; Epilepsies, Centrotemporal; Epilepsies, Rolandic; Epilepsy, Benign Rolandic; Epilepsy, Centralopathic; Epilepsy, Rolands; Epilepsy, Sylvian; Rolandic Epilepsies; Rolandic Epilepsy, Benign; Benign Childhood Epilepsy With Centro-Temporal Spikes; Benign Epilepsy With Centrotemporal Spikes; Benign Rolandic Epilepsy of Childhood; Epilepsy, Centrotemporal; Rolands Epilepsy; Sylvian Epilepsy

Networked: 90 relevant articles (6 outcomes, 20 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 6158
- Central Nervous System Diseases: 1649
  - Brain Diseases: 2114
    - Epilepsy: 22953
      - Partial Epilepsies: 1729
        Rolandic Epilepsy: 90
        rolandic with paroxysmal exercise-induced dystonia and writer's cramp Epilepsy

Related Diseases

1.	Seizures (Seizure)
2.	Epilepsy (Aura)
3.	Juvenile Myoclonic Epilepsy
4.	Absence Epilepsy (Absence Seizure)
5.	Rolandic Epilepsy (Centrotemporal Epilepsy)

Experts

1.	Neubauer, Bernd A: 3 articles (06/2015 - 01/2006)
2.	Filippini, Melissa: 3 articles (05/2015 - 01/2006)
3.	Verrotti, Alberto: 3 articles (02/2014 - 06/2007)
4.	Pal, Deb K: 2 articles (12/2015 - 12/2007)
5.	Strug, Lisa J: 2 articles (12/2015 - 12/2007)
6.	Clarke, Tara: 2 articles (12/2015 - 12/2007)
7.	Lerche, Holger: 2 articles (09/2015 - 06/2015)
8.	Nürnberg, Peter: 2 articles (09/2015 - 06/2015)
9.	Sander, Thomas: 2 articles (09/2015 - 06/2015)
10.	Toliat, Mohammad R: 2 articles (09/2015 - 06/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rolandic Epilepsy:

1.	etiracetam (levetiracetam)FDA LinkGeneric 02/01/2010 - "Several recent studies have shown that levetiracetam (LEV) can be beneficial in the treatment of children with typical rolandic epilepsy (RE). " 01/01/2014 - "Two ongoing studies comparing STM monotherapy versus placebo or levetiracetam in BECTS were identified. " 05/01/2015 - "The formal evidence for levetiracetam monotherapy in children is minimal: it is potentially efficacious or effective as initial monotherapy in children with benign epilepsy with centrotemporal spikes. " 12/01/2007 - "A pilot study transitioning children onto levetiracetam monotherapy to improve language dysfunction associated with benign rolandic epilepsy." 04/01/2003 - "We present three clinical cases of otherwise healthy children with BECTS who were treated only with levetiracetam. "
2.	sulthiame (sultiam)IBA 01/01/2005 - "Thirty-nine children with BECTS from our department (aged 3-11 years) were analyzed as candidates to be enrolled in a prospective multicenter randomized double-blind placebo controlled study on therapeutic efficacy of sulthiame. " 02/01/1999 - "A previously unpublished side effect of sulthiame in a patient with Rolandic epilepsy." 01/01/2014 - "There is evidence from one trial reviewed that sulthiame is effective for seizure remission in the short term in children with BECTS although the precision of the effect estimate is uncertain due to its small sample size. " 02/01/2003 - "To evaluate the effects of sulthiame (Ospolot; STM) monotherapy compared with placebo on the EEG in children with benign childhood epilepsy with centrotemporal spikes (BECTS). " 02/01/2003 - "The influence of sulthiame on EEG in children with benign childhood epilepsy with centrotemporal spikes (BECTS)."
3.	Anticonvulsants (Antiepileptic Drugs)IBA 08/14/2001 - "Forty-three of 79 children (54%) with benign rolandic epilepsy from a regional population were treated with antiepileptic drugs (AED); 36 (46%) were not. " 06/01/2001 - "Aggravation of BECTS caused by antiepileptic drugs happens only rarely. " 06/01/2011 - "A changed EEG record in a patient with rolandic epilepsy must not be a predictor of continuation of antiepileptic drugs therapy, after 2-3 years of successful seizures remission." 01/01/2012 - "The aim of this study was to investigate behavioral problems in two groups of children with benign childhood epilepsy with centrotemporal spikes (BECTS), i.e., those treated with antiepileptic drugs and those not treated in order to identify the factors associated with behavioral problems. " 02/01/2005 - "Even though 65.6% were on anticonvulsants due to frequent seizures and/or seizures while awake, none belonged to the atypical BCECTS spectrum with respect to clinical or EEG findings. "
4.	Lennox-Gastaut type Epileptic encephalopathyIBA 06/01/2012 - "Atonic-BECTS needs to be differentiated from Lennox-Gastaut syndrome since it is potentially treatable and children recover with no sequel. " 07/01/1999 - "Benign rolandic epilepsy-PR 0.2/1,000-was the most frequent among idiopathic syndromes, and Lennox-Gastaut syndrome-PR 0.08/1,000-was the most frequent among cryptogenic ones. " 11/01/2010 - "Episodes of convulsive status epilepticus can occur in each: occasionally in symptomatic and febrile convulsions, and Lennox Gastaut syndrome, rarely in benign rolandic epilepsy, and West syndrome. " 06/01/2013 - "EEG-fMRI studies in focal epilepsy (structural and nonlesional cases, benign epilepsy with centrotemporal spikes), generalized epilepsy (especially absence epilepsy), and epileptic encephalopathies (West syndrome, Lennox-Gastaut syndrome, continuous spike and waves during slow sleep, and Dravet syndrome) are presented. " 03/01/2006 - "For each of the epilepsy subtypes considered in RCTs identified for this review (partial epilepsy with or without secondary generalisation, Lennox-Gastaut syndrome, infantile spasms, absence epilepsy and benign epilepsy with centrotemporal spikes), there is some evidence from placebo-controlled trials that the newer agents tested are of some value in the treatment of these conditions. "
5.	oxcarbazepine (Trileptal)FDA LinkGeneric 08/01/2014 - "BECTS patients receiving oxcarbazepine monotherapy were retrospectively reviewed. " 08/01/2014 - "The aim of this study was to detect clinical variables associated with the extent of change of the irritative zone in benign epilepsy of childhood with centrotemporal spikes (BECTS) after oxcarbazepine monotherapy. " 11/01/2005 - "We report on 70 patients (aged 5.2-11.6 years) newly diagnosed with benign childhood epilepsy with centrotemporal spikes (BECTS) who were assigned to oxcarbazepine (OXC) monotherapy. " 04/01/2015 - "We describe a child with benign epilepsy with centrotemporal spikes (BECTS) in whom treatment with oxcarbazepine (OXC) induced ESES. " 06/01/2007 - "These preliminary data from an open, parallel group study suggest that levetiracetam and oxcarbazepine may be potentially effective and well tolerated drugs for children with BECTS who require treatment."
6.	Carbamazepine (Tegretol)FDA LinkGeneric 11/01/2005 - "Acoustic effects of carbamazepine in benign rolandic epilepsy." 11/01/2002 - "During the antiepilepsy treatment, 6 of 66 patients with rolandic epilepsy, most of them with initial carbamazepine therapy, had absences and generalized spike-wave discharges of a secondarily generalized type. " 09/01/2000 - "Patient 1, a 9-year-old boy with benign Rolandic epilepsy, developed impairment of pitch perception one day after administration of carbamazepine. " 11/01/1999 - "Comparisons with reliable change indices identified two subjects with benign rolandic epilepsy with particularly poor scores while receiving carbamazepine. " 11/01/1999 - "We found that children with benign rolandic epilepsy were quicker on a visual-search task and recalled stories better when not treated than when treated with carbamazepine. "
7.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 06/01/2011 - "With a clear correlation of EEG record, benign rolandic epilepsy was diagnosed, so the therapy with valproate was introduced. " 11/01/2010 - "Thus, if treatment is planned, valproic acid may be considered the drug of choice in BECTS. " 12/01/2007 - "For benign childhood epilepsy with centro-temporal spikes, valproate was treatment of choice. " 03/01/1997 - "Motor cortical excitability was studied using transcranial magnetic stimulation (TMS) in 10 age-matched controls, and 13 children with benign childhood epilepsy with centro-temporal spikes (BECT), with a mean age of 11.2 +/- 2.0 years (five untreated, and eight treated with sodium valproate (VPA) and well controlled). " 10/01/2014 - "This study aimed to compare the monotherapeutic efficacies of levetiracetam (LEV) and valproic acid (VPA) in a cohort of newly diagnosed children with typical benign childhood epilepsy with centrotemporal spikes (BECTS). "
8.	Silver Sulfadiazine (SSD)FDA LinkGeneric 12/01/2007 - "Associations between rolandic epilepsy (RE) with reading disability (RD) and speech sound disorder (SSD) have not been tested in a controlled study. " 12/01/2015 - "The high prevalence and impact of neurodevelopmental comorbidities in childhood epilepsy are now well known, as are the increased risks and familial aggregation of reading disability (RD) and speech sound disorder (SSD) in rolandic epilepsy (RE). "
9.	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/01/2014 - "We conducted a case-control association study on 60 patients with BECTS and 60 control participants to assess the influence of the BDNF and ELP4 polymorphisms on BECTS. " 12/01/2014 - "Recent reports on the involvement of the BDNF and ELP4 genes in cell motility, migration, and adhesion raise the possibility that these genes are involved in pathogenesis of BECTS. " 12/01/2014 - "Association of brain-derived neurotrophic factor (BDNF) and elongator protein complex 4 (ELP4) polymorphisms with benign epilepsy with centrotemporal spikes in a Greek population."
10.	Phenytoin (Dilantin)FDA LinkGeneric 01/01/2014 - "STM was given as monotherapy compared with placebo in the BECTS studies and compared with phenytoin in the GTCS study. "

Therapies and Procedures

1.	Exercise Therapy (Therapy, Exercise) 08/01/2014 - "The purposes of the current study were to test the feasibility of exercise therapy for children with benign epilepsy with centrotemporal spikes (BECTS) and to collect pilot data about the impact of exercise therapy on neurocognitive, emotional, and behavioral outcomes. "
2.	Electrodes (Electrode) 12/01/2014 - "Results revealed high amplitude of AERPs for the group of children with BECTS with a slight latency delay more pronounced in fronto-central electrodes. " 08/01/2009 - "In this subgroup, relative alpha amplitudes at the central and parietal electrodes were lower as compared with those of the BECTS subgroup with normal educational performance and a control group matched for age, gender, and socioeconomic status. " 07/01/2006 - "In the children with BECTS, a negative correlation (Pearson's correlation test) was observed at various electrodes between the absolute delta and theta powers and the performance IQ. " 07/01/2006 - "It was shown that the absolute delta and theta powers were statistically greater in the children with BECTS than in the control group, at almost all the electrodes. "
3.	Surgical Instruments (Clip) 01/15/2014 - "The FA value was significantly lower in the body of the corpus callosum and forceps minor in BECTS patients with spikes on the ipsilateral hemisphere. "
4.	Speech Therapy (Therapy, Speech) 05/15/2011 - "23% of children with Rolandic epilepsy had speech therapy in the past and 35% repeated a year on primary school, which is more often compared to the Dutch population of children. "