2,4-Dinitrophenol (2,4 Dinitrophenol)

A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)

Also Known As:

Networked: 212 relevant articles (4 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shulman, Gerald I: 3 articles (03/2015 - 07/2004)
2.	Love, Nancy G: 3 articles (09/2007 - 07/2005)
3.	Henriques, Inês D S: 3 articles (09/2007 - 07/2005)
4.	Lu, Yuan-qiang: 2 articles (08/2015 - 03/2011)
5.	Jiang, Jiu-kun: 2 articles (08/2015 - 03/2011)
6.	Zhang, Dongyan: 2 articles (03/2015 - 11/2013)
7.	Perry, Rachel J: 2 articles (03/2015 - 11/2013)
8.	Zhang, Xian-Man: 2 articles (03/2015 - 11/2013)
9.	Ferreira, Sergio T: 2 articles (11/2013 - 05/2010)
10.	da Costa, Rodrigo F Madeiro: 2 articles (11/2013 - 05/2010)

Related Diseases

1.	Poisoning 08/01/2015 - "We reported 16 cases of acute 2,4-DNP poisoning through occupational exposure due to ignoring the risk of poisoning. " 03/01/2011 - "A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. " 03/01/2011 - "To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning. " 03/01/2011 - "Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning." 08/01/2010 - "'Fatal 2,4-dinitrophenol poisoning... "
2.	Spinal Cord Injuries (Spinal Cord Injury) 10/01/2004 - "The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury. " 01/01/2009 - "Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury."
3.	Body Weight (Weight, Body) 11/01/1983 - "A single ip administration of 2,4-dinitrophenol (0.1 mg/100 g body weight), an inhibitor of oxidative phosphorylation, did not prevent significant increases in phosphorus contents of the homogenate and the mitochondria caused by administration of CT (80 MRC mU/100 g body weight), although the drug markedly inhibited ATPase activity in the mitochondria. " 08/01/2008 - "Treatment of mice with low doses of the protonophore 2,4-dinitrophenol promotes enhanced tissue respiratory rates, improved serological glucose, triglyceride and insulin levels, decrease of reactive oxygen species levels and tissue DNA and protein oxidation, as well as reduced body weight. " 01/01/1976 - "It was found in white rats that hyperthyreosis (0.5% thyreoidin in dry food), respectively 2,4-dinitrophenol (30 mg/kg body weight/day i. p.), deficiency of the vitamins K and E or complete fasting increase the content of creatine in muscle, plasma and urine, but reduce the concentration of creatinine. "
4.	Retinal Detachment (Retinal Detachments) 04/01/2005 - "The authors evaluated the efficacy of 2,4-dinitrophenol (2,4-DNP) to promote retinal detachment in the rabbit. " 04/01/2005 - "A retinal detachment was present in three of six masked and two of two unmasked 2,4-DNP treated eyes and none of eight BSS+ treated eyes. " 04/01/2005 - "2,4-Dinitrophenol pharmacologically promotes retinal detachment in rabbits."
5.	Anoxia (Hypoxia) 01/01/1991 - "Hypoxia-reflow studies performed in the presence of 25 microM 2,4-dinitrophenol (DNP) showed a drastic enhancement in LDH (244%) and protein (104%) efflux from the liver, compared with the effects found in its absence, with a moderate increase (35%) in tissue TBAR levels. " 09/01/1985 - "In a previous study, it was suggested that inhibition of oxidative phosphorylation in smooth muscle is accompanied by a release of Ca2+ from mitochondria (Pettersson 1983); in this investigation, the effects of 2,4-dinitrophenol (DNP) and anoxia on isometric tension in pieces of smooth muscle from rabbit colon were studied. " 11/01/2009 - "The K(+) current was increased in wild type cells, but not in cells expressing Delta M-LDH/193gly-M-LDH, when they were exposed to chemical hypoxia induced by 2,4 dinitrophenol (DNP; 10mM). " 01/01/2004 - "Effect of the oxidative phosphorylation uncoupler 2,4-dinitrophenol on hypoxia-inducible factor-regulated gene expression in bovine blastocysts." 06/01/2001 - "Chemical hypoxia-reoxygenation was induced by application and removal of the mitochondrial poison 2,4 dinitrophenol (DNP). "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Insulin (Novolin)
3.	DNA (Deoxyribonucleic Acid)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Adenosine Triphosphate (ATP)
6.	Cycloheximide (Cicloheximide)
7.	Calcium
8.	Uncoupling Agents
9.	mesoxalonitrile
10.	Cyclosporine (Ciclosporin)

Related Therapies and Procedures

1.	Hemoperfusion
2.	Bioreactors
3.	Injections
4.	Therapeutics
5.	Lasers (Laser)