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Megestrol Acetate (Borea)

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Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

Also Known As:

Borea; Megace; Apo-Megestrol; Apotex Brand of Megestrol Acetate; Bristol-Myers Brand of Megestrol Acetate; Bristol-Myers Squibb Brand of Megestrol Acetate; Lemery Brand of Megestrol Acetate; Lin-Megestrol; Linson Pharma Brand of Megestrol Acetate; Madaus Brand of Megestrol Acetate; Maygace; Megefren; Megestat; Megostat; Mestrel; Nu-Megestrol; Nu-Pharm Brand of Megestrol Acetate; Prasfarma Brand of Megestrol Acetate; Squibb Brand of Megestrol Acetate; Acetate, Megestrol; Apo Megestrol; ApoMegestrol; Bristol Myers Brand of Megestrol Acetate; Bristol Myers Squibb Brand of Megestrol Acetate; Lin Megestrol; LinMegestrol; Nu Megestrol; Nu Pharm Brand of Megestrol Acetate; NuMegestrol

Networked: 583 relevant articles (74 outcomes, 190 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Pregnanes: 3
    - Pregnadienes
      - Megestrol: 80
        Megestrol Acetate: 583
        Oraconal: 21
        cymegesolate
        Me-quingestanol
        PAV-M protocol

Experts

1.	Evans, William J: 5 articles (02/2007 - 05/2002)
2.	Buzdar, Aman U: 5 articles (01/2004 - 11/2002)
3.	Schuster, M W: 4 articles (05/2009 - 01/2000)
4.	Novotny, Paul J: 4 articles (07/2008 - 01/2002)
5.	Sloan, Jeff A: 4 articles (07/2008 - 01/2002)
6.	Loprinzi, Charles L: 4 articles (07/2008 - 01/2002)
7.	Jatoi, Aminah: 4 articles (10/2006 - 01/2002)
8.	Lambert, Charles P: 4 articles (09/2005 - 05/2002)
9.	Sullivan, Dennis H: 4 articles (09/2005 - 05/2002)
10.	Lai, Chyong-Huey: 3 articles (05/2014 - 04/2002)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 04/01/1988 - "These data indicate that high-dose megestrol acetate is well tolerated and effective in patients with advanced breast cancer refractory to multiple previous therapies. " 10/01/1996 - "Megestrol acetate is an effective treatment for advanced breast cancer in older women when used either as first- or second-line treatment. " 08/01/1991 - "To determine the tolerability and efficacy of increasing doses of megestrol acetate in the treatment of metastatic breast cancer, we conducted a phase I/II study among 57 patients. " 12/01/2008 - "Goodwin et al. have performed a 6-month, double-blind, randomized, placebo-controlled trial of megestrol acetate in 286 women with breast cancer. " 04/01/2008 - "Phase III randomized placebo-controlled trial of two doses of megestrol acetate as treatment for menopausal symptoms in women with breast cancer: Southwest Oncology Group Study 9626."
2.	Neoplasms (Cancer) 01/01/1993 - "Studies have demonstrated that megestrol acetate has the most positive results in patients with advanced cancer and human immunodeficiency virus. " 03/01/1997 - "Improved quality of life with megestrol acetate in patients with endocrine-insensitive advanced cancer: a randomised placebo-controlled trial. " 07/06/2002 - "A systematic review of randomized clinical trials comparing megestrol acetate with placebo in cancer patients was performed. " 10/01/1998 - "The aim of this study was to evaluate a low-dose regimen of megestrol acetate (MA; 320 mg/day) on appetite in advanced cancer patients. " 10/01/1992 - "To assess the effect of megestrol acetate (MA) on the appetite and weight of cancer patients with nonhormone-dependent tumors, a double-blind, placebo-controlled trial was designed. "
3.	Anorexia 01/01/2013 - "In addition to exercise training, administration of megestrol acetate has been proven to be effective in improving anorexia and muscle wasting in HD patients. " 05/21/2014 - "Anorexia and megestrol acetate: treatment versus placebo controlled study." 01/01/2010 - "[Treatment of uraemic anorexia with megestrol acetate]." 01/01/2006 - "Megestrol acetate use for anorexia in the older subject." 02/01/1994 - ""Treatment of anorexia with megestrol acetate"."
4.	Cachexia 05/01/1989 - "Nursing interventions to stimulate appetite and promote greater food intake, coupled with the use of agents that alter metabolism, such as megestrol acetate, may reverse the trend of cachexia and thus provide an increased sense of well-being and improved quality of life." 08/01/1998 - "Anticachectic efficacy of megestrol acetate at different doses and versus placebo in patients with neoplastic cachexia." 01/01/2010 - "Report of a pilot, double-blind, placebo-controlled study of megestrol acetate in elderly dialysis patients with cachexia." 01/01/2006 - "The aim is to review major clinical trials that have used megestrol acetate (MA) in the treatment of cachexia across several disease states. " 12/01/1990 - "The true effectiveness of megestrol acetate for HIV-related cachexia and the effects of treatment on quality of life are currently being assessed in a national prospective, randomized, double-blind, placebo-controlled trial."
5.	Weight Gain 04/01/2002 - "Short-term use of megestrol acetate results in significant weight gain and improved pulmonary function in malnourished subjects with CF. " 10/01/1994 - "Megestrol acetate-treated patients had a significantly greater mean maximum weight gain (p = 0.027) and appetite stimulation (p = 0.021) than did placebo-treated patients. " 09/15/1994 - "Compared with patients receiving placebo at the time of maximum weight change, evaluable patients receiving megestrol acetate, 800 mg/d, reported improvement in overall well-being and had an increase in mean weight gain (-0.725 compared with 3.54 kg [-1.6 compared with +7.8 pounds]; P < 0.001), lean body mass (-0.772 compared with +1.14 kg [-1.7 compared with +2.5 pounds]; P < 0.001), appetite grade (P < 0.001), and caloric intake (-107 compared with +645.6 calories/d; P = 0.001). " 09/01/2000 - "The purpose of this study was to determine whether the administration of megestrol acetate (MA) induces weight gain in malnourished patients with CF, and to assess the composition of weight gain. " 08/01/1992 - "Several randomized studies have shown that megestrol acetate, possibly in a dose-dependent fashion, can improve appetite and lead to weight gain. "

Related Drugs and Biologics

1.	Tamoxifen
2.	Hormones
3.	letrozole (Femara)
4.	Medroxyprogesterone Acetate (Depo-Provera)
5.	Progestins (Progestagens)
6.	anastrozole (Arimidex)
7.	exemestane (Aromasin)
8.	Aromatase Inhibitors
9.	Megestrol Acetate (Borea)
10.	Aminoglutethimide (Cytadren)

Related Therapies and Procedures

1.	Palliative Care (Palliative Medicine)
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Radiotherapy
5.	Home Nursing (Nursing, Home)