Acute Necrotizing Pancreatitis

A severe form of acute INFLAMMATION of the PANCREAS characterized by one or more areas of NECROSIS in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. Massive pancreatic necrosis may lead to DIABETES MELLITUS, and malabsorption.

Also Known As:

Networked: 428 relevant articles (27 outcomes, 87 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Pancreatitis
3.	Necrosis
4.	Inflammation
5.	Acute Lung Injury

Experts

1.	Comert, Bilgin: 11 articles (05/2012 - 11/2002)
2.	Deveci, Salih: 9 articles (05/2012 - 11/2002)
3.	Mas, Nuket: 9 articles (12/2007 - 11/2002)
4.	Alhan, Etem: 8 articles (01/2015 - 03/2002)
5.	Yasar, Mehmet: 8 articles (09/2011 - 11/2002)
6.	Wu, Kai: 6 articles (05/2015 - 08/2002)
7.	Xue, Ping: 6 articles (01/2015 - 02/2008)
8.	Hopt, Ulrich T: 6 articles (05/2014 - 11/2006)
9.	Mas, M Refik: 6 articles (05/2012 - 11/2002)
10.	Tasci, Ilker: 6 articles (05/2012 - 10/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Necrotizing Pancreatitis:

1.	Atrial Natriuretic Factor (ANF)IBA 09/01/2010 - "Various studies have been performed to find out novel treatment strategies for acute necrotizing pancreatitis (ANP). " 10/01/2015 - "The aim of this study was to investigate the influence of the greater splanchnic nerve (GSN) transection on the pathophysiological process of acute necrotizing pancreatitis (ANP). " 02/01/2013 - "The aim of this study was to investigate the expression pattern of regenerating gene I (Reg I) in the lung and intestinal tissues of rats with acute necrotizing pancreatitis (ANP), as well as the correlation of Reg I expression with lung and intestinal injury. " 11/01/2011 - "The results of prospective and retrospective clinical study of 51 patients with acute necrotizing pancreatitis ANP. " 01/01/2015 - "However, the influence of visceral nerve (VN) on acute necrotizing pancreatitis (ANP) has drawn little attention. "
2.	MelatoninIBA 05/01/2012 - "Melatonin ameliorates acute necrotizing pancreatitis by the regulation of cytosolic Ca2+ homeostasis." 09/01/2004 - "Effects of melatonin on acute necrotizing pancreatitis in rats." 01/14/2006 - "Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis." 11/01/2010 - "[The expression of melatonin MT1 receptor in acute necrotizing pancreatitis rats and the protective effects of melatonin]." 06/01/2014 - "Melatonin reduces inflammation and recovers endogenous ghrelin in acute necrotizing pancreatitis in rats."
3.	ErythropoietinFDA Link 01/01/2009 - "The aim of the present study was to investigate the effects of erythropoietin on the severity of taurocolic acid-induced acute necrotizing pancreatitis. " 01/01/2009 - "Erythropoietin: a possible cytoprotective cytokine in acute necrotizing pancreatitis." 12/14/2007 - "Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis." 07/01/2009 - "Erythropoietin (EPO) elicits protective effects in lung ischemia-reperfusion, hyperoxia, acute necrotizing pancreatitis, and some other tissues. "
4.	CalciumIBA 05/01/1981 - "This indicates that serum total and ionized calcium is helpful in making the diagnosis of acute necrotizing pancreatitis. " 05/01/2012 - "This study aims to investigate the relationship between the protective effects of melatonin in pancreas and the expression of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) and Na(+)/Ca(2+) exchanger (NCX) in rats with acute necrotizing pancreatitis (ANP), to verify whether melatonin ameliorates ANP by alleviating calcium overload. "
5.	OxygenIBA 01/01/1994 - "To study the influence of experimentally induced acute necrotizing pancreatitis on jejunal oxygen transport, jejunal oxygen consumption, and mucosal PO2. " 10/01/2005 - "Hyperbaric oxygen-induced changes in bacterial translocation and acinar ultrastructure in rat acute necrotizing pancreatitis." 01/01/2003 - "The effect of hyperbaric oxygen treatment on oxidative stress in experimental acute necrotizing pancreatitis." 02/01/2012 - "This study was designed to evaluate the combined effects of hyperbaric oxygen (HBO) and N-acetylcysteine (NAC) on acute necrotizing pancreatitis in rats. " 01/01/1994 - "Our results demonstrate that, under conditions of sustained systemic hemodynamics, jejunal oxygen transport and mucosal oxygenation are well maintained during the early course of sodium-taurocholate-induced acute necrotizing pancreatitis."
6.	Octreotide (Sandostatin)FDA LinkGeneric 11/01/2011 - "Octreotide ameliorates intestinal dysmotility by interstitial cells of Cajal protection in a rat acute necrotizing pancreatitis model." 01/01/2012 - "Effect of octreotide on enteric motor neurons in experimental acute necrotizing pancreatitis." 07/15/2004 - "Effects of octreotide on acute necrotizing pancreatitis in rabbits." 12/01/1998 - "Owing to its complex effect, octreotide can partially ameliorate the deleterious consequences of acute necrotizing pancreatitis. " 01/01/1998 - "We conclude that octreotide improves pancreatic histopathology and survival in acute necrotizing pancreatitis in rats."
7.	ImipenemFDA Link 03/01/2001 - "This single-center randomized study was designed to compare early vs. delayed imipenem treatment for acute necrotizing pancreatitis. " 05/01/1993 - "Therefore, the authors recommend prophylactic use of imipenem in patients with acute necrotizing pancreatitis." 05/01/1993 - "A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem." 03/01/2009 - "to evaluate the capacity of Imipenem as a prophylactic treatment for decreasing the number of infected necrosis and surgeries, as well as for diminishing septic complications and the mortality rate among patients with severe acute necrotizing pancreatitis. " 11/01/2003 - "We compared two imipenem regimens for prevention of septic complications in patients with severe acute necrotizing pancreatitis (ANP). "
8.	Epoprostenol (Prostacyclin)FDA LinkGeneric 04/01/1995 - "[Protective effects of prostacyclin on acute necrotizing pancreatitis and its renal damage in rats]." 09/01/1990 - "Plasma thromboxane concentrations were found to be significantly elevated in acute necrotizing pancreatitis in rats, whereas prostaglandin I2 levels were not. " 09/01/1990 - "The results of the present study suggest that thromboxane A2 and prostaglandin I2 play a role in the course of acute necrotizing pancreatitis." 08/01/1998 - "The effects of a thromboxane A2 synthesis inhibitor and a prostaglandin I2 analogue on experimental acute necrotizing pancreatitis in rats." 09/01/1990 - "Significance of thromboxane A2 and prostaglandin I2 in acute necrotizing pancreatitis in rats."
9.	OzoneIBA 09/01/2011 - "Inhibition of iNOS reduces the therapeutic effects of ozone in acute necrotizing pancreatitis: an in vivo animal study." 10/01/2008 - "[Application of ozone therapy in complex treatment of patients with acute necrotizing pancreatitis]." 01/01/2010 - "Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis." 01/01/2010 - "Our aims were to evaluate the efficacy of ozone therapy (OT) in an experimental rat model of acute necrotizing pancreatitis (ANP) and to compare its effects with hyperbaric oxygen (HBO) therapy in this entity. " 09/01/2011 - "Previously, it was shown that ozone and S-methylthiourea (SMT) treatments had ameliorative effects on experimental models of acute necrotizing pancreatitis (ANP). "
10.	infliximab (Remicade)FDA Link 01/01/2015 - "Administration of infliximab resulted in a significant improvement in biochemical and histopathological alterations in acute necrotizing pancreatitis(Tab. " 05/01/2012 - "The present study was designed to assess the effects of infliximab treatment on bacterial translocation (BT) in experimental acute necrotizing pancreatitis. " 05/01/2012 - "Effects of infliximab on bacterial translocation in experimental acute necrotizing pancreatitis." 08/01/2012 - "Infliximab enhances the therapeutic effectiveness of octreotide on acute necrotizing pancreatitis in rat model." 08/01/2012 - "To investigate the synergistic activity of infliximab to the therapeutic effectiveness of octreotide in a rat model of acute necrotizing pancreatitis (ANP). "

Therapies and Procedures

1.	Antibiotic Prophylaxis 02/01/2005 - "We suggested that antibiotic prophylaxis with proven efficacy in necrotic pancreatic tissues should be given to all patients with acute necrotizing pancreatitis. " 05/01/2009 - "This study addresses whether antibiotic prophylaxis is beneficial for acute necrotizing pancreatitis. " 03/01/2015 - "Several studies have yielded conflicting results on the role of antibiotic prophylaxis in improving outcomes in acute necrotizing pancreatitis. " 09/01/2009 - "To review studies of antibiotic prophylaxis in acute necrotizing pancreatitis published in the last decade and update recommendations. " 06/01/1997 - "Recent clinical trials have assessed the role of both systemic antibiotic prophylaxis and selective bowel decontamination with nonabsorbable oral antimicrobials in high-risk patients with acute necrotizing pancreatitis. "
2.	Intra-Arterial Infusions 01/01/2005 - "New strategy for acute necrotizing pancreatitis: Continuous Regional Arterial Infusion (CRAI) therapy." 01/01/2001 - "Continuous regional arterial infusion (CRAI) therapy reduces the mortality rate of acute necrotizing pancreatitis: results of a cooperative survey in Japan." 01/01/2003 - "We have demonstrated that continuous regional arterial infusion (CRAI) of an antibiotic is more effective than intravenous administration in preventing pancreatic infection and improving survival, in a canine model of acute necrotizing pancreatitis. " 04/01/2013 - "Continuous regional arterial infusion effective for children with acute necrotizing pancreatitis even under neutropenia." 05/01/2009 - "Continuous regional arterial infusion therapy for acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection in a child."
3.	Debridement 03/01/1995 - "Improved survival in acute necrotizing pancreatitis despite limiting the indications for surgical debridement." 03/01/1992 - "Three patients with acute necrotizing pancreatitis (no surgery) were not cured by the interventional procedure and all required surgical debridement. " 08/01/2006 - "No debridement is necessary for symptomatic or infected acute necrotizing pancreatitis: delayed, mini-retroperitoneal drainage for acute necrotizing pancreatitis without debridement and irrigation." 06/01/2006 - "Pancreatic resection for severe acute necrotizing pancreatitis has been associated with prohibitive mortality rates and has been hence replaced by piecemeal debridement, either by the open or the laparoscopic technique. " 06/01/2002 - "Early debridement for acute necrotizing pancreatitis might not improve survival and might even be associated with increased number of complications. "
4.	Catheters 04/01/1998 - "Percutaneous catheter drainage is a safe and effective technique for treating infected acute necrotizing pancreatitis. " 04/01/1998 - "The objective of this paper was to assess the safety and efficacy of percutaneous catheter drainage for initial treatment of infected acute necrotizing pancreatitis. " 01/01/2009 - "In our experience, primary CT-guided percutaneous catheter drainage was successful for approximately one half of the patients with acute necrotizing pancreatitis. " 01/01/2009 - "We reviewed clinical, radiologic, and bacteriologic data on 35 patients (23 men, 12 women; mean age, 50 years; range, 21-83 years) with acute necrotizing pancreatitis refractory to standard medical care who underwent CT-guided percutaneous catheter drainage with 12- to 22-French catheters. " 05/01/2007 - "Acute necrotizing pancreatitis: role of CT-guided percutaneous catheter drainage."
5.	Intravenous Infusions 01/01/2006 - "The aim of the study was to estimate the efficacy of piperacillin/tazobactam penetration into pancreatic necrosis in patients who received intravenous infusion of piperacillin/tazobactam at a dose of 4.5 g every 8 h for 14-21 days, as the prophylaxis in the treatment of acute necrotizing pancreatitis. "