Matrix Metalloproteinase 3 (Stromelysin 1)

An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)

Also Known As:

Networked: 343 relevant articles (3 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Garnero, Patrick: 4 articles (12/2011 - 01/2002)
2.	Radisky, Derek C: 3 articles (10/2011 - 07/2005)
3.	Biondi, Maria Luisa: 3 articles (03/2008 - 01/2002)
4.	Campbell, Megan N: 2 articles (05/2014 - 10/2011)
5.	Young, Scott K: 2 articles (05/2014 - 10/2011)
6.	Dolgonos, Lior: 2 articles (05/2014 - 10/2011)
7.	Zemans, Rachel L: 2 articles (05/2014 - 10/2011)
8.	Downey, Gregory P: 2 articles (05/2014 - 10/2011)
9.	Riches, David W H: 2 articles (05/2014 - 10/2011)
10.	McCulloch, Christopher A G: 2 articles (05/2014 - 10/2011)

Related Diseases

1.	Rheumatoid Arthritis 04/01/2012 - "Treating to target matrix metalloproteinase 3 normalisation together with disease activity score below 2.6 yields better effects than each alone in rheumatoid arthritis patients: T-4 Study." 03/01/1990 - "We identified the cells synthesizing stromelysin to be synovial cells in the synovial tissue from four biopsy cases with rheumatoid arthritis (RA) by in situ hybridization and immunohistochemical studies. " 03/01/2004 - "Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis." 04/01/2003 - "Possible role of shared epitope status in the relationship between matrix metalloproteinase 3 genotype and radiographic progression of rheumatoid arthritis: comment on the article by Constantin et al." 12/01/2000 - "To analyze the clinical significance of serial measurements of serum matrix metalloproteinase 3 (MMP-3) levels in relation to markers of disease activity and radiological progression in early rheumatoid arthritis (RA). "
2.	Shock 12/01/1996 - "Following heat shock stimulation, the stromelysin 1 transcript was up-regulated in U87 MG astrocytoma cells. " 06/01/1989 - "3 h of heat shock at a lower temperature (42 degrees C) is also effective in inducing collagenase and stromelysin mRNAs. " 06/01/1989 - "Our data suggest that heat shock may be an additional mechanism whereby collagenase and stromelysin are increased during rheumatoid arthritis and perhaps in other chronic inflammatory stress conditions." 06/01/1989 - "In addition, all-trans-retinoic acid, added just before heat shock, prevents the increase in mRNAs for collagenase and stromelysin. " 06/01/1989 - "Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin."
3.	Inflammation 10/20/1997 - "Our results suggest a novel role for beta 2-m in articular inflammation and destruction mediated by stromelysin in HAA." 06/01/1994 - "The stromelysin level in SF was thought to be a useful parameter of local joint involvement and that in serum of the severity of systemic joint inflammation." 07/01/1995 - "To evaluate the efficacy of stromelysin-1 (matrix metalloproteinase-3 [MMP-3]) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in serum as markers for joint inflammation in rheumatoid arthritis (RA). " 12/01/2000 - "These data suggest that genetic factors that predispose to reduced matrix remodeling (stromelysin 6A allele) and to increased inflammation (IL-6 G allele) combine to increase susceptibility for intima-media thickening in the carotid bifurcation, a predilection site for atherosclerosis." 05/01/2013 - "Surprisingly, ASIC-3(-/-) mice with CAIA demonstrated significantly increased joint inflammation, joint destruction, and expression of interleukin-6 (IL-6), matrix metalloproteinase 3 (MMP-3), and MMP-13 in joint tissue as compared to ASIC-3(+/+) mice. "
4.	Necrosis 01/01/1991 - "Transin-expressing hepatocytes were largely localized in areas subsequently eliminated by necrosis due to CCl4 intoxication. " 06/01/1997 - "Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy." 08/01/2005 - "Treatment resulted in increased numbers of CD4 cells infiltrating the colonic lamina propria, increased interferon gamma (IFN-gamma) levels, and increased transcripts for tumour necrosis factor alpha (TNF-alpha) and matrix metalloproteinase 3 (MMP3). " 04/01/2010 - "Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase 3." 10/01/1996 - "Medial femoral condyle were histologically processed, and the articular cartilage was stained for the presence of proteoglycans, stromelysin, tumor necrosis facto (TNF) alpha, and TNF receptors (p55 and p75). "
5.	Neoplasms (Cancer) 01/01/2011 - "There was no significant association between grade and expression of p53 and stromelysin in cancer tissue. " 01/01/2011 - "Subsequently, cancer tissue was processed, endolymphatic, intravascular and peritoneal invasion determined and CK-7, CK-20, stromelysin, Ki-67 and p53 expression evaluated. " 10/01/2004 - "Elevated expression of matrix metalloproteinase-3 (MMP-3/stromelysin-1) is associated with a variety of tumor types, although its in vivo functional role remains unclear. " 05/16/2003 - "Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44." 08/01/2001 - "Loss of JunB activity enhances stromelysin 1 expression in a model of the epithelial-to-mesenchymal transition of mouse skin tumors."

Related Drugs and Biologics

1.	Collagenases (Collagenase)
2.	Matrix Metalloproteinases
3.	Matrix Metalloproteinase 9 (Gelatinase B)
4.	Messenger RNA (mRNA)
5.	Matrix Metalloproteinase 1 (Interstitial Collagenase)
6.	Matrix Metalloproteinase 2 (Gelatinase A)
7.	Matrix Metalloproteinase 3 (Stromelysin 1)
8.	Fibronectins (Fibronectin)
9.	Collagen Type IV (Type IV Collagen)
10.	Peroxidase (Myeloperoxidase)

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Exercise Therapy (Therapy, Exercise)
3.	Intravitreal Injections
4.	Bioreactors
5.	Heterologous Transplantation (Xenotransplantation)