Radiopharmaceuticals

Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)

Networked: 1019 relevant articles (54 outcomes, 108 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saji, Hideo: 9 articles (01/2014 - 07/2003)
2.	Anderson, Carolyn J: 8 articles (03/2014 - 10/2003)
3.	Schibli, Roger: 8 articles (01/2014 - 10/2006)
4.	Müller, Cristina: 7 articles (01/2014 - 10/2006)
5.	Ferro-Flores, Guillermina: 6 articles (06/2015 - 02/2003)
6.	Elsinga, Philip H: 6 articles (05/2015 - 02/2002)
7.	Signore, A: 6 articles (03/2015 - 01/2003)
8.	Hoffman, Timothy J: 6 articles (02/2015 - 03/2002)
9.	Rubello, Domenico: 6 articles (01/2014 - 05/2008)
10.	Mukai, Takahiro: 6 articles (01/2013 - 09/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "In early clinical studies of safety and efficacy of the most common bone-seeking radiopharmaceuticals in single administration there were not any preferences in overall survival but individual clinical cases with extraordinary tumor regression after radionuclide therapy were reported. " 12/15/2000 - "The gain in avidity resulting from multivalency along with an improved biological half-life makes the tetravalent construct an important reagent for cancer therapy and diagnosis in MAb-based radiopharmaceuticals." 06/01/1993 - "Thanks to the various available radiopharmaceuticals, the ability of the tracers to document specific functional aspects, the improved methods for visualization and quantitation of organ injury and the possibilities of physiological or pharmacological intervention, nuclear medicine gives the clinician potent tools for the monitoring of organ function at risk during cancer therapy. " 05/01/2000 - "Radiolabeled anti-EGFR MAbs would be more effective for tumor imaging in cancer patients than peptide-based radiopharmaceuticals such as hEGF, because they exhibit higher tumor uptake at only moderately lower tumor-to-blood ratios." 01/01/2007 - "Given the poor therapeutic benefit obtained with cytotoxic therapeutic agents and empirical radiopharmaceuticals, so far used only for neoadjuvant and adjuvant treatments of cancer, we have tried to develop Paul Ehrlich's 'chemotherapia specifica' for safe and effective therapy of cancers in cigarette smokers. "
2.	Pain (Aches) 11/01/2011 - "Other researchers suggest enhanced antitumoral effects using high-energy beta emitters and propose aggressive first-line treatment in the early disease stage instead of using these radiopharmaceuticals only in end-stage patients suffering intractable bone pain. " 08/01/2007 - "All radiopharmaceuticals were effective in pain palliation, without induction of severe side effects or significant differences in therapeutic efficacy or toxicity." 01/01/2005 - "Both radiopharmaceuticals were effective in pain palliation, without induction of severe side effects or significant differences in therapeutic efficacy or toxicity." 11/01/2005 - "Results of this study indicate that all evaluated radiopharmaceuticals were effective in pain palliation without induction of severe side effects. " 04/01/2014 - "All three radiopharmaceuticals were equally effective in pain relief. "
3.	Neoplasm Metastasis (Metastasis) 11/01/1996 - "Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. " 01/01/1983 - "We have investigated the clinical efficacy for the detection of bone metastases of two recently marketed bone-seeking radiopharmaceuticals, HDP and DPD, compared with traditionally used MDP. " 05/01/2015 - "Study of Bone Surface Absorbed Dose in Treatment of Bone Metastases via Selected Radiopharmaceuticals: Using MCNP4C Code and Available Experimental Data." 12/01/2014 - "A new bone-targeting radiopharmaceuticals using radium-223 is also promising, because a randomized trial showed an overall survival advantage of radium-223 in prostate patients with bone metastases. " 07/01/2007 - "This study simulates the dose delivery process to skeletal metastases by bone surface- and bone volume-seeking radiopharmaceuticals. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2008 - "Also, a summary is made of clinical studies that report on the detection of prostate cancer with GRPR targeted radiopharmaceuticals." 12/01/2015 - "In this review article, we review novel MRI, MRI/US, and PET radiopharmaceuticals which will offer insight into the future direction of imaging in prostate cancer. " 05/01/2015 - "The authors reviewed the current literature for articles relevant to metastatic prostate cancer, clinical radiopharmaceuticals, castrate-resistant prostate cancer and development of Radium-223 . " 11/01/2014 - "The properties of even further new PSMA PET radiopharmaceuticals can be of increasing importance for the diagnostic work-up of prostate cancer in all stages. " 11/01/2014 - "Recently, there are a variety of molecular imaging paths and radiopharmaceuticals for the diagnosis and treatment of prostate cancer. "
5.	Breast Neoplasms (Breast Cancer) 03/01/2015 - "The new E3S probe can be used to study the OATP system and as a platform to create radiopharmaceuticals for imaging breast cancer." 04/01/2006 - "Finally we review work done with other radiopharmaceuticals beyond FDG designed to image a number of aspects of breast cancer biology, emphasizing those most likely to enter clinical trials in the near future." 03/01/2004 - "The aim of this study was to compare the success rate in lymphatic mapping and sentinel node biopsy in breast cancer using two radiopharmaceuticals. " 08/01/1998 - "The aim of this study was to assess the radiopharmaceuticals for breast cancer imaging in experimental mice implanted with breast cancer cells. " 03/01/2015 - "The use of Alpha-emitting radiopharmaceuticals in castrate-sensitive disease, in metastatic asymptomatic CRPC, the categorical sequencing amongst other treatments for CRPC, as well as the application to other primary pathologies, such as metastatic breast cancer, is currently evolving."

Related Drugs and Biologics

1.	Biological Markers (Surrogate Marker)
2.	Octreotide (Sandostatin)
3.	Somatostatin Receptors (Somatostatin Receptor)
4.	Somatostatin (Somatotropin Release-Inhibiting Factor)
5.	Estrogens (Estrogen)
6.	Pentetic Acid (DTPA)
7.	Strontium
8.	Amino Acids
9.	EDDA (NiEDDA)
10.	alpha-glucoheptonic acid (calcium glucoheptonate)

Related Therapies and Procedures

1.	Gamma Cameras (Gamma Camera)
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Castration
5.	Stem Cell Transplantation