Dietary Iron

Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.

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Networked: 414 relevant articles (12 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nemeth, Elizabeta: 9 articles (10/2015 - 02/2005)
2.	Kew, Michael C: 7 articles (03/2014 - 01/2006)
3.	Zimmermann, Michael B: 6 articles (12/2015 - 10/2008)
4.	Hurrell, Richard F: 6 articles (03/2015 - 09/2007)
5.	Ganz, Tomas: 5 articles (10/2015 - 02/2005)
6.	Tjalsma, Harold: 5 articles (09/2015 - 12/2010)
7.	Cross, Amanda J: 5 articles (06/2014 - 06/2006)
8.	Gabayan, Victoria: 4 articles (10/2015 - 02/2005)
9.	Iwasaku, Toshihiro: 4 articles (06/2015 - 06/2013)
10.	Okuhara, Yoshitaka: 4 articles (06/2015 - 06/2013)

Related Diseases

1.	Anemia 02/01/2000 - "Results show that there was a change in knowledge about anemia and improved dietary iron intake in the 71 girls who completed the study compared with the 66 girls in the control group. " 11/01/2015 - "Heterozygous mice exhibited reduced erythrocyte volume and density, a phenotype consistent with dietary iron deficiency anemia. " 01/01/2014 - "We found that mTORC1 activity in RBCs is regulated by dietary iron and that genetic activation or inhibition of mTORC1 results in macrocytic or microcytic anemia, respectively. " 01/01/2013 - "DSS-treated mice developed anemia that was not alleviated by dietary iron supplementation. " 09/01/2011 - "To assess the relative validity of food frequency questionnaire (FFQ) for estimating dietary iron and its related nutrients and food intakes of students with anemia. "
2.	Iron Overload 10/01/2015 - "Considering that phenotype related to iron overload associated with pathological conditions differs from that caused by dietary iron excess, our study set out to evaluate the impact of dietary iron restriction and dietary iron supplementation on oxidative stress and functional outcome in adult, healthy rats. " 10/01/2002 - "Recent studies of pedigrees suggest that, in addition to high dietary iron content, a genetic defect may also be implicated in iron overload in Africans. " 02/01/2002 - "The study population consisted of 150 black African adults, 90 of whom were at risk of iron overload on the basis of high dietary iron content in the form of traditional beer. " 09/15/1996 - "In the present study, we used a rat model of long term dietary iron supplementation to identify stellate cell genes that are expressed during chronic hepatic iron overload. " 07/01/2013 - "Iron overload caused by hereditary mutations or excess dietary iron uptake has been identified as a risk factor for CRC. "
3.	Neoplasms (Cancer) 01/10/2011 - "The potential genotoxicity of dietary iron has been seldom studied in human leukocyte and only few reports have investigated in human colon tumor cells. " 11/01/2005 - "No relation was found between dietary iron intake and risk of all cancer sites combined for either men or women. " 01/01/2004 - "Our results suggest that, following carcinogen exposure, elevated dietary iron promotes the growth of tumors with altered cellular homeostasis through a mechanism that is independent of oxidative stress." 11/15/1999 - "The effects of dietary iron overload on fumonisin B1-induced cancer promotion in the rat liver." 01/01/1995 - "These results suggest that dietary iron stimulates spontaneous lung tumor promotion in A/J mice, partly due to the enhancement of oxidative damage to the pulmonary nuclei."
4.	Inflammation 01/01/2013 - "Dietary iron and colonic inflammation synergistically activated colonic IL-6/IL-11-Stat3 signaling promoting tumorigenesis. " 01/01/2013 - "Chronic intestinal inflammation and high dietary iron are associated with colorectal cancer development. " 01/01/2013 - "Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice." 05/01/2011 - "This increased risk of ID may be due to the effects of obesity-related inflammation on dietary iron absorption. " 12/01/2015 - "This deficiency may be due to adiposity-related inflammation that increases serum hepcidin and decreases dietary iron absorption. "
5.	Insulin Resistance 06/15/2015 - "Insulin resistance due to dietary iron overload disrupts inner hair cell ribbon synapse plasticity in male mice." 06/01/2013 - "Dietary iron overload induces visceral adipose tissue insulin resistance." 06/15/2015 - "To evaluate whether cochlear inner hair cells (IHCs) ribbon synapse plasticity would be interrupted by insulin resistance (IR) due to dietary iron overload, we established an IR model in C57Bl/6 male mice with an iron-enriched diet for 16 weeks. " 04/28/2010 - "In order to ameliorate HCV-associated insulin resistance and its complications, the efficacy of the following interventions is discussed: a late evening snack, coffee consumption, dietary iron restriction, phlebotomy, and zinc supplements. " 06/01/2013 - "The aim of this study was to assess the effect of dietary iron supplementation on insulin resistance and the role of hepcidin in C57Bl/6 male mice fed a standard or iron-enriched diet for 16 weeks. "

Related Drugs and Biologics

1.	Iron
2.	hepcidin
3.	Zinc
4.	Ascorbic Acid (Vitamin C)
5.	Phenobarbital (Luminal)
6.	Coffee
7.	2,4-dinitrofluorobenzene sulfonic acid
8.	Ferritins (Ferritin)
9.	Heme (Haem)
10.	Transferrin (beta 2 Transferrin)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Blood Transfusion (Blood Transfusions)
3.	Injections
4.	Bariatric Surgery
5.	Vegetarian Diet (Vegetarianism)