Cadmium Chloride (Cadmium Dichloride)

A cadmium halide in the form of colorless crystals, soluble in water, methanol, and ethanol. It is used in photography, in dyeing, and calico printing, and as a solution to precipitate sulfides. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Also Known As:

Networked: 463 relevant articles (6 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Heikkila, John J: 5 articles (11/2014 - 10/2006)
2.	Fotakis, George: 5 articles (11/2006 - 06/2005)
3.	Timbrell, John A: 5 articles (11/2006 - 06/2005)
4.	Sil, Parames C: 3 articles (01/2009 - 07/2008)
5.	Sinha, Mahua: 3 articles (01/2009 - 07/2008)
6.	Manna, Prasenjit: 3 articles (01/2009 - 07/2008)
7.	Sultana, Sarwat: 3 articles (01/2006 - 01/2005)
8.	Prasad, Lakshmi: 3 articles (01/2006 - 01/2005)
9.	Khan, Tajdar Husain: 3 articles (01/2006 - 01/2005)
10.	Jahangir, Tamanna: 3 articles (01/2006 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2001 - "BALB/c-3T3 cells transformed with cadmium chloride were subcutaneously injected into nude mice to develop tumors and the cell lines derived from these tumors were used in the present study. " 02/01/1994 - "In previous studies cadmium chloride (CdCl2) nonlethally inhibited Y-1 mouse adrenal tumor cell 20-dihydroxyprogesterone (20DHP) secretion, affecting unstimulated and stimulated steroidogenic pathway sites differently. " 05/01/1987 - "During a 2-yr study of carcinogenesis by CdCl2 in male Wistar [Crl:(WI)BR] rats, weekly clinical observations during the last 6 mo of the study revealed many cases of persistent tumor-like masses at the site of the metal identification tags in the ears of the animals. " 06/01/2001 - "As in the case of the tumor cells, treating the nontransformed cells with the various modulators prior to their exposure to cadmium chloride resulted in inhibition in the expression of the proto-oncogenes. " 07/01/1999 - "Our findings suggest that increased GSH biosynthesis in CDDP-resistant cancer cells may be involved in the attenuation of HSF activation by CdCl2."
2.	Chromosome Aberrations (Chromosome Abnormalities) 11/01/2005 - "In this study, we investigated the genotoxic and cytotoxic potential of cadmium chloride (CdCl2) in Wistar rat tibia bone marrow cells, using the structural chromosomal aberration (SCA) and micronucleus (MN) test systems. " 11/01/2005 - "A study on the investigation of cadmium chloride genotoxicity in rat bone marrow using micronucleus test and chromosome aberration analysis." 01/01/2001 - "0.8 mcg/gm of bw), and assessed for the genotoxic effects through such studies as chromosome aberrations (CA), micronucleated erythrocytes (MNE), mitotic index (MI) and sperm head anomaly (SHA), keeping suitable succussed alcohol fed (positive) and CdCl2 untreated normal (negative) controls. " 11/01/2000 - "In this study we report the results of cytogenetic tests, namely a search for chromosome aberrations (CA) and sister chromatid exchanges (SCEs), performed on human amniotic fluid cells cultured and treated with Cadmium chloride. " 05/01/2000 - "In germ cells, chromosomal aberrations were observed in mouse spermatocytes 12 days post-treatment with the dose of 5.7 mg kg(-1) body wt. Moreover, a pronounced reduction in the number of spermatocytes was observed after administration of cadmium chloride (0.9, 1.9 and 5.7 mg kg(-1) body wt.) In in vitro studies, the three tested concentrations of 10, 15 and 20 microgram ml(-1) cadmium chloride induced a statistically significant increase in the frequency of SCEs in cultured mouse spleen cells. "
3.	Aneuploidy (Aneuploid) 08/21/2000 - "The frequency of aneuploid cells increased in all treatments with cadmium chloride. " 06/27/2001 - "Adaptive pretreatment with a nontoxic dose of cadmium chloride prior to challenge treatment with MNU reduced the frequency of chromatid type aberrations, micronuclei and aneuploid cells as well as the amount of DNA in comet tails of meristematic nuclei." 09/01/1990 - "We tested nine (cadmium chloride, chloral hydrate, colchicine, diazepam, econazole nitrate, hydroquinone, pyrimethamine, thiabendazole, thimerosal) of the 10 known or suspected spindle poisons of the coordinated programme to study aneuploidy induction sponsored by the Commission of the European Communities using Saccharomyces cerevisiae D61.M (mitotic chromosomal malsegregation system). " 05/01/1989 - "In the coordinated programme to study aneuploidy induction, sponsored by the Commission of the European Communities, 10 known or suspect spindle poisons (colchicine, econazole, chloralhydrate, hydroquinone, diazepam, thiabendazole, cadmium chloride, pyrimethamine, vincristine and thimerosal) were tested in mouse bone marrow cells for the induction of c-mitotic effects. " 05/01/1993 - "The synopsis of the in vivo test results in the first collaborative CEC Aneuploidy Project with 10 selected chemicals, colchicine (COL), econazole (EZ), chloral hydrate (CH), hydroquinone (HQ), diazepam (DZ), thiabendazole (TB), cadmium chloride (CD), thimerosal (TM), pyrimethamine (PY) and vinblastine (VBL), allowed several conclusions. "
4.	Prostatic Neoplasms (Prostate Cancer) 08/01/1992 - "The bases for this decision included: (1) a database for genotoxicity of cadmium with more negative test results than positive results and with most positive results in in vitro tests, indicating that cadmium has limited genotoxicity; (2) some epidemiologic evidence of respiratory tract cancer and prostatic cancer in people occupationally exposed to airborne cadmium but no reliable evidence of gastrointestinal tract cancers in workers; and (3) a large dietary oncogenicity study in rats of cadmium chloride at several dose levels, including a maximally tolerated dose (50 ppm) in males, which showed no increase of tumors due to cadmium ingestion in all of the 19 tissues examined. "
5.	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 08/01/1992 - "The bases for this decision included: (1) a database for genotoxicity of cadmium with more negative test results than positive results and with most positive results in in vitro tests, indicating that cadmium has limited genotoxicity; (2) some epidemiologic evidence of respiratory tract cancer and prostatic cancer in people occupationally exposed to airborne cadmium but no reliable evidence of gastrointestinal tract cancers in workers; and (3) a large dietary oncogenicity study in rats of cadmium chloride at several dose levels, including a maximally tolerated dose (50 ppm) in males, which showed no increase of tumors due to cadmium ingestion in all of the 19 tissues examined. "

Related Drugs and Biologics

1.	Cadmium
2.	DNA (Deoxyribonucleic Acid)
3.	Mercuric Chloride (Sublimate)
4.	Collagen
5.	Elastin
6.	Metallothionein
7.	sodium arsenite
8.	Colchicine
9.	Thimerosal (Thiomersal)
10.	Thiabendazole (Mintezol)

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Subcutaneous Injections
4.	Intraperitoneal Injections
5.	Intravenous Injections