NADPH Oxidase (NAD(P)H oxidase)

A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.

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Networked: 2686 relevant articles (71 outcomes, 311 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dusting, Gregory J: 24 articles (01/2015 - 07/2002)
2.	Shah, Ajay M: 22 articles (07/2015 - 01/2002)
3.	Holland, Steven M: 22 articles (02/2015 - 03/2002)
4.	Zalba, Guillermo: 21 articles (09/2015 - 08/2004)
5.	Segal, Brahm H: 21 articles (05/2014 - 03/2002)
6.	Holmdahl, Rikard: 20 articles (01/2016 - 01/2003)
7.	Roos, Dirk: 20 articles (12/2015 - 03/2003)
8.	Drummond, Grant R: 20 articles (01/2015 - 07/2002)
9.	Fortuño, Ana: 18 articles (09/2015 - 08/2004)
10.	Touyz, Rhian M: 18 articles (04/2015 - 12/2002)

Related Diseases

1.	Inflammation 09/21/2014 - "Our study revealed the importance of NADPH oxidase in the pathogenesis of both acute and chronic inflammation of the colon." 06/01/2013 - "In this study, we investigated the role of NADPH oxidase (NOX) in inflammation-mediated SN neurotoxicity. " 07/01/2012 - "Studies in CGD patients and CGD mouse models indicate that NADPH oxidase plays a key role in modulating inflammation and injury that is distinct from its antimicrobial function. " 05/21/2010 - "Macrophage disposal of cells at sites of inflammation is believed to play an important role in the resolution of the inflammatory process, and recent studies have suggested a role for the NADPH oxidase in the process of macrophage elimination of activated neutrophils. " 02/01/2010 - "The present study was set to identify possible priming agents for this enzyme and to test the hypothesis that the phagocytic NADPH oxidase contributes to OS and inflammation. "
2.	Fibrosis (Cirrhosis) 10/01/2013 - "AKF-PD attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signalling pathway, suggesting AKF-PD is a potential novel therapeutic agent against renal fibrosis." 09/02/2011 - "The aim of this study was to clarify the role of NOX1, a nonphagocytic form of NADPH oxidase, in the development of fibrosis using Nox1-deficient mice (Nox1KO). " 09/01/2007 - "Thus, our aims were to study the molecular and biochemical state of NADPH-oxidase in cirrhotic livers and to investigate its possible role in modulating hepatic vascular tone in cirrhosis. " 12/01/2015 - "NADPH oxidase mediates the effects of PM2.5 exposure on promoting hepatic fibrosis." 10/01/2015 - "Transforming growth factor-β1 (TGF-β1) stimulates the production of NADPH oxidase 4 (NOX4)-dependent ROS, promoting lung fibrosis (LF). "
3.	Insulin Resistance 07/01/2009 - "The aim of this study was to analyze the relationship of NADPH oxidase activation with insulin resistance, and the effect of this interaction on the cardiovascular risk in MetS patients. " 07/01/2014 - "FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress." 06/15/2014 - "We hypothesized that macrophages from mice lacking NOX2 (Cybb), an essential component of the NADPH oxidase complex highly expressed in immune cells and associated with their inflammatory response, would be less inflammatory and that these mice would be protected from the development of high-fat-induced insulin resistance. " 12/01/2013 - "Response to Comment on: Sukumar et al. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. " 12/01/2013 - "Comment on: Sukumar et al. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. "
4.	Cardiomegaly (Heart Hypertrophy) 07/01/2010 - "In the present study, we sought to determine whether inhibition of NADPH oxidase prevents cardiac hypertrophy. " 06/01/2015 - "Additionally, we find that T4-induced LV dysfunction is independent of cardiac hypertrophy and NADPH oxidase is a key player in this process. " 07/01/2010 - "Inhibition of NADPH oxidase and elimination of ROS may prevent or repair damage due to cardiac hypertrophy." 07/01/2010 - "In conclusion, local expression of Ang II appears to contribute to pressure overload-induced cardiac hypertrophy by upregulating NADPH oxidase expression and promoting ROS synthesis. " 07/01/2010 - "Accordingly, NADPH oxidase-dependent ROS may play a role in cardiac hypertrophy induced by pressure overload. "
5.	Hypertension (High Blood Pressure) 01/01/2015 - "The aim of the present study was to investigate PDI expression and NADPH oxidase dependent ROS generation during hypertension development. " 01/01/2014 - "This study demonstrates that genetic deficiency of ACE2 activity in mice fosters oxidative stress in the kidney in the absence of overt hypertension and is associated with reduced kidney capacity to hydrolyze Ang II. ACE2KO mice serve as a novel in vivo model to examine the role of overactivity of NADPH oxidase in kidney function. " 02/01/2012 - "The present study investigated the brain regional specificity of NADPH oxidase and the role of NOX2 and NOX4 NADPH oxidase subunits in the hypothalamic paraventricular nucleus (PVN) in Aldo/salt-induced hypertension. " 11/01/2007 - "The aim of our study was to test the hypothesis that PMNLs and that the PMNL-associated NADPH oxidase contribute to the development of hypertension in the Sabra rat model. " 04/01/2002 - "A lymphoblast model was used, as this has previously been used in the study of hypertension and of NADPH oxidase. "

Related Drugs and Biologics

1.	acetovanillone (apocynin)
2.	Superoxides (Superoxide)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	3-nitrotyrosine
5.	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)
6.	Nitric Oxide Synthase (NO Synthase)
7.	Antioxidants
8.	Insulin (Novolin)
9.	nebivolol
10.	Nitric Oxide (Nitrogen Monoxide)

Related Therapies and Procedures

1.	Ligation
2.	Resuscitation
3.	Endarterectomy (Thromboendarterectomy)
4.	Electrodes (Electrode)
5.	Aftercare (After-Treatment)