Troponin C

03/01/2013 - "The electrostatic interaction between residues E15 and E19 in troponin C and H162 in TnI at low pH is responsible for stabilizing the conformation of troponin C that leads to contraction, thus partially ablating the decreased Ca(2+)-sensitivity caused by acidosis."
01/01/1998 - "The decrease in the Ca2+ binding to troponin C explains the decrease in tetanic and twitch contraction, and mechanical stress applied to the preparation induced less [Ca2+]i change in acidosis."
01/01/1998 - "Acidosis decreased the normalized extra Ca2+ to [Ca2+]i immediately before the length change, which indicates that the amount of Ca2+ bound to troponin C is less when [Ca2+]i is the same as in the control. "
10/01/1993 - "Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice."
03/13/1989 - "Effect of acidosis on Ca2+ sensitivity of skinned cardiac muscle with troponin C exchange. "

08/01/2011 - "Cardiac troponin C (cTnC) is the Ca²⁺ dependent switch for contraction in heart muscle making it a potential target for drug research in the therapy of heart failure. "
08/23/2002 - "Cardiac troponin C (cTnC) is the Ca(2+)-dependent switch for contraction in heart muscle and a potential target for drugs in the therapy of heart failure. "
05/09/2000 - "Cardiac troponin C (cTnC) is the calcium-dependent switch for contraction in heart muscle and a potential target for drugs in the therapy of congestive heart failure. "
01/01/1995 - "Calcium sensitization via troponin-C: a new approach for the treatment of heart failure. "
10/25/2015 - "Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs."

01/14/2011 - "This spectroscopic study examined the steady-state and kinetic parameters governing the cross-bridge effect on the increased Ca(2+) affinity of hypertrophic cardiomyopathy-cardiac troponin C (HCM-cTnC) mutants. "
06/15/2010 - "In this study, we investigated the effects of hypertrophic cardiomyopathy-linked mutations A8V, E134D, and D145E in cardiac troponin C on the properties of the C-domain sites. "
11/01/2009 - "The present study investigates the effects of the first mutation of troponin C (hcTnC(L29Q)) found in a patient with hypertrophic cardiomyopathy (HCM) on force-pCa relations and the interplay with phosphorylation of sarcomeric PKA substrates. "
07/10/2009 - "A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy."
10/01/2015 - "In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene."

06/04/2010 - "In this study we explore the mechanisms by which a double mutation (E59D/D75Y) in cardiac troponin C (CTnC) associated with dilated cardiomyopathy reduces the Ca(2+)-activated maximal tension of cardiac muscle. "
01/01/2015 - "Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy."
04/01/2014 - "Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies."
09/30/2011 - "TNNC1, which encodes cardiac troponin C (cTnC), remains elusive as a dilated cardiomyopathy (DCM) gene. "
09/01/2009 - "Mutations of cardiac troponin C (cTnC) can cause dilated cardiomyopathy in humans. "

01/01/2012 - "Previous studies of cardiomyopathy-related mutations in cardiac troponin C (cTnC)-L29Q and G159D-have shown diverse findings. "
01/01/2012 - "Cardiomyopathy-Related Mutations in Cardiac Troponin C, L29Q and G159D, Have Divergent Effects on Rat Cardiac Myofiber Contractile Dynamics."
11/01/2010 - "Together, our results suggest that tnnc1a is required both for the function and structural integrity of the contractile machinery in cardiomyocytes, helping to clarify potential mechanisms of troponin C-mediated cardiomyopathy."
01/18/2008 - "Modulation of cardiac troponin C function by the cardiac-specific N-terminus of troponin I: influence of PKA phosphorylation and involvement in cardiomyopathies."
10/25/2015 - "Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs."