Gi-Go GTP-Binding Protein alpha Subunits (Gi alpha Subunit)

A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to inhibit ADENYLYL CYCLASES. Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.
Also Known As:
Gi alpha Subunit; GTP Binding Protein alpha Subunits, Gi Go; GTP-Binding Protein alpha Subunits, Gi-Go; G Protein Go; G Protein Subunit alphaoA; G Protein Subunit alphaoC; G(o) Protein; G(o1)alpha; G-Protein, Gi Subunit; G-Protein, Gi-Go Subunits; G-Protein, Go Subunit; G-Protein, Go1 Subunit; G-Protein, Inhibitory Go; GTP-Binding Protein alpha Subunit, Gi; GTP-Binding Protein alpha Subunit, Go; GTP-Binding Protein alpha Subunit, Go1; GTP-Binding Protein alpha Subunit, GoA; GTP-Binding Protein alpha Subunit, GoC; Gi-Alpha Protein; Gi-Go G-Proteins; Go Alpha Subunit; Guanine Nucleotide-Binding Protein Go; Ni Protein; Alpha Subunit, Go; G Protein, Gi Go Subunits; G Protein, Gi Go alpha Family; G Protein, Gi Subunit; G Protein, Go Subunit; G Protein, Go1 Subunit; G Protein, Inhibitory Gi; G Protein, Inhibitory Go; G-Proteins, Gi-Go; GTP Binding Protein alpha Subunit, Gi; GTP Binding Protein alpha Subunit, Go; GTP Binding Protein alpha Subunit, Go1; GTP Binding Protein alpha Subunit, GoA; GTP Binding Protein alpha Subunit, GoC; Gi Alpha Protein; Gi G-Protein, Inhibitory; Gi Go G Proteins; Gi Subunit G-Protein; Gi, Inhibitory G Protein; Gi-Go Subunits G-Protein; Go G-Protein, Inhibitory; Go Subunit G-Protein; Go, G Protein; Go1 Subunit G-Protein; Guanine Nucleotide Binding Protein Go; Inhibitory G-Protein Gi; Inhibitory Gi G-Protein; Inhibitory Go G-Protein; Subunit G-Protein, Gi; Subunit G-Protein, Go; Subunit G-Protein, Go1; Subunit, Gi alpha; Subunit, Go Alpha; Subunits G-Protein, Gi-Go; alpha Subunit, Gi; G-Protein, Gi-Go alpha Family; G-Protein, Inhibitory Gi; Gi, Inhibitory G-Protein
Networked: 38 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results


1. Kolev, Vesselin: 1 article (10/2020)
2. Mondal, Dibyendu: 1 article (10/2020)
3. Warshel, Arieh: 1 article (10/2020)
4. Badawy, Shaymaa Mohamed Mohadmed: 1 article (01/2017)
5. Hirai, Chihoko: 1 article (01/2017)
6. Kajimoto, Taketoshi: 1 article (01/2017)
7. Nakamura, Shun-Ichi: 1 article (01/2017)
8. Okada, Taro: 1 article (01/2017)
9. Zhang, Lifang: 1 article (01/2017)
10. Kuroda, Ryohei: 1 article (01/2015)

Related Diseases

1. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
2. Neuroblastoma
02/13/1989 - "Elevated levels of the guanine nucleotide binding protein, Go, are associated with differentiation of neuroblastoma x glioma hybrid cells."
01/01/2017 - "Treatment of human neuroblastoma cells with recombinant α-Syn caused S1P type 1 (S1P1) receptor-selective uncoupling from inhibitory G-protein (Gi) as determined by both functional and fluorescence resonance energy transfer (FRET)-based structural analyses. "
02/01/1992 - "We have previously identified two isoforms of Go alpha in membranes of N1E-115 neuroblastoma cells, using an antibody raised against the purified Go alpha subunit; one isoform of the Go alpha subunit (pI 5.80) is present in undifferentiated cells, whereas a more acidic isoform (pI 5.55) appears during differentiation [J. "
03/01/1993 - "Continuous elevation of intracellular cyclic AMP (cAMP) by culturing neuroblastoma x glioma NG108-15 hybrid cells in the presence of forskolin and isobutylmethylxanthine (IBMX) in a chemically defined medium resulted in differentiation of the hybrid cells, as indicated by extension of neurite-like structures and induction of a subclass of G-protein, Go, as monitored by Western analysis. "
11/01/1987 - "We have found that neuroendocrine tumors (including neuroblastoma, ganglioneuroma, gut carcinoid, pheochromocytoma, medullary thyroid carcinoma, insulinoma, glucagonoma, prolactinoma, carotid body tumor, and small cell lung carcinoma) produce considerable amounts (about 1000-80,000 ng/g tissue) of the alpha subunit of guanine nucleotide-binding protein, GO (GO alpha), whereas nonneuroendocrine tumors contain less than 300 ng of GO alpha/g tissue. "
3. Heart Failure
4. Schizophrenia (Dementia Praecox)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Antigens
2. Synaptophysin
3. Antibodies
4. Pertussis Toxin
5. Adenylyl Cyclases (Adenylyl Cyclase)
6. Proteins (Proteins, Gene)
7. GTP-Binding Proteins (G-Protein)
8. Opioid Receptors (Opioid Receptor)
9. Guanosine Triphosphate (GTP)
10. Presenilin-1

Related Therapies and Procedures

1. Therapeutics
2. Ligation