Gs GTP-Binding Protein alpha Subunits (G(s)alpha)

A family of heterotrimeric GTP-binding protein alpha subunits that activate ADENYLYL CYCLASES.

Also Known As:

G(s)alpha; GTP Binding Protein alpha Subunits, Gs; GTP-Binding Protein alpha Subunits, Gs; G(s), alpha Subunit; Gs Stimulatory G-Proteins; Gs alpha GTP-Binding Protein Subunits; Gs, Stimulatory G-Protein; Ns Protein, Regulatory; Stimulatory GTP-Binding Protein, alpha Subunit; alpha-Gs; G Protein, Gs alpha Family; G Protein, Stimulatory Gs; G-Protein Gs, Stimulatory; G-Proteins, Gs Stimulatory; Gs G-Protein, Stimulatory; Gs Stimulatory G Proteins; Gs alpha GTP Binding Protein Subunits; Gs, Stimulatory G Protein; Regulatory Ns Protein; Stimulatory G-Protein Gs; Stimulatory G-Proteins, Gs; Stimulatory GTP Binding Protein, alpha Subunit; Stimulatory Gs G-Protein; alpha Gs; G-Protein, Gs alpha Family; G-Protein, Stimulatory Gs

Networked: 105 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Weinstein, Lee S: 11 articles (09/2010 - 09/2003)
2.	Chen, Min: 8 articles (09/2010 - 12/2004)
3.	Xie, Tao: 6 articles (09/2010 - 12/2004)
4.	Gavrilova, Oksana: 5 articles (04/2010 - 05/2005)
5.	Liu, Jie: 4 articles (05/2008 - 09/2003)
6.	Gupta, Divakar: 3 articles (04/2010 - 04/2009)
7.	Lai, Edwin W: 3 articles (04/2010 - 05/2008)
8.	Wang, Jie: 3 articles (04/2010 - 04/2009)
9.	Weinstein, L S: 3 articles (01/2010 - 11/2000)
10.	Bonthron, D T: 3 articles (03/2001 - 03/2000)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/03/1999 - "Since the agents activating G(S)alpha-mediated signaling pathways have been shown to increase in vitro proliferation of prostate cancer cells, present studies examined the G(S)alpha-mediated signaling in tumorigenicity and invasiveness of PC-3M prostate cancer cells. " 06/03/1999 - "These results suggest that persistent activation of G(S)alpha-mediated signaling cascade can dramatically accelerate tumorigenesis and metastasizing ability of prostate cancer cells." 10/01/2004 - "Metafectene is superior to lipofectamine in the transfection of G(s) alpha prostate cancer cells." 10/01/2004 - "We used these agents to transfect two prostate cancer cell lines, PC3 and G(s) alpha, with a deoxyribonucleic acid (DNA) expression vector that generates double-stranded ribonucleic acid (RNA) for RNA interference (RNAi). "
2.	Heart Failure 03/01/2005 - "There was no association between the beta(2)-adrenergic receptor or G(s)alpha polymorphisms with decompensated heart failure. " 08/08/1996 - "Using both immunoblotting technique and the bacterial toxin-mediated ADP ribosylation assays, we found that the stimulatory G-protein (Gs) was reduced in both ventricles of the heart failure dogs. " 07/01/2004 - "Losartan and imidapril treatments improved cardiac function and attenuated alterations in mRNA levels for G(s)alpha and G(i)alpha proteins, as well as G(s)alpha activity, without affecting changes in AC protein content or activities in heart failure due to volume overload. "
3.	Pseudohypoparathyroidism 11/01/2000 - "Studies in patients with Albright hereditary osteodystrophy suggest a similar G(s)alpha imprinting pattern in humans. " 02/01/2010 - "Mutations affecting G(s)alpha coding exons of GNAS and epigenetic alterations in the same gene are associated with PHP-Ia and -Ib, respectively. " 05/01/2006 - "Pseudohypoparathyroidism (PHP) types Ia and Ic result from heterozygous inactivating mutations of Gs alpha, the alpha-subunit of the heterotrimeric stimulatory G-protein, Gs. " 12/01/2004 - "Imprinting of one differentially methylated region within GNAS is virtually always lost in pseudohypoparathyroidism type 1B, and this region is probably responsible for tissue-specific G(s)alpha imprinting. " 12/01/2004 - "Heterozygous inactivating G(s)alpha mutations lead to Albright hereditary osteodystrophy. "
4.	Neoplasms (Cancer) 01/01/2009 - "Molecular studies showed that the tumors were not associated with deletion of the wild-type allele, making it unlikely that these tumors resulted from homozygous loss of G(s)alpha. " 01/01/2018 - "ZIP9 acts through several signal transduction pathways, a stimulatory G protein (Gs) in granulosa cells, an inhibitory one (Gi) in cancer cells, and a Gq11 one (Gnα11) in spermatogenic cells. " 01/01/2009 - "We now describe the development of fibrous tumors in mice with heterozygous disruption of the Gnas gene, which encodes G(s)alpha and other gene products. " 03/01/2001 - "We further show that this monoallelic expression of G(s)alpha is frequently relaxed in somatotroph tumors, both in those that have gsp mutations and in those that do not. " 06/03/1999 - "Interestingly, expression of G(S)alpha-WT reduced the ability of PC-3M cells to form tumors in nude mice. "
5.	Thyroid Neoplasms (Thyroid Cancer) 11/01/1999 - "In this study, we analyzed hyperfunctioning thyroid adenomas from seven Brazilian patients for TSH receptor and G(s)alpha gene mutations. " 07/01/2002 - "Feline thyroid adenomas are in part associated with mutations in the G(s alpha) gene and not with polymorphisms found in the thyrotropin receptor." 11/01/1999 - "Activating mutations in the gene encoding the alpha subunit of the stimulatory G protein (Gs alpha), as well as activating mutations in the gene encoding thyrotropin receptor in hyperfunctioning thyroid adenomas, have been reported. " 12/01/1996 - "Activating mutations of the alpha subunit of the G protein G(s) (G(s)alpha) have been identified in thyroid adenomas and well-differentiated thyroid carcinomas. " 06/01/1996 - "Point mutations of the alpha-subunit of the stimulatory G protein (Gs alpha) (termed gsp) and the TSH receptor, leading to constitutive elevation of intracellular cAMP contents, have recently been described in autonomously functioning thyroid adenomas. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	Losartan (Cozaar)
4.	metafectene
5.	Lipofectamine
6.	imidapril
7.	Adenylyl Cyclases (Adenylyl Cyclase)
8.	Thyrotropin Receptors (Thyrotropin Receptor)
9.	Cholera Toxin
10.	Arginine (L-Arginine)

Related Therapies and Procedures

1.	Radiotherapy