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Gs GTP-Binding Protein alpha Subunits (G(s)alpha)

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A family of heterotrimeric GTP-binding protein alpha subunits that activate ADENYLATE CYCLASE.

Also Known As:

G(s)alpha; GTP Binding Protein alpha Subunits, Gs; GTP-Binding Protein alpha Subunits, Gs; G(s), alpha Subunit; Gs Stimulatory G-Proteins; Gs alpha GTP-Binding Protein Subunits; Gs, Stimulatory G-Protein; Ns Protein, Regulatory; Stimulatory GTP-Binding Protein, alpha Subunit; alpha-Gs; G Protein, Gs alpha Family; G Protein, Stimulatory Gs; G-Protein Gs, Stimulatory; G-Proteins, Gs Stimulatory; Gs G-Protein, Stimulatory; Gs Stimulatory G Proteins; Gs alpha GTP Binding Protein Subunits; Gs, Stimulatory G Protein; Regulatory Ns Protein; Stimulatory G-Protein Gs; Stimulatory G-Proteins, Gs; Stimulatory GTP Binding Protein, alpha Subunit; Stimulatory Gs G-Protein; alpha Gs; G-Protein, Gs alpha Family; G-Protein, Stimulatory Gs

Networked: 93 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Weinstein, Lee S: 11 articles (09/2010 - 09/2003)
2.	Chen, Min: 8 articles (09/2010 - 12/2004)
3.	Xie, Tao: 6 articles (09/2010 - 12/2004)
4.	Gavrilova, Oksana: 5 articles (04/2010 - 05/2005)
5.	Liu, Jie: 4 articles (05/2008 - 09/2003)
6.	Gupta, Divakar: 3 articles (04/2010 - 04/2009)
7.	Wang, Jie: 3 articles (04/2010 - 04/2009)
8.	Lai, Edwin W: 3 articles (04/2010 - 05/2008)
9.	Hayward, B E: 3 articles (03/2001 - 03/2000)
10.	Bonthron, D T: 3 articles (03/2001 - 03/2000)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/03/1999 - "Since the agents activating G(S)alpha-mediated signaling pathways have been shown to increase in vitro proliferation of prostate cancer cells, present studies examined the G(S)alpha-mediated signaling in tumorigenicity and invasiveness of PC-3M prostate cancer cells. " 06/03/1999 - "These results suggest that persistent activation of G(S)alpha-mediated signaling cascade can dramatically accelerate tumorigenesis and metastasizing ability of prostate cancer cells." 10/01/2004 - "Metafectene is superior to lipofectamine in the transfection of G(s) alpha prostate cancer cells." 10/01/2004 - "We used these agents to transfect two prostate cancer cell lines, PC3 and G(s) alpha, with a deoxyribonucleic acid (DNA) expression vector that generates double-stranded ribonucleic acid (RNA) for RNA interference (RNAi). "
2.	Heart Failure 03/01/2005 - "There was no association between the beta(2)-adrenergic receptor or G(s)alpha polymorphisms with decompensated heart failure. " 08/08/1996 - "Using both immunoblotting technique and the bacterial toxin-mediated ADP ribosylation assays, we found that the stimulatory G-protein (Gs) was reduced in both ventricles of the heart failure dogs. " 07/01/2004 - "Losartan and imidapril treatments improved cardiac function and attenuated alterations in mRNA levels for G(s)alpha and G(i)alpha proteins, as well as G(s)alpha activity, without affecting changes in AC protein content or activities in heart failure due to volume overload. "
3.	Adenoma (Adenomas) 11/01/1999 - "In this study, we analyzed hyperfunctioning thyroid adenomas from seven Brazilian patients for TSH receptor and G(s)alpha gene mutations. " 04/01/2009 - "Although these neoplasias are monoclonal in origin, mutations of GNAS1, the gene encoding the alpha subunit of the stimulatory G-protein, Gs, are the only mutational changes unequivocally associated with growth hormone (GH)-secreting adenomas. " 06/01/2007 - "To explore the role of G(s)alpha in GH-secreting adenomas, we obtained somatolactotroph GH4C1 cell lines by performing doxycycline-dependent conditional overexpression of the wild-type G(s)alpha protein and expression of the gsp oncogene. " 07/01/2002 - "Feline thyroid adenomas are in part associated with mutations in the G(s alpha) gene and not with polymorphisms found in the thyrotropin receptor." 06/01/2002 - "The pathogenesis of thyroid hyperfunctioning adenomas is still only partially understood and controversy exists about the frequency of gain-of-function mutations of the TSH receptor or G(s)alpha gene, which activate the cAMP pathway. "
4.	Neoplasms (Cancer) 01/01/2009 - "Molecular studies showed that the tumors were not associated with deletion of the wild-type allele, making it unlikely that these tumors resulted from homozygous loss of G(s)alpha. " 01/01/2009 - "We now describe the development of fibrous tumors in mice with heterozygous disruption of the Gnas gene, which encodes G(s)alpha and other gene products. " 03/01/2001 - "These findings imply a possible role for loss of G(s)alpha imprinting during pituitary somatotroph tumorigenesis and also suggest that G(s)alpha imprinting is regulated separately from that of the other GNAS1 products, NESP55 and XLalphas, imprinting of which is retained in these tumors." 03/01/2001 - "We further show that this monoallelic expression of G(s)alpha is frequently relaxed in somatotroph tumors, both in those that have gsp mutations and in those that do not. " 06/03/1999 - "Interestingly, expression of G(S)alpha-WT reduced the ability of PC-3M cells to form tumors in nude mice. "
5.	Glioma (Gliomas) 09/01/1999 - "Triton X-100 extracted more G(s alpha) in membranes prepared from antidepressant-treated C6 glioma cells than from control groups. " 06/15/1994 - "Neuroblastoma x glioma hybrid NG108-15 cells endogenously express at least three receptors which activate adenylate cyclase via the intermediacy of the stimulatory G-protein, Gs. " 09/01/1999 - "Treatment of C6 glioma cells and rats with antidepressant drugs increases the detergent extraction of G(s alpha) from plasma membrane." 04/01/1996 - "Membranes from rat C6 glioma cells, which express G s alpha but not G i alpha 1, responded to the addition of tubulin with a stable activation of adenyl cyclase. " 08/01/1998 - "On the cellular level, opioid dependence is characterized by a significant elevation of adenylyl cyclase (AC) activity after drug withdrawal, a regulatory phenomenon termed "AC supersensitivity" or "cAMP overshoot." The present study examines the role of the stimulatory G protein (Gs) in the expression of naloxone precipitated opioid withdrawal in chronically morphine (10 microM; 3 days) treated neuroblastoma X glioma (NG108-15) hybrid cells. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	Losartan (Cozaar)
4.	metafectene
5.	Lipofectamine
6.	imidapril
7.	Adenylate Cyclase (Adenylyl Cyclase)
8.	Thyrotropin Receptors (Thyrotropin Receptor)
9.	Adenosine Diphosphate (ADP)
10.	Cholera Toxin

Related Therapies and Procedures

1.	Radiotherapy