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GTP-Binding Proteins (G-Protein)

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Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.

Also Known As:

G-Protein; G Proteins; GTP-Binding Protein; Protein, GTP-Binding; GTP-Regulatory Protein; Guanine Nucleotide Coupling Protein; G Protein; GTP Binding Protein; GTP Binding Proteins; GTP Regulatory Protein; GTP Regulatory Proteins; Protein, GTP-Regulatory; Proteins, GTP-Binding; Proteins, GTP-Regulatory; G-Proteins; GTP-Regulatory Proteins; Guanine Nucleotide Regulatory Proteins

Networked: 5070 relevant articles (68 outcomes, 453 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Maggiolini, Marcello: 23 articles (10/2015 - 06/2004)
2.	Prossnitz, Eric R: 18 articles (05/2015 - 02/2007)
3.	Gutkind, J Silvio: 16 articles (11/2014 - 04/2004)
4.	Koch, Walter J: 15 articles (12/2015 - 11/2003)
5.	Siffert, Winfried: 15 articles (12/2014 - 02/2003)
6.	Wang, Ji Ming: 15 articles (11/2012 - 02/2004)
7.	Tripp, Ralph A: 14 articles (09/2015 - 12/2004)
8.	Okajima, Fumikazu: 14 articles (02/2015 - 10/2004)
9.	Vivacqua, Adele: 13 articles (06/2015 - 06/2004)
10.	Offermanns, Stefan: 12 articles (01/2016 - 10/2003)

Related Diseases

1.	Infection 12/01/1997 - "These results indicate that the G protein of BRSV can induce significant protection against BRSV infection in cattle, and that the BHV1/BRSV-G vaccine protects effectively against a subsequent BRSV and BHV1 infection." 11/03/2011 - "These results suggest that the LaSota recombinant virus is a safe and effective vaccine vector and that expression of the aMPV-C G protein alone is not sufficient to provide full protection against an aMPV-C infection. " 10/01/2013 - "The objectives of this study were: 1) to determine the transcriptional profiles of G-protein coupled receptor 18 (GPR18) in channel catfish after infection with Aeromonas hydrophila compared to that in healthy catfish; 2) to determine whether over-expression of GPR18 in catfish gill cells will offer protection against infection of A. hydrophila; 3) to determine whether recombinant pcDNA-GPR18 could be used as an immunostimulant to protect channel catfish against A. hydrophila infection. " 09/01/2010 - "This study shows that an anti-RSV G protein MAb might provide prophylaxis against both primary infection and FI-RSV-associated enhanced disease. " 02/01/2006 - "In this study, we show that expression of the RSV G protein or the G protein CX3C motif during infection is associated with reduced CX3CR1+ T cell trafficking to the lung, reduced frequencies of RSV-specific, MHC class I-restricted IFN-gamma-expressing cells, and lower numbers of IL-4- and CX3CL1-expressing cells. "
2.	Body Weight (Weight, Body) 04/01/1989 - "It was particularly significantly greater than that of the LP rats between week 3 and 5 where an important decrease was observed in this group (1.99 +/- 0.36 vs. 3.23 +/- 0.58 g body weight/g protein during the 1-3 weeks period). " 02/01/2014 - "Exercise trials differed only in the postexercise nutritional intervention: EX-FED (5 kcal, 0.83 g carbohydrate, 0.37 g protein, 0.03 g fat per kg body weight) and EX-FAST (noncaloric, isovolumic placebo) ingested immediately and one hour after exercise. " 08/01/2013 - "To help older people (>65 years) maintain and regain lean body mass and function, the PROT-AGE study group recommends average daily intake at least in the range of 1.0 to 1.2 g protein per kilogram of body weight per day. " 04/01/2009 - "In this study, 11 normal subjects consumed controlled oxalate diets containing 0.6, 1.2 and 1.8 g protein/kg body weight/day. " 01/01/1998 - "In a randomized crossover trial, the patients were given each diet (each containing 0.75 g protein and 32 kcal per kilogram body weight) for a 6-month period. "
3.	Neoplasms (Cancer) 09/01/1992 - "Direct sequencing of PCR reaction products identified the mutations as R201-H, R201-S and R201-C in exon 8 and Q227-L in exon 9. These results show the efficacy of PCR/SSCP analysis in the detection of G protein mutations and extend the generalization that these sites are hot spots in tumor-inducing mutations." 01/01/2015 - "Recent studies have shown that repression of regulator of G-protein signaling (RGS) 2 increases cancer cell growth. " 10/30/2014 - "In this study, we demonstrated that expression of the heterotrimeric G-protein alpha-12 (Gα12) is highly up-regulated in primary tumors and LN of OSCC patients, as assessed by quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC). " 06/01/2013 - "These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment." 03/01/2013 - "Future studies will now focus on defining how this G-protein-coupled receptor is coupled to the activation of p53, a tumor suppressor gene that is mutated in more than 50% of all human cancers."
4.	Hypertension (High Blood Pressure) 01/01/2016 - "This study aims to understand the role of procontractile G-protein-mediated signalling pathways in vascular smooth muscle in age-dependent hypertension. " 01/01/2013 - "The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. " 01/01/2011 - "In this study, we have investigated the potential role of the C825T, C1429T, and G5177A polymorphisms of the β3 subunit of G-proteins in essential hypertension in a group of Turkish subjects. " 01/01/2011 - "Several studies have demonstrated an association between G protein polymorphisms and essential hypertension in some populations, although contradictive results also exist. " 10/01/2010 - "Several studies examining the C825T polymorphism of the G protein β3 subunit (GNB3) have shown inconsistent results regarding susceptibility to hypertension. "
5.	Alzheimer Disease (Alzheimer's Disease) 11/01/1995 - "Previous studies examining the functional status of cortical muscarinic cholinergic M1 receptors have demonstrated an impairment in receptor-G protein coupling in Alzheimer's disease (AD) as measured by the inability of the receptor to form a high affinity agonist binding site. " 07/01/1991 - "The aim of this study was to establish whether the level of G alpha subunits of five G proteins was altered in Alzheimer's disease. " 07/01/1991 - "Robustness of G proteins in Alzheimer's disease: an immunoblot study." 07/01/2009 - "In this review, we discuss the role of this recently discovered G protein-coupled receptor in cognition and memory, particularly in Alzheimer's disease. " 05/01/2009 - "These results also suggest that specific antagonists of G-protein activity may have a therapeutic relevance in Alzheimer's disease."

Related Drugs and Biologics

1.	GTP-Binding Proteins (G-Protein)
2.	Calcium
3.	Glucose (Dextrose)
4.	Pertussis Toxin
5.	DNA (Deoxyribonucleic Acid)
6.	Messenger RNA (mRNA)
7.	Insulin (Novolin)
8.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
9.	Carbon Monoxide
10.	Angiotensin II

Related Therapies and Procedures

1.	Phototherapy (Light Therapy)
2.	Protein-Restricted Diet (Diet, Protein Restricted)
3.	Parenteral Nutrition
4.	Investigational Therapies (Experimental Therapy)
5.	Intraperitoneal Injections