Bioreactors (Bioreactor)

Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.

Also Known As:

Networked: 925 relevant articles (34 outcomes, 121 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Genzel, Yvonne: 10 articles (08/2022 - 04/2008)
2.	Reichl, Udo: 10 articles (08/2022 - 04/2008)
3.	Behie, Leo A: 10 articles (01/2013 - 03/2002)
4.	Sen, Arindom: 9 articles (01/2013 - 03/2002)
5.	Matsuura, Tomokazu: 8 articles (01/2017 - 09/2003)
6.	Jordan, Ingo: 6 articles (08/2022 - 01/2013)
7.	Mikos, Antonios G: 6 articles (12/2021 - 08/2015)
8.	Gerlach, Jörg C: 6 articles (07/2021 - 10/2003)
9.	Kamen, Amine A: 6 articles (01/2021 - 01/2005)
10.	Kumar, Ashok: 6 articles (01/2018 - 04/2011)

Related Diseases

1.	Liver Failure 06/14/2014 - "The efficacy of this novel bioreactor is promising for the study of liver failure." 12/01/1998 - "In the present study, we investigated the efficacy of the NWF bioreactor in a direct hemoperfusion experiment conducted to treat pigs with liver failure. " 04/01/2001 - "Efficacy of nonwoven fabric bioreactor immobilized with porcine hepatocytes for ex vivo xenogeneic perfusion treatment of liver failure in dogs." 12/01/1998 - "Efficacy of a bioreactor filled with porcine hepatocytes immobilized on nonwoven fabric for ex vivo direct hemoperfusion treatment of liver failure in pigs." 01/01/2011 - "This study aims to evaluate the effectiveness of a hepatocyte bioreactor in the treatment of experimental post-hepatectomy liver failure. "
2.	Infections 03/01/2023 - "The optimal production condition was successfully scaled up to a 2000 L Single Use Bioreactor (SUB), producing a maximum virus titer of ∼1.0e+7 plaque forming units (PFU)/mL. Further process intensification and simplification, including growing Vero cells at 2 gs per liter (g/L) of Cytodex-1 Gamma microcarriers and eliminating the media exchange (MX) step prior to infection helped to increase virus productivity by ∼2-fold." 01/01/2023 - "The large-scale bioreactors controlled at 34°C during infection maintained a three-fold increase in productivity in the GSH elution, and excellent clearance of host cell and media impurities was observed across all batches. " 12/24/2022 - "The current study confirmed that the utilization of Schott flasks and a benchtop bioreactor under the conditions applied herein are equivalent regarding the cell death kinetics corresponding to the recombinant baculovirus infection process in Sf9 cells. " 11/16/2023 - "Hence, optimal conditions for efficient S1RBD production were identified: MOI 3; cell density at infection 2-3 × 106 cells/mL; and time post-infection (tPI or harvest time) of 72 h and 72-96 h, successively, for expression in shake flasks and a 7L bioreactor. " 01/01/2023 - "Additionally, it is critical for establishing the time of infection in bioreactors and monitoring cell culture response to targeted infection over time. "
3.	Acute Liver Failure (Fulminant Hepatic Failure) 08/01/2003 - "The results obtained indicate that the bioreactor containing small liver fragments is effective in the treatment of acute hepatic failure in animals." 09/01/2003 - "The objective of this study was to evaluate the feasibility and safety of a hybrid liver support system with extracorporeal plasma separation and bioreactor perfusion in patients with acute liver failure (ALF) who had already fulfilled the criteria for high urgency liver transplantation (LTx). " 04/01/1999 - "AIM:To establish an extracorporeal bioartificial liver support system (EBLSS) using cultured human liver cells and to study its support effect for fulminant hepatic failure (FHF).METHODS:The liver support experiment of EBLSS consisting of aggregates cultured human liver cells, hollow fiber bioreactor, and circulation unit was carried out in dizhepatic dogs.RESULTS:The viability of isolated hepatocytes and nonparenchymal liver cells reached 96%. " 07/23/2021 - "Liver cells cultured in 3D bioreactors is an interesting option for temporary extracorporeal liver support in the treatment of acute liver failure and for animal models for preclinical drug screening. " 01/01/2018 - "Acute liver failure (ALF) plasma has cytotoxic effects on the cell-loaded bioreactor in bioartificial liver support systems due to the presence of innumerable hepatotoxic compounds that adversely affect the morphology and functionality of the cells. "
4.	Neoplasms (Cancer) 01/01/2021 - "The functional liver bioreactor, comprising hepatocytes and non-parenchymal cells in a 3D microperfused culture format, mimics the dormant-emergent metastatic progression observed in human patients: (a) a subpopulation of cancer cells spontaneously enter dormancy, (b) cycling cells are eliminated by standard chemotherapies, while quiescent dormant cells remain, and (c) chemoresistant dormant cells can be stimulated to emerge. " 01/01/2021 - "In this study, an array of miniaturized bioreactors has been developed to model tumor-immune interactions. " 05/01/2020 - "Compared to the so far reported alternatives with insulated electrodes, the here developed thermoplastic microfluidic bioreactors with uninsulated electrodes provide a new, versatile, and durable platform for in vitro cell studies toward the improvement of anti-cancer therapies including personalized treatment." 05/01/2020 - "Thermoplastic microfluidic bioreactors with integrated electrodes to study tumor treating fields on yeast cells." 11/26/2018 - "Herein, we describe a novel in vitro platform to study bone-tumor interactions based on three-dimensional co-culture of osteogenically enhanced human mesenchymal stem cells (OEhMSCs) in a rotating wall vessel bioreactor (RWV) while attached to micro-carrier beads coated with extracellular matrix (ECM) composed of factors found in anabolic bone tissue. "
5.	Inflammation (Inflammations) 01/01/2022 - "This study investigates how the interplay between biophysical and biochemical microenvironment cues influence phenotypic responses, including inflammation signatures, of primary human hepatocytes (PHH) cultured in a commercially available perfused bioreactor. " 02/26/2020 - "The catheters reduced viability of Staphylococcus aureus in long-term studies (7 d in a CDC bioreactor) and inflammation in the 7 d rabbit model. " 02/01/2020 - "This study showed that the ES bioreactor with LCP electrodes could enhance bone regeneration at large bone defects, where LCP can act as a mechanically resistant outer box without inflammation. " 05/01/2012 - "When the pellets were cultured in a bioreactor with inflammation, the BCP made 25% more GAGs per cell than the MSC and 57% more than the NPC (P < 0.05). " 05/01/2008 - "Reconstructing the signaling network regulating shear-induced COX-2 expression and inflammation may provide insights to optimize conditions for culturing artificial cartilage in bioreactors and for developing therapeutic interventions for arthritic disorders."

Related Drugs and Biologics

1.	Vaccines
2.	Enzymes
3.	Glucose (Dextrose)
4.	Alginates
5.	Antigens
6.	Peptides (Polypeptides)
7.	Immunoglobulins (Immunoglobulin)
8.	galactitol 2-dehydrogenase
9.	Oxygen (Dioxygen)
10.	Cryogels

Related Therapies and Procedures

1.	Artificial Liver (Bioartificial Liver)
2.	Transplantation
3.	Hemoperfusion
4.	Drug Therapy (Chemotherapy)
5.	Limb Salvage