Selectins

Family of cell adhesion molecules consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable number of domains that encode proteins homologous to complement-binding proteins. Selectins mediate the binding of leukocytes to the vascular endothelium. (From Dorland, 28th ed)

Networked: 565 relevant articles (11 outcomes, 59 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Borsig, Lubor: 13 articles (02/2014 - 09/2003)
2.	Konstantopoulos, Konstantinos: 10 articles (09/2015 - 02/2006)
3.	McEver, Rodger P: 7 articles (08/2015 - 02/2005)
4.	Sato, Shinichi: 6 articles (11/2011 - 05/2003)
5.	Witz, Isaac P: 6 articles (10/2008 - 09/2004)
6.	Kannagi, Reiji: 6 articles (08/2008 - 07/2002)
7.	Schumacher, Udo: 5 articles (04/2014 - 08/2012)
8.	Wicklein, Daniel: 5 articles (04/2014 - 08/2012)
9.	Schnaar, Ronald L: 5 articles (03/2009 - 02/2006)
10.	Takehara, Kazuhiko: 5 articles (09/2007 - 05/2003)

Related Diseases

1.	Inflammation 11/01/2003 - "Studies in several models of inflammation have underscored the importance of P- and E-selectins in the migration of T cells to inflamed tissues. " 12/01/1998 - "These studies indicate that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation." 10/01/1998 - "Recent studies have indicated that selectins (E,L,P) are implicated in cell trafficking, an important aspect of inflammation-related process. " 02/15/1998 - "In this study, we wished to examine the function of both the platelet and endothelial selectins, P- and E-selectins, in mediating platelet-endothelial interactions during inflammation. " 12/05/2015 - "Novel therapies are in development that target selectins and iNKT cells to prevent or interrupt the vicious cycle of adhesion and inflammation. "
2.	Neoplasms (Cancer) 03/15/2009 - "This study reveals a role for selectins in NK cell recruitment to tumors and in regulation of effective tumor immunity." 12/01/2014 - "A correlation between selectins and tumor aggressiveness has been demonstrated in several reports. " 10/01/2013 - "We report herein that cancer-associated GAGs are differentially recognized by selectins according to their density of sulfation and the pH conditions of the binding. " 10/01/2013 - "Selectins are a family of carbohydrate receptors well depicted for their role in tumor cells extravasation. " 01/01/2011 - "Accumulated evidence indicates that selectins regulate adhesion of circulating cancer cells to the walls of blood vessels. "
3.	Colonic Neoplasms (Colon Cancer) 10/01/1995 - "In the present study, we examine the interactions of multiple colon cancer cell lines with all three selectins. " 11/27/1998 - "Therefore, it is assumed that SLeX-rich colon cancer cells could be easily adhered to the endothelial cells that express selectins. " 08/06/2012 - "This study was aimed at exploiting the interactions of cancer cells with selectins under flow to selectively kill captured colon cancer cells. " 05/01/2003 - "As sialyl Lewis X is a lignad of the selectin family, it has been proposed that sialyl Lewis X-rich colon cancer cells metastasize to the liver by adhesion to selectins on hepatic endothelial cells. " 03/01/1999 - "In colon cancer, venules distributed along the invasive margin correspond to these vessels, which express E-, and P-selectins, and ICAM-1. "
4.	Ischemia 07/01/2014 - "The aim of this study was to test the hypothesis that molecular imaging of selectins with myocardial contrast echocardiographic (MCE) molecular imaging could be used to detect recent brief ischemia in closed-chest nonhuman primates. " 01/01/2015 - "Microenviromental change after synthetic E-selectins interfere in ischemia-reperfusion in rats and its contribution to endogenetic/exogenous never stem cells." 04/01/2014 - "Two and 5 hours after ischemia has resolved, a persistent expression of these 2 selectins was detected. " 04/01/2014 - "A hallmark of ischemia/reperfusion is activation of endothelial cells leading to altered expression of molecular markers, including selectins. " 07/01/2002 - "Evidence shows that leukocyte recruitment into inflamed liver sinusoids does not require selectins, with one notable exception: ischemia-reperfusion (I/R). "
5.	Hypertension (High Blood Pressure) 09/10/2011 - "E-and P-selectins were increased in hypertension compared to controls [75(51) ng/mL versus 45(17) ng/mL, (p<0.0001) and 47(18) ng/mL versus 38(15) ng/mL, (p=0.049), respectively], as well as cytokine concentrations (p<0.0001). " 09/10/2011 - "To calculate the relationship of E and P selectins with immunological changes in essential hypertension. " 01/01/1998 - "Our data suggest that selectins may be useful as indicators of vascular damage in hypertension." 08/01/2005 - "Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes." 01/01/2004 - "[Selectins in the pathogenesis and diagnosis of early atherosclerotic changes in children and adolescents with risk factors (obesity, hypertension and diabetes)]."

Related Drugs and Biologics

1.	P-Selectin
2.	Monoclonal Antibodies
3.	fucoidan
4.	Lectins
5.	Galectins (Galectin)
6.	Mucins
7.	C-Type Lectins (C-Type Lectin)
8.	Phenobarbital (Luminal)
9.	Galectin 3 (LGALS3)
10.	Glycyrrhizic Acid (Glycyrrhizin)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Microbubbles
4.	Microspheres (Microsphere)
5.	Therapeutics