Vascular Neoplasms (Neoplasms, Vascular)

Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.

Also Known As:

Networked: 83 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Epithelioid Hemangioendothelioma
3.	Hemangioma (Angioma)
4.	Kaposi Sarcoma (Kaposi's Sarcoma)
5.	Hemangiosarcoma (Angiosarcoma)

Experts

1.	Fletcher, Christopher D M: 2 articles (12/2020 - 05/2017)
2.	Thway, Khin: 2 articles (03/2020 - 07/2015)
3.	Kutzner, Heinz: 2 articles (02/2013 - 02/2008)
4.	Requena, Luis: 2 articles (02/2013 - 02/2008)
5.	Bonar, Fiona: 1 article (05/2022)
6.	Cheah, Alison: 1 article (05/2022)
7.	Gill, Anthony J: 1 article (05/2022)
8.	Maclean, Fiona: 1 article (05/2022)
9.	Moir, Denis: 1 article (05/2022)
10.	Tabot, Joel: 1 article (05/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Neoplasms:

1.	ArgonIBA 11/10/1983 - "Nd: YAG and Argon lasers are more effective for coagulation of blood vessels and dealing with vascular neoplasms. " 01/01/1983 - "Nd:YAG and argon lasers are more effective for coagulation of blood vessels and for dealing with vascular neoplasms. "
2.	GadoliniumIBA 01/01/2006 - "Gadolinium provides useful information about new lesion activity and is helpful in ruling out alternative diagnoses such as neoplasm, vascular malformations, and leptomeningeal disease. "
3.	AntibodiesIBA 11/01/2004 - "The discrepancy between radioligand studies and previous immunohistochemical studies is attributable to the use of antibodies raised against ER alpha, which is not expressed in vascular lesions, and not ER beta, which is broadly expressed in both benign and malignant vascular neoplasms. " 11/01/2022 - "Herein, we review the differential diagnosis of epithelioid vascular neoplasms, with a focus on the cytomorphology, differential diagnoses, and ancillary studies that pathologists should be aware of when evaluating small biopsies and aspirates, including novel translocations, and associated monoclonal immunohistochemistry antibodies, that can help in the diagnosis of some of these tumors. "
4.	Proteins (Proteins, Gene)FDA Link 06/01/2018 - "Summary of expression of SPARC protein in cutaneous vascular neoplasms and mimickers." 05/01/2023 - "Epithelioid hemangioma is a benign vascular neoplasm associated with FOS and/or FOSB protein overexpression detected by immunohistochemistry (IHC). " 05/01/2004 - "In this study, a novel monoclonal antibody raised against the carboxyl terminal of the FLI-1 protein (clone GI146-222, BD Pharmingen) was tested in a series of small round cell and vascular neoplasms. " 07/01/2023 - "The purpose of this review is to summarize the available data related to superficially located benign and low-grade vascular neoplasms and to highlight recent molecular advances with the role of surrogate immunohistochemistry to target pathogenic proteins as diagnostic biomarkers."
5.	von Willebrand FactorIBA 05/01/2012 - "The diagnosis of vascular neoplasms is often facilitated by the use of immunohistochemical markers such as factor VIII-related antigen, CD31, and CD34. " 05/01/2012 - "Comparison of CD34, CD31, and factor VIII-related antigen immunohistochemical expression in feline vascular neoplasms and CD34 expression in feline nonvascular neoplasms." 06/01/1986 - "Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin." 06/01/1986 - "Markers for endothelial cells including Ulex europaeus 1 lectin, blood group A, B, and H, and the prostaglandin metabolite 6-keto-PGF1 alpha were evaluated in paraffin secretions from formalin-fixed benign and malignant vascular neoplasms using a variety of immunohistochemical techniques, and results compared with staining for factor VIII-related antigen. "
6.	Hematoxylin (Haematoxylon)IBA 01/01/2021 - "Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. " 03/01/2009 - "The histopathological examination of the biopsy specimens by hematoxylin and eosin method was not suggestive of a malignant vascular neoplasm initially and the differential diagnoses included carcinoma, malignant melanoma and atypical lymphoid infiltrate. "
7.	Eosine Yellowish-(YS) (Eosin)IBA 01/01/2021 - "Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. " 03/01/2009 - "The histopathological examination of the biopsy specimens by hematoxylin and eosin method was not suggestive of a malignant vascular neoplasm initially and the differential diagnoses included carcinoma, malignant melanoma and atypical lymphoid infiltrate. "
8.	Monoclonal AntibodiesIBA 05/01/2004 - "Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody." 06/01/1995 - "A monoclonal antibody against the endothelial cell adhesion molecule CD31 (endo-CAM, PECAM-1) was tested on wax embedded tissue of 56 cases of vascular lesions including benign and malignant vascular neoplasms. " 05/01/2004 - "A strong FLI-1 immunoreactivity was detected in all Ewing's sarcomas and vascular neoplasms, highlighting the high sensitivity of FLI-1 monoclonal antibody. " 05/01/2004 - "In this study, a novel monoclonal antibody raised against the carboxyl terminal of the FLI-1 protein (clone GI146-222, BD Pharmingen) was tested in a series of small round cell and vascular neoplasms. "
9.	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA 12/01/1999 - "The results of the current study show that although VEGFR-3 shows specificity toward lymphatics in normal tissues, this receptor is distributed extensively in benign and malignant vascular tumors and therefore can be considered a novel marker in the assessment of endothelial cell differentiation of vascular neoplasms."
10.	LectinsIBA 06/01/1986 - "Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin." 06/01/1986 - "Markers for endothelial cells including Ulex europaeus 1 lectin, blood group A, B, and H, and the prostaglandin metabolite 6-keto-PGF1 alpha were evaluated in paraffin secretions from formalin-fixed benign and malignant vascular neoplasms using a variety of immunohistochemical techniques, and results compared with staining for factor VIII-related antigen. "

Therapies and Procedures

1.	Lasers (Laser) 11/10/1983 - "Nd: YAG and Argon lasers are more effective for coagulation of blood vessels and dealing with vascular neoplasms. " 01/01/1983 - "Nd:YAG and argon lasers are more effective for coagulation of blood vessels and for dealing with vascular neoplasms. " 01/01/2022 - "The data of the laser emitters led to significantly higher (∼10 times) increase of the oxy-hemoglobin values in vascular neoplasms and much lower deoxy-hemoglobin values, if compared to the data obtained by the LED emitters. "
2.	Laser Therapy (Surgery, Laser) 01/01/2003 - "Laser therapy is a very useful adjunct in the management of these vascular neoplasms. " 11/01/2020 - "Angiokeratomas are benign vascular neoplasms that arise as solitary or multiple lesions, most commonly treated with excision, electrodessication, cryotherapy, or laser therapies. "
3.	Therapeutics 12/01/2012 - "The evaluation of increased mesenteric lymph node angiomas in rats for overall human safety risk assessment of novel pharmaceutical therapeutics should consider: genotoxicity of the test article, occurrence of vascular neoplasms in other locations in rats and in mice, occurrence of proliferative vascular lesions in nonclinical toxicology studies in non-rodent species, dose/exposure response, and pathophysiologic/morphologic differences and similarities of lymph node angiomas between rats and humans. " 10/01/1993 - "Giant vascular neoplasms in neonates generally require aggressive medical or surgical therapy for treatment of complications. " 03/01/1995 - "Pulsed dye laser therapy has revolutionized the treatment of benign vascular neoplasms of the skin. " 01/01/1992 - "Reporting two cases of dorsally located cervico-medullary hemangioblastomas the Authors discuss clinico-biological features, diagnosis and therapy of this vascular neoplasms, analyzing the cases reported in detail in the available literature. " 08/01/1999 - "Because the pathological composition of the lesion may resemble an angiosarcoma, understanding this benign vascular neoplasm is crucial so that an erroneous diagnosis of malignancy is not made and unnecessary adjuvant therapy is not given."
4.	Radiotherapy 10/01/2004 - "Radiosurgery and radiation therapy represent important but unique treatment paradigms for patients with certain neoplasms, vascular lesions, or functional disorders. " 01/01/2016 - "Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high-grade sarcomatous change found only in lesions with prior radiotherapy. " 06/01/2015 - "Thirty-five vascular neoplasms were reviewed from 21 breast cancer patients who received radiotherapy (AVL, n = 18; AS, n = 17). " 03/01/2002 - "In addition to "traditional" lymphatic neoplasms including lymphangioma circumscriptum, cavernous lymphangioma/cystic hygroma, benign lymphangioendothelioma, lymphangiomatosis and the rare lymphangiosarcoma, histological and immunohistochemical features of a group of vascular neoplasms with a hobnail cytomorphology (hobnail haemangioma, retiform haemangioendothelioma, papillary intralymphatic angioendothelioma, benign lymphangiomatous papule following radiotherapy) suggest that these lesions also belong to the spectrum of tumours of lymphatic vessels."
5.	Dye Lasers 03/01/1995 - "Pulsed dye laser therapy has revolutionized the treatment of benign vascular neoplasms of the skin. "