Muscle Neoplasms (Neoplasms, Muscle)

Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.

Also Known As:

Networked: 18 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia)
2.	Fibrosis (Cirrhosis)
3.	Cerebrovascular Disorders (Cerebrovascular Occlusion)
4.	Alveolar Rhabdomyosarcoma
5.	Neurodegenerative Diseases (Neurodegenerative Disease)

Experts

1.	Keller, Charles: 2 articles (08/2014 - 04/2011)
2.	Chung, Soonkyu: 1 article (01/2022)
3.	Duan, Bin: 1 article (01/2022)
4.	Kim, So-Youn: 1 article (01/2022)
5.	Kong, Yunfan: 1 article (01/2022)
6.	Kuss, Mitchell: 1 article (01/2022)
7.	Shi, Wen: 1 article (01/2022)
8.	Xue, Wen: 1 article (01/2022)
9.	Yu, Seok-Yeong: 1 article (01/2022)
10.	Alpert, Eric J: 1 article (10/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Muscle Neoplasms:

1.	Insulin-Like PeptidesIBA 04/01/2011 - "Inhibition of the insulin-like growth factor 1 receptor (Igf1r) is an approach being taken in clinical trials to overcome the dismal outcome for metastatic alveolar rhabdomyosarcoma (ARMS), an aggressive muscle cancer of children and young adults. "
2.	Proteins (Proteins, Gene)FDA Link 01/01/2021 - "In high-grade non-invasive muscle neoplasms, tumor cells showed weak expression for both HER2 and c-KIT proteins, but with progression to muscle-invasion, tumor cells strongly expressed HER2 and lost expression to c-KIT. " 02/01/2020 - "RASSF4, a member of the classical RASSF family of scaffold proteins, is associated with alveolar rhabdomyosarcoma, an aggressive pediatric cancer of muscle histogenesis. " 02/01/2010 - "The dysfunction of protein degradative pathways has been associated with the development of a number of important diseases including cancer, muscle wasting disorders and neurodegenerative diseases. " 03/15/2009 - "The demonstration that multiple inhibitory mechanisms can be suppressed and myogenic differentiation can be induced in the RD rhabdomyosarcomas by increasing the abundance of MyoD:E-protein heterodimers suggests a central integrating function that can be targeted to force differentiation in muscle cancer cells."
3.	AdipokinesIBA 01/01/2022 - "In response to CM induction, eWATs also secreted inflammatory adipokines related to the metastatic ability of cancer, muscle atrophy, and vascularization (NGAL, CD54, IGFBP-2, etc). "
4.	Selenoproteins (Selenoprotein)IBA 05/14/2018 - "Selenium insufficiency and polymorphisms or mutations in selenoproteins' genes and synthesis cofactors are involved in the pathophysiology of many diseases, including cardiovascular disorders, immune dysfunctions, cancer, muscle and bone disorders, endocrine functions and neurological disorders. "
5.	Proteasome Endopeptidase Complex (Proteasome)IBA 09/01/2013 - "The ubiquitin-proteasome system (UPS) plays a central role in maintaining protein homeostasis, emphasized by a myriad of diseases that are associated with altered UPS function such as cancer, muscle-wasting, and neurodegeneration. "
6.	Therapeutic UsesIBA 02/09/2021 - "A growing body of evidence has been identified potential therapeutic effects of creatine in a wide variety of clinical conditions, such as cancer, muscle dystrophy and neurodegenerative disorders. "
7.	SirtuinsIBA 03/06/2007 - "Recently, sirtuin are reported to have emerging pathogenetic roles in cancer, muscle differentiation, heart failure, neurodegeneration, diabetes and aging. "
8.	UbiquitinIBA 09/01/2013 - "The ubiquitin-proteasome system (UPS) plays a central role in maintaining protein homeostasis, emphasized by a myriad of diseases that are associated with altered UPS function such as cancer, muscle-wasting, and neurodegeneration. "
9.	Insulin-Like Growth Factor Binding Protein 2IBA 01/01/2022 - "In response to CM induction, eWATs also secreted inflammatory adipokines related to the metastatic ability of cancer, muscle atrophy, and vascularization (NGAL, CD54, IGFBP-2, etc). "
10.	Vitamin DFDA LinkGeneric 01/01/2018 - "In humans, observational data frequently demonstrate a link between poor vitamin D status and a large number of major human diseases such as cancer, muscle weakness and falls, infections or autoimmune diseases, hypertension and cardiovascular risks and events, obesity, diabetes and all aspects of the metabolic syndrome, and other health problems. "

Therapies and Procedures

1.	Tai Ji (Tai Chi Chuan) 01/01/2022 - "Twenty-one randomized controlled studies showed that Tai Chi significantly improved PSQI scores in patients with cancer, muscle fibrosis, and sub-health insomnia [MD = -1.16, 95% CI (-1.62, -0.71), P < 0.01]; There is insufficient evidence of improvement in patients with cerebrovascular disease [MD = -0.54, 95% CI (-1.58, 0.51), P = 0.31]; 8-form, 10-form or 24-form Yang's Taijiquan had the same effect in improving PSQI [MD = -1.33, 95% CI (-1.85, -0.81), P < 0.01]. "
2.	Therapeutics 08/11/2014 - "YAPping about differentiation therapy in muscle cancer." 08/11/2014 - "Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with molecularly-targeted differentiation therapies. "
3.	Immunotherapy 10/04/2021 - "We also established EGFR-targeted immunotherapies as a powerful approach to kill rhabdomyosarcoma muscle cancers, providing strong preclinical rationale for assessing a wider array of T cell immunotherapies in this disease."
4.	Drug Therapy (Chemotherapy) 08/11/2014 - "Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with molecularly-targeted differentiation therapies. "
5.	Denervation 01/01/1997 - "The signals activating this pathway include metabolic acidosis and glucocorticoids but must be more diverse since the pathway is also activated in response to starvation, sepsis, cancer, muscle denervation, thermal injury, and acute diabetes. "