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L-Selectin

Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.

Also Known As:

CD62L Antigen; L Selectin; LAM-1; Leu-8 Antigen; Leukocyte Adhesion Molecule, LAM-1; Mel-14 Antigen; TQ1 Antigen; Antigen, CD62L; Antigen, Leu-8; Antigen, Mel-14; Antigen, TQ1; Leu 8 Antigen; Leukocyte Adhesion Molecule, LAM 1; Mel 14 Antigen; Selectin, L; Antigens, CD62L; CD62L Antigens; LECAM-1

Networked: 869 relevant articles (29 outcomes, 119 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sato, Shinichi: 18 articles (03/2015 - 03/2002)
2.	Tedder, Thomas F: 17 articles (07/2014 - 03/2002)
3.	Borsig, Lubor: 14 articles (05/2014 - 02/2002)
4.	Takehara, Kazuhiko: 12 articles (07/2014 - 03/2002)
5.	Hasegawa, Minoru: 11 articles (07/2014 - 03/2002)
6.	Steeber, Douglas A: 11 articles (12/2009 - 03/2002)
7.	Fukuda, Minoru: 10 articles (06/2015 - 01/2004)
8.	Kawashima, Hiroto: 9 articles (06/2015 - 11/2002)
9.	Ley, Klaus: 9 articles (01/2015 - 04/2002)
10.	Yanaba, Koichi: 9 articles (04/2013 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 04/01/1998 - "Our results thus demonstrate that the purification of L-selectin- cells led to the generation of CD4 immune effector cells with unusually high therapeutic efficacy against chemically induced tumors. " 10/01/2000 - "The cytokine environment during the activation of tumor-draining lymph nodes can influence the therapeutic efficacy of activated L-selectin-, CD4+ T cells. " 10/01/2000 - "Therapeutic efficacy of Th1 and Th2 L-selectin--CD4+ tumor-reactive T cells." 04/01/1998 - "In adoptive immunotherapy of established intracranial MCA 205 tumors, L-selectin- cells displayed at least 30-fold greater therapeutic efficacy than unfractionated cells. " 01/01/2001 - "In mouse studies, the L-selectin(low) fraction of T cells in tumor-draining lymph nodes (TDLN) constitutes the potent pre-effector population and comprises both CD4+ and helper-independent CD8+ T cells. "
2.	Inflammation 01/01/2013 - "CST-deficiency ameliorates L-selectin-dependent monocyte infiltration in the renal interstitial inflammation, indicating that sulfatide is an endogenous ligand of L-selectin. " 04/01/2012 - "Recent studies indicated that the L-selectin-sulfated glycan interaction is also important for lymphocyte homing in chronic inflammation. " 04/01/1999 - "These studies show how in a defined extralymphoid tissue induction of endothelial L-selectin ligand depended not only on the presence or absence of an inflammatory state, but also on the nature of the inflammation." 09/01/1996 - "To study tissue expression of L-selectin, a leucocyte cell surface molecule that is considered to be involved in adhesion to certain endothelia, particularly in peripheral lymph nodes and during inflammation, and is shed upon leucocyte activation. " 01/01/1991 - "Antibody blocking studies in the mouse suggest that the MEL-14 antigen is involved in neutrophil-endothelial cell interactions and may be important in neutrophil extravasation to sites of inflammation in vivo. "
3.	Reperfusion Injury 10/01/1994 - "Thus, a humanized anti-L-selectin mAb appears to be an effective means of preserving the ischemic myocardium from reperfusion injury and of preserving myocardial contractile function, at least during the early reperfusion period." 11/01/2008 - "Taken together, these data suggest that the ability of NHE inhibitors such as HMA to reduce ischemia-reperfusion injury may be related to the nearly complete removal of L-selectin from the neutrophil surface." 04/01/2001 - "Our results indicate that LPS-induced protection of the heart from in vivo PMN-mediated ischemia/reperfusion injury may be due to decreased L-selectin expression of PMNs in LPS-treated animals." 04/01/2001 - "We have previously shown that a nonlethal dose of lipopolysaccharide (LPS) decreases L-selectin expression of neutrophils (PMNs), thereby preventing PMN-mediated reperfusion injury in the isolated heart. " 02/01/2001 - "These data suggest that PMNs from LPS-treated rats do not exacerbate ischemia-reperfusion injury as do control PMNs, possibly, due to impaired PMN adhesion to endothelium as a result of decreased L-selectin receptors."
4.	Neoplasm Metastasis (Metastasis) 01/01/2007 - "Here we provide evidence that the absence of both P- and L-selectin (PL -/- mice) dramatically improved survival in an experimental metastasis model. " 01/01/2007 - "We have previously shown that P- and L-selectin play independent roles in supporting the initial stages of hematogeneous metastasis. " 02/01/2006 - "Temporal inhibition of L-selectin by a function-blocking antibody reduced metastasis. " 02/01/2006 - "We previously showed that L-selectin deficiency also attenuates experimental metastasis. " 02/19/2002 - "Surprisingly, L-selectin expressed on endogenous leukocytes also facilitates metastasis in both the syngeneic and xenogeneic (T and B lymphocyte deficient) systems. "
5.	Necrosis 04/01/2006 - "Liver necrosis was more strongly inhibited in ICAM-1-/- mice than in L-selectin-/- mice but was most prominently reduced in L-selectin/ICAM-1-/- mice, in parallel with decreased plasma transaminase levels. " 10/01/1994 - "Humanized DREG-200 (2 mg/kg) administered 10 min before reperfusion significantly attenuated myocardial necrosis compared to an isotype-matched humanized control mAb (HuABL364) which does not bind to L-selectin (14 +/- 3 vs. 29 +/- 3% necrosis/area-at-risk, P < .01), representing a 52% reduction in myocardial necrosis. " 06/01/1996 - "Animals given the anti-L-selectin antibody demonstrated reduced immunohistochemical evidence of leukocyte accumulation at 24 hr postinjury but did not show improved wound perfusion or reduced tissue necrosis. " 06/01/1996 - "We sought to examine the role of L-selectin (CD62-L) and CD18 in leukocyte accumulation and tissue necrosis following burn injury. " 03/01/2007 - "The aim of this study is to evaluate the associations of diabetes with soluble L-selectin (sL-selectin) and tumour necrosis factor-alpha (TNF-alpha) in children with type 1 DM; and also to evaluate the associations of these parameters with the disease period, glycaemic control state and puberty stage. "

Related Drugs and Biologics

1.	P-Selectin
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	L-Selectin
4.	Ligands
5.	Monoclonal Antibodies
6.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
7.	fucoidan
8.	Antibodies
9.	Granulocyte Colony-Stimulating Factor (G-CSF)
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Renal Dialysis (Hemodialysis)
3.	Liver Transplantation
4.	Heart Transplantation (Grafting, Heart)
5.	Immunotherapy