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Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)

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Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.

Also Known As:

Glycoprotein Ib; CD42a Antigen; CD42b Antigen; CD42c Antigen; CD42d Antigen; Glycoprotein Ib alpha; Glycoprotein Ib beta; Glycoprotein Ib-IX Complex; Platelet Glycoprotein IX; Antigen, CD42a; Antigen, CD42b; Antigen, CD42c; Antigen, CD42d; Glycoprotein Ib IX Complex; Platelet Glycoprotein GPIb IX Complex; Antigens, CD42a; Antigens, CD42b; Antigens, CD42c; Antigens, CD42d; CD42a Antigens; CD42b Antigens; CD42c Antigens; CD42d Antigens; Platelet Membrane Glycoprotein IX; Platelet Membrane Glycoprotein Ib; Platelet Membrane Glycoprotein V

Networked: 217 relevant articles (3 outcomes, 8 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Deckmyn, Hans: 7 articles (05/2014 - 02/2002)
2.	Ware, Jerry: 5 articles (05/2014 - 05/2007)
3.	Berndt, Michael C: 5 articles (05/2013 - 01/2002)
4.	Du, Xiaoping: 4 articles (11/2013 - 05/2007)
5.	Denis, Cécile V: 3 articles (01/2015 - 01/2007)
6.	Lenting, Peter J: 3 articles (01/2015 - 01/2009)
7.	Russell, Susan: 3 articles (05/2014 - 05/2007)
8.	Heemskerk, Johan W M: 3 articles (04/2013 - 07/2004)
9.	Kleinschnitz, Christoph: 3 articles (10/2012 - 05/2007)
10.	Nieswandt, Bernhard: 3 articles (01/2011 - 07/2004)

Related Diseases

1.	Thrombocytopenia (Thrombopenia) 07/01/1999 - "Mean platelet volume, platelet distribution width, platelet-large cell ratio, membrane content of glycoprotein Ib and IIb-IIIa and platelet aggregation were significantly greater during resolution than during development of thrombocytopenia, suggesting a prevalence of young and old platelets respectively. " 01/01/2003 - "This mutation in the glycoprotein Ib (GPIb)-binding site has been found to increase the affinity of plasma VWF for platelets, and thus cause loss of HMW multimers and often thrombocytopenia. " 01/01/2015 - "Thrombocytopenia and increased platelet clearance observed in von Willebrand disease-type 2B (VWD-2B) may be explained by platelet apoptosis triggered by the constitutive binding of VWF to its receptor, glycoprotein Ib (GPIb). " 04/01/2014 - "Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage." 11/01/1999 - "Maternal immunization to glycoprotein IB/IX during pregnancy can cause severe fetal thrombocytopenia and massive intracranial bleeding."
2.	Thrombosis (Thrombus) 05/30/2013 - "LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis." 10/01/2008 - "The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons." 06/01/1994 - "We wished to determine whether blocking glycoprotein Ib receptors with a recombinant von Willibrand factor binding domain (VCL) increases the time required for thrombus formation after injury to the coronary arteries. " 09/01/1991 - "Reduction in thrombus formation by PG-1 F(ab')2, an anti-guinea pig platelet glycoprotein Ib monoclonal antibody." 04/01/2012 - "The impact of platelet membrane glycoprotein Ib alpha and Ia/IIa polymorphisms on the risk of thrombosis in the antiphospholipid syndrome."
3.	Acute Disease 09/01/2011 - "VWF antigen (VWF:Ag), platelet glycoprotein-Ib-α binding-conformation (GPIb-α/BC) and multimeric pattern were investigated in 74 patients with acquired TTP during acute disease, remission or both and 73 healthy controls. "
4.	Bernard-Soulier Syndrome (Giant Platelet Syndrome) 06/13/1988 - "We have, therefore, developed a sandwich-type enzyme-linked immunosorbent assay (ELISA) to study patients with the Bernard-Soulier syndrome (BSS), a hereditary platelet disorder characterized primarily, at the molecular level, by glycoprotein Ib (GpIb) deficiency. " 08/01/1987 - "A case of Bernard-Soulier syndrome: study of platelet glycoprotein Ib in a kindred." 09/01/2001 - "[A novel point mutation in the transmembrane domain of platelet glycoprotein IX gene identified in a Bernard-Soulier syndrome patient]." 01/01/2001 - "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome." 09/01/2000 - "Bernard-Soulier syndrome in a patient doubly heterozygous for two frameshift mutations in the glycoprotein ib alpha gene."
5.	Type 2 von Willebrand Disease 04/01/1992 - "We and others have recently identified a panel of missense mutations clustered in the platelet glycoprotein Ib binding domain of vWF from patients with type IIB von Willebrand disease. " 01/01/2015 - "Thrombocytopenia and increased platelet clearance observed in von Willebrand disease-type 2B (VWD-2B) may be explained by platelet apoptosis triggered by the constitutive binding of VWF to its receptor, glycoprotein Ib (GPIb). " 12/20/1993 - "Effect of type IIB von Willebrand disease mutation Arg(545)Cys on platelet glycoprotein Ib binding--studies with recombinant von Willebrand factor." 12/01/2013 - "von Willebrand disease type 2B (vWD-type 2B) is characterized by gain-of-function mutations in von Willebrand factor (vWF) that enhance its binding to the glycoprotein Ib-IX-V complex on platelets. " 06/01/2006 - "Type 2B von Willebrand disease (VWD) is characterised by an increased affinity of von Willebrand factor (VWF) for its platelet receptor glycoprotein Ib (GPIb). "

Related Drugs and Biologics

1.	von Willebrand Factor
2.	Antigens
3.	Aurintricarboxylic Acid
4.	abciximab (ReoPro)
5.	thymidine 5'-triphosphate (TTP)
6.	Leucine (L-Leucine)
7.	Autoantibodies
8.	Inosine Triphosphate (ITP)
9.	N-Acetylneuraminic Acid (Sialic Acid)
10.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass)
2.	Catheters
3.	Transplants (Transplant)
4.	Stents
5.	Intra-Arterial Infusions