Vitronectin Receptors

Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. They also bind FIBRINOGEN; VON WILLEBRAND FACTOR; osteopontin; and THROMBOSPONDINS.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cai, Yin Long: 1 article (07/2003)
2.	Honn, Kenneth V: 1 article (07/2003)
3.	Piasentin, Evano: 1 article (07/2003)
4.	Pidgeon, Graham P: 1 article (07/2003)
5.	Tang, Keqin: 1 article (07/2003)
6.	Chatterjee, A: 1 article (12/2001)
7.	Chattopadhyay, N: 1 article (12/2001)
8.	Dasgupta, S: 1 article (12/2001)
9.	Mitra, A: 1 article (12/2001)
10.	Ray, S: 1 article (12/2001)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/01/2001 - "In this present study, results obtained indicate that alphavbeta3 vitronectin receptors may play an important role in the malignant behaviour of human breast tumor. "
2.	Neoplasms (Cancer) 07/15/2003 - "The results show that 12-LOX regulates cell survival and apoptosis by affecting the expression and localization of the vitronectin receptors, alpha(v)beta(3) and alpha(v)beta(5), in two cancer cell lines." 10/01/1993 - "The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3. Cell interaction with vitronectin may induce spreading and migration and have an effect on cell growth and differentiation in specific processes, such as tumor growth and metastasis, wound healing, bone resorption and viral infection."
3.	Bone Resorption 02/15/1998 - "The CFU-O in both c-kithigh and c-kitlow populations showed key features of the osteoclast: multinucleated tartrate-resistant acid phosphatase-positive cell formation, expressions of vitronectin receptors, c-src and calcitonin receptors, and bone resorption. " 10/01/1993 - "The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3. Cell interaction with vitronectin may induce spreading and migration and have an effect on cell growth and differentiation in specific processes, such as tumor growth and metastasis, wound healing, bone resorption and viral infection."
4.	Giant Cell Tumor of Bone 01/01/1996 - "Multinucleated cells obtained from RA synovium expressed the osteoclast-specific phenotype such as tartrate-resistant acid phosphatase, carbonic anhydrase II, vacuolar proton-ATPase and vitronectin receptors at similar levels to those from a human giant cell tumor of bone. "
5.	Membranous Glomerulonephritis (Membranous Nephropathy) 01/01/1994 - "Thus, membranous nephropathy featured increased localization of vitronectin, C5b-9, and vitronectin receptors both within and around the subepithelial deposits, suggesting that the mechanism of immune complex disposal via the vitronectin receptor and the vitronectin-C5b-9 complex, associated with complement activation due to subepithelial immune complex formation, may also be active."

Related Drugs and Biologics

1.	Vitronectin
2.	Fibronectins (Fibronectin)
3.	Tartrate-Resistant Acid Phosphatase
4.	Transforming Growth Factor beta1 (TGF beta 1)
5.	Integrin beta3 (GPIIIa)
6.	Integrin alphaVbeta3
7.	Integrin alpha Chains
8.	Carbonic Anhydrase II
9.	Calcitonin Receptors (Calcitonin Receptor)
10.	Extracellular Matrix Proteins