fas Receptor (CD95 Antigen)

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.

Also Known As:

CD95 Antigen; Fas Cell Surface Death Receptor; TNFRSF6 Receptor; fas Antigen; APO 1 Antigen; Receptor, TNFRSF6; Receptor, fas; APO-1 Antigen; Antigens, CD95; CD95 Antigens; Receptors, fas; Tumor Necrosis Factor Receptor Superfamily, Member 6; fas Antigens; fas Receptors

Networked: 763 relevant articles (10 outcomes, 88 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Death Domain Receptors: 2368
        fas Receptor: 763
        APG101: 8
        human FAS protein
        mouse Fas protein
        rat Fas protein
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        fas Receptor: 763
        APG101: 8
        human FAS protein
        mouse Fas protein
        rat Fas protein

Experts

1.	Lee, Shin-Da: 6 articles (01/2022 - 10/2007)
2.	Abbasova, S G: 6 articles (11/2009 - 05/2000)
3.	Kushlinskii, N E: 6 articles (11/2009 - 05/2000)
4.	Zacks, David N: 5 articles (09/2019 - 12/2004)
5.	Jaeschke, Hartmut: 5 articles (08/2013 - 06/2002)
6.	Lipkin, V M: 5 articles (08/2002 - 05/2000)
7.	Huang, Chih-Yang: 4 articles (01/2022 - 10/2007)
8.	Fukuda, J: 4 articles (02/2004 - 07/2000)
9.	Haneji, T: 4 articles (02/2004 - 07/2000)
10.	Liu, Kebin: 3 articles (01/2022 - 11/2010)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2000 - "In vitro studies showed that the Fas receptor of thyroid tumor cells was functional, because apoptosis was induced by an agonistic Fas antibody. " 01/01/2022 - "Here we investigate the expression of mesenchymal-epithelial transition factor (c-Met) and Fas receptor in GSCs and their role in potentiating the tumor-mediated immune suppression through modulation of tumor infiltrating lymphocyte (TIL) population. " 01/01/2018 - "Treatment with an antagonist Fas receptor in A549 cell line or knocking out of the Fas gene in A549 cell line recovers tumor cells cycle and lessen neutrophils anti-tumor effect. " 09/01/2015 - "Condurango (Gonolobus condurango) Extract Activates Fas Receptor and Depolarizes Mitochondrial Membrane Potential to Induce ROS-dependent Apoptosis in Cancer Cells in vitro: CE-treatment on HeLa: a ROS-dependent mechanism." 01/15/2015 - "Among the many immunomodulatory and anti-tumor activities, IFN-γ up-regulates tumor cell death mediated by Fas receptor (FasR). "
2.	Hepatitis 06/01/1997 - "To evaluate the relationship between viral hepatitis and apoptosis, expression of Fas antigen in liver tissue sections of patients with viral hepatitis was investigated by immunohistochemical study using antibody to Fas antigen. " 09/01/2009 - "We report herein that MRL/Mp-Fas(lpr/lpr)-Sap(rpl/-) (MRL/lpr/rpl) mice lack Valpha14 NKT cells and are deficient in the Fas antigen but sensitive to Con A-induced hepatitis. " 10/01/2003 - "Apoptosis and its triggering molecule, Fas antigen, induce mechanisms that appear to be associated with the pathogenesis of chronic viral hepatitis." 10/01/2003 - "Fas antigen expression and apoptosis (apoptotic index) were assayed using flow cytometry in the hepatocytes of 27 patients with chronic viral hepatitis. " 10/01/2003 - "Fas antigen (CD95) expression and apoptosis in hepatocytes of patients with chronic viral hepatitis."
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/1997 - "Hence, in this preliminary report, we have demonstrated Fas receptor in human squamous cell carcinomas in vivo. " 01/01/1997 - "Fas receptor is expressed in human lung squamous cell carcinomas, whereas bcl-2 and apoptosis are not pronounced: a preliminary report." 01/01/1994 - "Using immunohistological, flow cytometry and electron microscopic analyses, we investigated the expression of Fas antigen on various skin tissues, and on cultured SV40-transformed human epidermal keratinocyte cell line KJD and human skin squamous cell carcinoma cell line HSC. " 07/01/2011 - "Fas receptor (CD95) & Fas ligand (CD178) expression in patients with tobacco-related intraoral squamous cell carcinoma." 01/01/2008 - "Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma."
4.	Sepsis (Septicemia) 04/01/2000 - "Fas receptor-deficient mice had no protection against sepsis-induced apoptosis in thymocytes or splenocytes. " 05/01/2017 - "Correlation of the expression of YY1 and Fas cell surface death receptor with apoptosis of peripheral blood mononuclear cells, and the development of multiple organ dysfunction in children with sepsis." 09/01/1996 - "Taken together, this study shows that measuring soluble Fas-receptor in myeloid leukemia is not diagnostically useful, but increased sCD95 may be associated with clinical complications like septicemias." 06/01/2004 - "The objective of the present study was to examine the levels of molecules associated with apoptosis belonging to the tumor necrosis factor (TNF)-alpha/TNF type-I receptor (TNFRI) and Fas ligand (FasL)/Fas receptor (Fas) pathways in patients with sepsis. " 03/01/1999 - "Thus, our study was to determine: 1) if polymicrobial sepsis (cecal ligation and puncture; CLP) alters thymocyte Fas antigen/receptor (Fas+) expression and 2) if the increase in Ao in septic ETX-sensitive C3H/HeN mice is seen in thymocytes from ETX-tolerant, C3H/HeJ, or the FasL-deficient/ETX-tolerant, C3H/HeJ-FasL(gld), male mouse strains subjected to CLP or sham-CLP (Sham) 12 or 24 h before they were killed. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 02/15/2018 - "Reverse transcription - polymerase chain reaction study revealed altered myocardial expressions of B-cell lymphoma gene-2, B-cell lymphoma - extra large, B-cell lymphoma-2 associated-x, Bcl - 2 associated death promoter, Fas-receptor and caspases-8,-9 and- 3 genes in myocardial infarcted rats. " 09/17/2014 - "Recently, CTLA4-FasL, that can bind to B7 and Fas receptor (Fas), was shown to induce robust apoptosis of cell lines originating from B cell lymphomas expressing both B7 and Fas, by activating pro-apoptotic signals in parallel to abrogating anti-apoptotic ones. " 12/01/1997 - "Expression of fas (CD95/APO-1) antigen induced by radiation therapy for diffuse B-cell lymphoma: immunohistochemical study." 08/01/2003 - "The FAS antigen (CD95/APO-1) is suggested to be a tumor suppressor gene since mice and patients with congenital FAS mutations are prone to B cell lymphomas and somatic FAS mutations are described in hematological and solid tumors. " 11/01/1998 - "These results show that B cell lymphomas can be 'foreignized' by MoAb-peptide P2 conjugates directed against the common B cell marker CD19 and eliminated by peptide P2-specific CD4+ T cells, via the ubiquitous Fas receptor. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Ligands
3.	Doxorubicin (Adriamycin)
4.	DNA (Deoxyribonucleic Acid)
5.	Peptides (Polypeptides)
6.	Small Interfering RNA (siRNA)
7.	Amifostine (Ethyol)
8.	Dihydrotachysterol (AT 10)
9.	Cyclodextrins
10.	Fas Ligand Protein (Fas Ligand)

Related Therapies and Procedures

1.	Immunotherapy
2.	Catheters
3.	Therapeutics
4.	Ligation
5.	Drug Therapy (Chemotherapy)