CD95 Antigens (fas Receptor)

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Also Known As:

Networked: 672 relevant articles (10 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kushlinskii, N E: 6 articles (11/2009 - 05/2000)
2.	Abbasova, S G: 6 articles (11/2009 - 05/2000)
3.	Lipkin, V M: 5 articles (08/2002 - 05/2000)
4.	Zacks, David N: 4 articles (05/2014 - 12/2004)
5.	Jaeschke, Hartmut: 4 articles (08/2013 - 10/2004)
6.	Fukuda, J: 4 articles (02/2004 - 07/2000)
7.	Haneji, T: 4 articles (02/2004 - 07/2000)
8.	Solary, Eric: 3 articles (01/2015 - 10/2003)
9.	Chinskey, Nicholas D: 3 articles (05/2014 - 04/2010)
10.	Liu, Kebin: 3 articles (06/2013 - 11/2010)

Related Diseases

1.	Neoplasms (Cancer) 06/04/1997 - "This study was conducted to further investigate the relationship between the modulation of Fas receptor gene and protein expression by treatment of cells with cytotoxic drugs and the immune clearance of tumor cells. " 10/01/2005 - "The aim of the study was to examine the concentrations of soluble Fas receptor (sFas) and the soluble ligand for the Fas receptor (sFasL) in serum of women with uterine tumors. " 09/01/2000 - "In vitro studies showed that the Fas receptor of thyroid tumor cells was functional, because apoptosis was induced by an agonistic Fas antibody. " 09/01/2015 - "Condurango (Gonolobus condurango) Extract Activates Fas Receptor and Depolarizes Mitochondrial Membrane Potential to Induce ROS-dependent Apoptosis in Cancer Cells in vitro: CE-treatment on HeLa: a ROS-dependent mechanism." 01/15/2015 - "Among the many immunomodulatory and anti-tumor activities, IFN-γ up-regulates tumor cell death mediated by Fas receptor (FasR). "
2.	Sepsis (Septicemia) 04/01/2000 - "Fas receptor-deficient mice had no protection against sepsis-induced apoptosis in thymocytes or splenocytes. " 05/01/2011 - "We propose to test the central hypothesis that RIP1 activation by death receptor (Fas) during sepsis determines whether the hepatocytes' fate is apoptotic versus necrotic. " 09/01/1996 - "Taken together, this study shows that measuring soluble Fas-receptor in myeloid leukemia is not diagnostically useful, but increased sCD95 may be associated with clinical complications like septicemias." 06/01/2004 - "The objective of the present study was to examine the levels of molecules associated with apoptosis belonging to the tumor necrosis factor (TNF)-alpha/TNF type-I receptor (TNFRI) and Fas ligand (FasL)/Fas receptor (Fas) pathways in patients with sepsis. " 10/01/2005 - "We therefore attempted to test the hypothesis that the hydrodynamic administration of small interfering RNA (siRNA) against the death receptor, Fas or caspase-8, should attenuate the onset of morbidity and mortality seen in sepsis, as produced by cecal ligation and puncture (CLP). "
3.	Inflammation 09/01/2013 - "This result was dependent on the presence of a normal Fas receptor and was not affected by inflammation induced by Fas activation. " 06/01/2006 - "In CHC cases, the histological activity index (HAI) revealed more expression of Fas antigen in liver tissues with active inflammation than in those without active inflammation (p < 0.01). " 01/01/2006 - "Inhibition of inflammation occurs with a significant rise in peripheral blood lymphocytes with receptor of activation apoptosis CD95 (Fas-antigen). " 10/01/1998 - "Histologically, soluble Fas antigen levels showed correlation with the levels of liver inflammation (p<0.01). " 12/01/1995 - "Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways."
4.	Hepatitis 06/01/1997 - "To evaluate the relationship between viral hepatitis and apoptosis, expression of Fas antigen in liver tissue sections of patients with viral hepatitis was investigated by immunohistochemical study using antibody to Fas antigen. " 09/01/2009 - "We report herein that MRL/Mp-Fas(lpr/lpr)-Sap(rpl/-) (MRL/lpr/rpl) mice lack Valpha14 NKT cells and are deficient in the Fas antigen but sensitive to Con A-induced hepatitis. " 10/01/2003 - "Apoptosis and its triggering molecule, Fas antigen, induce mechanisms that appear to be associated with the pathogenesis of chronic viral hepatitis." 10/01/2003 - "Apoptosis and Fas antigen expression in hepatocytes were correlated closely with histological activity (grade) of chronic viral hepatitis, but there were no correlations with histological stage, patient age or serum transaminase levels. " 10/01/2003 - "Fas antigen expression and apoptosis (apoptotic index) were assayed using flow cytometry in the hepatocytes of 27 patients with chronic viral hepatitis. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 11/01/1998 - "These results show that B cell lymphomas can be 'foreignized' by MoAb-peptide P2 conjugates directed against the common B cell marker CD19 and eliminated by peptide P2-specific CD4+ T cells, via the ubiquitous Fas receptor. " 01/01/2014 - "Recently, CTLA4-FasL, that can bind to B7 and Fas receptor (Fas), was shown to induce robust apoptosis of cell lines originating from B cell lymphomas expressing both B7 and Fas, by activating pro-apoptotic signals in parallel to abrogating anti-apoptotic ones. " 08/01/2003 - "The FAS antigen (CD95/APO-1) is suggested to be a tumor suppressor gene since mice and patients with congenital FAS mutations are prone to B cell lymphomas and somatic FAS mutations are described in hematological and solid tumors. " 01/01/2014 - "EGCG also inhibited the expression of the ligand of death receptor Fas (Fas-L), apoptosis regulator BAX (Bax) and tumor-suppressor protein p53, and increased the expression of B-cell lymphoma 2 (Bcl-2). " 04/15/1993 - "Coregulation of the APO-1 antigen with intercellular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas."

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Antigens
3.	Insulin (Novolin)
4.	Small Interfering RNA (siRNA)
5.	Amifostine (Ethyol)
6.	Fas Ligand Protein (Fas Ligand)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Proteins (Proteins, Gene)
9.	Caspase 3 (Caspase-3)
10.	CD95 Antigens (fas Receptor)

Related Therapies and Procedures

1.	Immunotherapy
2.	Catheters
3.	Ligation
4.	Drug Therapy (Chemotherapy)
5.	Photochemotherapy (Photodynamic Therapy)