CD29 Antigens

Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)

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Networked: 340 relevant articles (5 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bissell, Mina J: 6 articles (11/2013 - 10/2002)
2.	Park, Catherine C: 4 articles (07/2010 - 02/2006)
3.	Watt, Fiona M: 4 articles (02/2009 - 09/2004)
4.	Zha, Xiliang: 4 articles (10/2007 - 01/2004)
5.	Moro, Loredana: 4 articles (08/2006 - 12/2003)
6.	Marra, Ersilia: 4 articles (08/2006 - 12/2003)
7.	Qin, Jian: 4 articles (01/2005 - 10/2003)
8.	Dong, Cheng: 4 articles (11/2004 - 01/2003)
9.	Tang, Chih-Hsin: 3 articles (09/2010 - 12/2008)
10.	Fong, Yi-Chin: 3 articles (09/2010 - 12/2008)

Related Diseases

1.	Infection 07/01/2010 - "beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection." 03/01/2010 - "In the absence of beta1 integrin, endogenous Ag-specific CD4 T cells uniformly express high levels of alpha4beta7 after Listeria monocytogenes infection. " 01/01/2008 - "pseudotuberculosis infection activated Rho by a mechanism that was dependent on YopB and on high affinity bacteria interaction with beta1 integrin receptors. " 04/01/2002 - "A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. " 04/01/1997 - "pseudotuberculosis infection was specifically related to exposure of beta1 integrin (normally concealed by tight junctions) to the apical compartment, as Y. "
2.	Neoplasms (Cancer) 09/29/1998 - "Our study with a panel of cancer cell lines further showed a close correlation between alpha2 beta1 and alpha3 beta1 integrin receptor expression and the capability to attach to cortical bone. " 01/01/2015 - "Based on the knowledge mentioned above, we present hypotheses that we can inhibit specifically the expression of alpha5/beta1 integrin in cancer cells with the help of complementary replication defective adenovirus. " 07/28/2011 - "5'-NIO inhibited the beta1 Integrin/FAK/Akt pathway which can then facilitate invasion and/or migration of cancer cells through the extracellular matrix (ECM). " 02/01/2010 - "The expression of Integrin beta1 decreases when the differentiation level of tumor cells increase, indicating that integrin beta1 is closely related with the initiation of SCC and potential cancer stem cells in SCC." 02/01/2010 - "In SCC A431 cells, integrin beta1 was expressed unevenly in tumor cells. "
3.	Carcinoma (Carcinomatosis) 06/01/2008 - "We recently showed that the motility of the malignant Calu-1 human epidermoid lung carcinoma cells correlates to their expression levels of alpha2, alpha3, alpha6, and beta1 integrin subunits. " 08/03/2007 - "Effect of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells." 07/01/2007 - "Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes." 05/01/2006 - "The role of beta1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistance." 10/01/2005 - "However, when alpha9beta1 integrin is not expressed--as in many carcinoma cells--other members of the beta1 integrin family can replace its ligand binding activity. "
4.	Hemangioma (Angioma) 11/01/2008 - "Normalization of the constitutive VEGFR2 signaling in hemECs with soluble VEGFR1 or antibodies that neutralize VEGF or stimulate beta1 integrin suggests that local administration of these or similar agents may be effective in hemangioma treatment."
5.	Melanoma (Melanoma, Malignant) 04/25/2005 - "Flexible, actin-based ridges colocalise with the beta1 integrin on the surface of melanoma cells." 02/01/2004 - "The expression levels of beta1 integrin were also compared with those of Bcl-2, an anti-apoptotic protein, the presence of which is associated with treatment response and survival in melanoma. " 07/04/2003 - "The attachment of melanoma cells to LTBP-2 was prevented with monoclonal antibody against beta1 integrin in a concentration-dependent manner, suggesting an important role for beta1 integrin in the process. " 06/01/2000 - "On the basis of beta1 integrin expression, the melanoma samples were divided into two groups: beta1-negative tumours (<10% beta1 integrin immunostained cells) and beta1-positive tumours (with > or = 10% positive cells). " 06/01/2000 - "Prognostic value of beta1 integrin expression in metastatic melanoma."

Related Drugs and Biologics

1.	Fibronectins (Fibronectin)
2.	Integrins
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Integrin beta3 (GPIIIa)
5.	Antibodies
6.	Integrin alpha3
7.	Progesterone
8.	Calcium
9.	Laminin (Merosin)
10.	Collagen Type IV (Type IV Collagen)

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Tooth Movement
4.	Heterologous Transplantation (Xenotransplantation)
5.	Ligation