Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)

Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)

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Networked: 2515 relevant articles (56 outcomes, 292 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schalkwijk, Casper G: 9 articles (08/2015 - 06/2005)
2.	Libby, Peter: 9 articles (04/2015 - 09/2002)
3.	Stehouwer, Coen D A: 9 articles (03/2015 - 04/2002)
4.	Choudhury, Robin P: 8 articles (05/2013 - 10/2007)
5.	Panés, Julián: 8 articles (03/2006 - 04/2002)
6.	Yang, Chuen-Mao: 7 articles (08/2015 - 10/2007)
7.	McAteer, Martina A: 7 articles (06/2012 - 10/2007)
8.	Gironella, Meritxell: 7 articles (03/2006 - 05/2002)
9.	Piqué, Josep M: 7 articles (10/2005 - 04/2002)
10.	Molema, Grietje: 6 articles (12/2015 - 10/2005)

Related Diseases

1.	Inflammation 04/01/2009 - "In summary, targeted inactivation of EL attenuated allergic inflammation in the lung, and the protective effects in EL-KO mice were associated with high plasma HDL levels, downregulation of VCAM-1, and loss of the direct ligand-binding function of EL. " 06/01/2009 - "To study the expression and significance of vascular cell adhesion molecule-1 (VCAM-1) in subjects with allergic inflammation of respiratory tract. " 12/01/2015 - "Here, we describe the development of a novel aptamer-based near infrared fluorescence imaging probe targeting Vascular Cell Adhesion Molecule-1 (VCAM-1), an adhesion molecule overexpressed by the activated cerebrovasculature during inflammation. " 08/19/2015 - "Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates." 08/01/2015 - "Vascular cell adhesion molecule-1 (VCAM-1) is one kind of adhesion molecules participating in the process of polymorphonuclear leukocyte transmigration and regulating the occurrence and amplification of tissue inflammation. "
2.	Atherosclerosis 02/01/2000 - "In a second study, VCAM-1 expression in the aortic arch and the extent of atherosclerosis in the aortic origin were significantly greater in old LDLR-/- mice than in young LDLR-/- mice. " 01/01/2004 - "We speculate that this drug might be doubly effective in reducing atherosclerosis and cardiac events in these patients as a result of its demonstrated anti-oxidative effects and its ability to reduce VCAM-1 levels." 05/01/2015 - "This study demonstrates, in vitro, the regulatory mechanisms involved in MCP-1 production in three cellular models and VCAM-1 production in HUVECs, and thus mimics the endothelial dysfunction caused by AGEs in early atherosclerosis. " 10/01/1993 - "These studies suggest a molecular linkage between an antioxidant sensitive transcriptional regulatory mechanism and VCAM-1 gene expression that expands on the notion of oxidative stress as an important regulatory signal in the pathogenesis of atherosclerosis." 12/01/2015 - "Recruitment of foamy monocytes to inflamed endothelium expressing VCAM-1 contributes to the development of plaque during atherogenesis. "
3.	Neoplasms (Cancer) 05/01/2015 - "In this study, we investigated the MV-mediated transformation of normal fibroblasts to tumor-associated fibroblasts, focusing on the functional regulation of vascular cell adhesion molecule-1 (VCAM-1) expression. " 10/15/1998 - "In the present study, we extend this finding to a naturally occurring marker of tumor vascular endothelium, vascular cell adhesion molecule-1 (VCAM-1). " 06/01/2015 - "By illustrating the intriguing role of VCAM-1 in cancer disease, VCAM-1 is suggested as a new and up to now underestimated target in cancer treatment and in clinical diagnosis of malignancies. " 08/01/2014 - "The stage of disease and tumor histology were not correlated with serum VCAM-1 assay (p > 0.05). " 11/01/2013 - "VCAM-1 expression correlated with tumor stage. "
4.	Necrosis 03/01/2013 - "They were effective in attenuation of inflammatory nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling: decrease of tumour necrosis factor-alpha (TNF-α)-induced leukocytes adhesion, expression of adhesion molecules inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and nuclear translocation of NF-κB components as well as some revert of inhibitor of kappa B (IκB) ubiquitination. " 12/01/2014 - "As compared to controls, GD-HUVEC exhibited enhanced monocyte adhesion and vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1(ICAM-1) expression and exposure on plasma membrane after tumour necrosis factor-alpha(TNF-α) stimulation (Western blot, flow cytometer). " 09/01/2012 - "Hexanic LSESr inhibited tumour-necrosis-factor-α-induced MCP-1/CCL2 secretion by the human vascular endothelial cell line EAhy.926, as well as surface VCAM-1 protein expression, in a concentration-dependent manner. " 01/01/2012 - "By day 6, the monocyte-derived cells expressed vascular cell adhesion molecule 1 in response to tumour necrosis factor alpha. " 05/01/2011 - "Mb stimulated HO-1 (haem oxygenase-1), TNFα (tumour necrosis factor α), and both ICAM (intercellular adhesion molecule) and VCAM (vascular cell adhesion molecule) gene expression and inhibited epithelial monolayer permeability. "
5.	Infection 03/01/2008 - "We propose that the impaired migration of these accessory cells in the brain may explain the improved clinical outcome of infection in VCAM-1 mutant mice. " 05/01/2001 - "The present study shows that infection of EC with these three pathogens induces surface expression of intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) and monocyte adhesion. " 05/01/1995 - "This study reports on the endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) in the central nervous system (CNS) early after experimental infection of rhesus monkeys (Macaca mulatta) with pathogenic and nonpathogenic simian immunodeficiency virus (SIV). " 09/01/2015 - "PHZ administration during PbA infection significantly increased the expression of CXCL9 (P <0.05) and VCAM-1 (P <0.001) in the brain, increased the expression of CXCL10, CCL5 and CXCR3, and significantly increased the recruitment of CD4(+) and CD8(+) T cells (P <0.001 and P <0.01, respectively) as well as CD11b(+) Gr1(+) cells to the brain. " 06/01/2010 - "The present data show a small but statistically significant overexpression of VCAM-1 after astrocyte infection with TMEV that could play a significant role in vivo."

Related Drugs and Biologics

1.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2.	Interleukin-6 (Interleukin 6)
3.	E-Selectin
4.	P-Selectin
5.	C-Reactive Protein
6.	Integrin alpha4beta1 (VLA-4)
7.	NF-kappa B (NF-kB)
8.	Apolipoproteins E (ApoE)
9.	Apolipoproteins
10.	Antibodies

Related Therapies and Procedures

1.	Microbubbles
2.	Ligation
3.	Transplants (Transplant)
4.	Homologous Transplantation (Allograft)
5.	Renal Dialysis (Hemodialysis)