HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

P-Selectin

Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.

Also Known As:

CD62P Antigen; PADGEM; Antigen, CD62P; Platelet alpha Granule Membrane Protein; Selectin, P; Antigens, CD62P; CD62P Antigens; GMP-140; LECAM-3; P Selectin; Platelet alpha-Granule Membrane Protein

Networked: 2139 relevant articles (69 outcomes, 297 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lip, Gregory Y H: 32 articles (08/2014 - 05/2002)
2.	Blann, Andrew D: 24 articles (08/2015 - 05/2002)
3.	Blann, A D: 24 articles (01/2014 - 01/2000)
4.	Wakefield, Thomas W: 19 articles (04/2015 - 09/2002)
5.	Myers, Daniel D: 19 articles (04/2015 - 11/2002)
6.	Hawley, Angela E: 18 articles (04/2015 - 09/2002)
7.	Granger, D Neil: 17 articles (07/2011 - 12/2002)
8.	Henke, Peter K: 16 articles (04/2015 - 09/2002)
9.	Wrobleski, Shirley K: 15 articles (04/2015 - 11/2002)
10.	Schaub, Robert G: 14 articles (04/2015 - 07/2002)

Related Diseases

1.	Ischemia 05/01/1999 - "Animal survival was significantly improved after 75 minutes of total hepatic ischemia in P-selectin deficient mice when compared with wild-type mice. " 11/01/1995 - "Rolling in the postcapillary venules in SC tissue of P-selectin-deficient mice was significantly lower than that in wild-type mice under the basal conditions and post-ischemia-reperfusion (P < .05), but was not eliminated by the deletion of the P-selectin gene. " 11/15/2002 - "Placebo-blinded administration of the humanized anti-human E- and P-selectin monoclonal antibody (HuEP5C7, 20 mg/kg IV, n=9; placebo, n=9) immediately after the onset of 1 hour of temporary ischemia resulted in trends showing reduced polymorphonuclear leukocyte (PMN) infiltration into ischemic cortex, reduced infarct volumes (by 41%), improved neurological score (by 35%), and improved ability to self-care (by 39%). " 07/01/1999 - "P-selectin inhibition prevents early neutrophil activation but provides only modest protection against myocardial injury in dogs with ischemia and forty-eight hours reperfusion." 10/01/1995 - "Survival improved from 15 percent for the rats in the ischemia control group to 55 percent for those in the group receiving anti-P-selectin antibody given 30 minutes before reperfusion (p < 0.05). "
2.	Reperfusion Injury 01/01/2004 - "In addition, treatment with anti-P-selectin antibody to reduce the neutrophil-mediated reperfusion damage was equally effective in the absence of C3. " 09/01/1999 - "Is anti-P-selectin therapy effective in hepatic ischemia-reperfusion injury because it inhibits neutrophil recruitment?" 08/01/2010 - "Our study demonstrates that PCI induces temporal changes of P-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. " 01/01/2005 - "The purpose of this study was to define the kinetic changes in expression of P-selectin on myocardial vessels in a model of global ischemia-reperfusion injury. " 09/01/1999 - "In this study, we hypothesized that P-selectin on platelets may enhance neutrophil endothelial adherence and this may play a role in neutrophil-mediated reperfusion injury. "
3.	Inflammation 04/01/2015 - "Addition of P-selectin to models containing traditional PAD risk factors and markers of inflammation/coagulation significantly improved the net reclassification for ABI progression (p = 0.03), but was only marginally significant for incident PAD (p = 0.06). " 06/15/1996 - "The demonstration that P-selectin mediates eosinophil but not neutrophil influx suggests that suppressing the function of this adhesion molecule may be beneficial in blocking eosinophil accumulation in pleural inflammation." 08/01/2010 - "This study evaluated platelet P-selectin expression as a biomarker for cutaneous inflammation. " 02/01/2008 - "This study is the first to demonstrate a reduction in MPTFA associated with vein reopening and reduced vein inflammation due to oral P-selectin inhibition in a baboon model of DVT." 08/01/2007 - "Therefore, the aim of the present study was to investigate the differential influence of platelet and endothelial P-selectin on the extent of inflammation in AiA. "
4.	Thrombosis (Thrombus) 01/01/2015 - "This study shows that EPCs impair platelet aggregation and reduce thrombus formation via a cellular mechanism involving binding to platelet P-selectin. " 01/01/2015 - "In the present study, we assessed the impact of EPCs on thrombus formation and we addressed the implication of P-selectin in this process. " 01/01/2014 - "The aim of this study was to determine whether Gata1(low) mice would develop thrombosis with age and, in this case, the role played by P-selectin in the development of the trait. " 09/01/2011 - "This study demonstrates that the role of platelet P-selectin is not solely adhesive; its binding to PSGL-1 induces platelet activation that enhances platelet aggregation and thrombus formation. " 09/01/2011 - "This study supports (99m)Tc-fucoidan as a relevant imaging agent for in vivo detection of biologic activities associated with P-selectin overexpression, such as arterial thrombus and ischemic memory. "
5.	Atherosclerosis 09/17/2002 - "This mechanism represents an important component explaining the protection against neointimal growth in P-selectin-deficient mice and may represent a novel approach to the treatment of restenosis or atherosclerosis by the administration of chemokine receptor antagonists." 01/01/2009 - "Our results indicate that, compared with controls, selective disruption of E- and P-selectin ligand synthesis resulted in a significant reduction in atherosclerosis. " 05/01/2015 - "P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA)." 06/01/2009 - "We therefore investigated the association of SELP polymorphisms with platelet SELP measures and polymorphisms in the SELPLG gene (selectin P ligand) with lymphocyte, granulocyte, and monocyte SELPLG measures among 1870 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. " 03/30/2001 - "In vitro studies show that inflammatory factors, such as P-selectin and MCP-1, which can be upregulated by Ang-II, play an important role in atherogenesis. "

Related Drugs and Biologics

1.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
2.	L-Selectin
3.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
4.	von Willebrand Factor
5.	Glycoproteins (Glycoprotein)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	CD40 Ligand (CD40L)
8.	5- acetylneuraminyl- (2- 3)- galactosyl- (1- 4)- (fucopyranosyl- (1- 3))- N- acetylglucosamine (sialyl Lewis x)
9.	Thrombin
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Microbubbles
2.	Thrombolytic Therapy
3.	Transplantation (Transplant Recipients)
4.	Intravenous Injections
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)